Composite azelaic acid emulsion for preventing allergy and removing acnes and preparation method thereof

A technology of azelaic acid, sensitization and anti-acne, applied in the field of azelaic acid emulsion and its preparation, can solve the problems of patients' heavy mental burden, achieve the effect of relieving blackheads, closed mouth and acne marks, fine pores, and balance oil

Pending Publication Date: 2021-11-09
JIANGSU SEMPOLL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the disease is generally not harmful to the overall health of the patient, it often brings a heavy mental burden to the pati

Method used

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  • Composite azelaic acid emulsion for preventing allergy and removing acnes and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] To prepare 1000g of emulsion, the following materials are used:

[0036] .

[0037] Such as figure 1 ,Preparation Process:

[0038] (1) Put 551.45g of water, 1g of disodium EDTA, 10g of steareth-21, 5g of steareth-2, and 1g of benzoic acid into the emulsification pot, heat to 70-75°C, and stir for 20-30 rpm / min, stirring for 5-10 minutes, homogenizing at 2200-2500 rpm, homogenizing for 5-10 minutes, until evenly dispersed.

[0039] (2) Keep warm at 70-75°C, add 60g of butanediol, 40g of glycerin, 10g of propylene glycol, 40g of polydimethylsiloxane, 10g of caprylic acid / capric triglyceride, 5g of hydrogenated lecithin, and 5g of wild soybean sterols Emulsification pot, homogenize at 2200-2500 rpm, homogenize for 5-10 minutes, stir at 20-30 rpm, stir for 5-10 minutes, until the emulsification is uniform.

[0040](3) Cool down to 60-65°C, add carbomer 4g into the emulsification pot, stir at 20-30 rpm, stir for 5-10 minutes, homogenize at 2200-2500 rpm, homogenize ...

Embodiment 2

[0045] To prepare 1000g of emulsion, the following materials are used:

[0046] .

[0047] Preparation Process:

[0048] (1) Put 634.49g of water, 3g of disodium EDTA, 5g of steareth-21, 1g of steareth-2, and 1g of benzoic acid into the emulsification pot, heat to 70-75°C, and stir for 20-30 rpm / min, stirring for 5-10 minutes, homogenizing at 2200-2500 rpm, homogenizing for 5-10 minutes, until evenly dispersed.

[0049] (2) Keep warm at 70-75°C, add 80g of butanediol, 30g of glycerin, 10g of propylene glycol, 50g of polydimethylsiloxane, 10g of caprylic acid / capric triglyceride, 1g of hydrogenated lecithin, and 1g of wild soybean sterols Emulsification pot, homogenize at 2200-2500 rpm, homogenize for 5-10 minutes, stir at 20-30 rpm, stir for 5-10 minutes, until the emulsification is uniform.

[0050] (3) Cool down to 60-65°C, add carbomer 4g into the emulsification pot, stir at 20-30 rpm, stir for 5-10 minutes, homogenize at 2200-2500 rpm, homogenize for 5-10 minutes, u...

Embodiment 3

[0055] To prepare 1000g of emulsion, the following materials are used:

[0056] .

[0057] Preparation Process:

[0058] (1) Put 612.93g of water, 1g of disodium EDTA, 10g of steareth-21, 10g of steareth-2, and 3g of benzoic acid into the emulsification pot, heat to 70-75°C, and stir for 20-30 rpm / min, stirring for 5-10 minutes, homogenizing at 2200-2500 rpm, homogenizing for 5-10 minutes, until evenly dispersed.

[0059] (2) Keep warm at 70-75°C, add 30g of butanediol, 20g of glycerin, 5g of propylene glycol, 10g of polydimethylsiloxane, 5g of caprylic acid / capric triglyceride, 10g of hydrogenated lecithin, and 10g of wild soybean sterols Emulsification pot, homogenize at 2200-2500 rpm, homogenize for 5-10 minutes, stir at 20-30 rpm, stir for 5-10 minutes, until the emulsification is uniform.

[0060] (3) Cool down to 60-65°C, add carbomer 1g into the emulsification pot, stir at 20-30 rpm, stir for 5-10 minutes, homogenize at 2200-2500 rpm, homogenize for 5-10 minutes,...

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Abstract

The invention discloses a composite azelaic acid emulsion for preventing allergy and removing acnes and a preparation method thereof. The functional component is prepared from the following raw materials in parts by mass: 10-20 parts of azelaic acid, 0.5-2 parts of salicylic acid, 0.1-1 part of tranexamic acid, 0.1-1 part of bisabolol, 0.1-1 part of hamamelis virginiana water, 0.1-1 part of herba portulacae extract and 0.1-1 part of wild soybean sterol. The composite azelaic acid emulsion can well penetrate through the surface layer of the skin to be absorbed, all the components are matched according to a specific proportion, and the composite azelaic acid emulsion is rich in various functional components which cooperate with one another, can achieve the effects of softening cutin, refining pores, inhibiting bacteria, diminishing inflammation, resisting irritation, balancing grease and relieving blackheads, closed mouths and acne marks, and has the excellent effects of preventing allergy, relieving, removing acnes and protecting the skin.

Description

technical field [0001] The invention relates to an azelaic acid emulsion and a preparation method thereof, in particular to a compound azelaic acid emulsion for preventing allergy and removing acne and a preparation method thereof. Background technique [0002] "Acne" is a common name for acne, also known as "acne", "acne" or "acne". It is a skin disease caused by blockage and inflammation of hair follicles and sebaceous glands. Although the disease is generally not harmful to the overall health of the patient, it often brings a heavy mental burden to the patient because it is prone to occur in the face and other parts, and if it is not treated in time, it will leave scars that damage the appearance. [0003] Azelaic acid, also known as rhododendronic acid, is a complex molecule with multiple activities. With the continuous understanding of its clinical application, the anti-inflammatory, anti-infection and antibacterial effects of azelaic acid have been discovered and confi...

Claims

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Application Information

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IPC IPC(8): A61K8/9789A61K8/63A61K8/34A61K8/44A61K8/368A61K8/362A61Q19/00A61Q17/00A61P17/10A61P37/08A61P17/02A61P29/00
CPCA61K8/9789A61K8/63A61K8/342A61K8/44A61K8/368A61K8/362A61Q19/00A61Q17/005A61P17/10A61P37/08A61P17/02A61P29/00A61K2800/592A61K2800/5922A61K2800/78
Inventor 鲍丰祺顾敏蔡蓓蕾
Owner JIANGSU SEMPOLL PHARMA
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