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Continuous production method of benzoic acid derivative

A production method and derivative technology, applied in the direction of organic chemical methods, chemical instruments and methods, preparation of organic compounds, etc., can solve problems such as pipeline blockage, stirring paddle break safety accidents, etc., to promote the reaction, increase the degree of turbulence, Increase the effect of gas-liquid mass transfer

Active Publication Date: 2021-11-12
浙江优创材料科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Safety accidents caused by pipeline blockage and stirring paddle breakage during the oxidation reaction occur from time to time

Method used

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  • Continuous production method of benzoic acid derivative
  • Continuous production method of benzoic acid derivative
  • Continuous production method of benzoic acid derivative

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] About the device

[0029]The continuous reaction device comprises successively connected head tanks 3 (the head tanks 3 connect toluene derivative storage tanks 1 and nitric acid storage tanks 2), a circular reactor 6, a crystallization kettle 5 and a centrifuge 4; the crystallization kettle 5 is two , when the liquid holding capacity of one of the crystallization tanks 5 exceeds 70%, the material flowing out from the return-shaped reactor 6 is diverted to another crystallization tank 5 . The circular reactor 6 comprises a small-diameter casing 62, the small-diameter casing 62 is covered with a large-diameter casing 61 (coaxially sleeved together), and a circular cavity is formed between the small-diameter casing 62 and the large-diameter casing 61 , be provided with small pipeline 63 in the back-shaped cavity, be provided with some apertures on the small pipeline 63, be oxygen in the small pipeline, small-diameter sleeve pipe 61 rotates, large-diameter sleeve pipe 62 i...

Embodiment 2-12

[0033] Embodiment 2-12 The reaction parameters are shown in the table below, the device is the same, and other operations are the same as in the examples.

[0034]

[0035]

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Abstract

The invention relates to the field of benzoic acid derivative preparation processes, in particular to a continuous production method of a benzoic acid derivative. The invention relates to a continuous production method of a benzoic acid derivative, the method is characterized in that the benzoic acid derivative is prepared in a continuous reaction device with a concentric-square-shaped reactor in the presence of nitric acid by taking an oxygen-containing gas as an oxidizing agent and taking a toluene derivative as a raw material, and the concentric-square-shaped reactor comprises a small-diameter sleeve, the small-diameter sleeve is sleeved with a large-diameter sleeve, a hollow-square-shaped cavity is formed between the small-diameter sleeve and the large-diameter sleeve, a small pipeline is arranged in the hollow-square-shaped cavity, a plurality of small holes are formed in the small pipeline, oxygen is contained in the small pipeline, the small-diameter sleeve rotates, the large-diameter sleeve is fixed, the reaction liquid composed of nitric acid and toluene derivatives is arranged between the small-diameter sleeve and the large-diameter sleeve.

Description

technical field [0001] The invention relates to the field of preparation technology of benzoic acid derivatives, in particular to a continuous production method of benzoic acid derivatives. Background technique [0002] Benzoic acid derivatives are an important class of fine chemical intermediates with high application value and biological activity. They are widely used in the fields of medicine, food, dyes, etc., and can be used to prepare drugs, fungicides, insecticides, and herbicides. , preservatives, plasticizers, spices and mordants, etc. For example: tetrafluorobenzoic acid is widely used in the preparation of quinolones, which have a bactericidal effect on a variety of Gram-negative bacteria, and are mainly used in diseases of the genitourinary system, gastrointestinal diseases, and leather such as respiratory tract and skin tissue. Treatment of blue-negative bacterial infections. In medicine, 3,4,5-trimethoxybenzoic acid is an important intermediate of gastric med...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C51/265C07C201/12C07C303/22B01J19/18B01J19/00C07C205/57C07C65/21C07C309/58C07C63/04C07C63/70C07C63/26C07B41/08
CPCC07C201/12C07C303/22C07C51/265B01J19/1843B01J19/0053B01J19/0013B01J19/0006C07B41/08B01J2219/00081B01J2219/00094C07C205/57C07C65/21C07C309/58C07C63/04C07C63/70C07C63/26
Inventor 吴建龙冯秋生马才英贾建洪
Owner 浙江优创材料科技股份有限公司
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