Bonded phase chromatographic analysis method for tocopheryl acetate in electronic cigarette oil

A technology of tocopherol acetate and electronic cigarette oil is applied in the field of convergence chromatography analysis of tocopherol acetate, which can solve the problems of large consumption of organic solvents and long analysis time, and achieve the effect of rapid determination

Pending Publication Date: 2021-11-12
SHENZHEN BOTON FLAVORS & FRAGRANCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The gas chromatography analysis method often takes a long time to analyze, the analysis time is more than 30min, and the normal phase liquid chrom

Method used

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  • Bonded phase chromatographic analysis method for tocopheryl acetate in electronic cigarette oil
  • Bonded phase chromatographic analysis method for tocopheryl acetate in electronic cigarette oil
  • Bonded phase chromatographic analysis method for tocopheryl acetate in electronic cigarette oil

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0029] Example 1

[0030] (1) Preparation of electronic butter sample

[0031] 0.1 g Electronic butter oil is weighed into a 10 mL volumetric flask with isopropanol solvent, and then filtered with 0.22 μm filtration membranes;

[0032] (2) Standard working solution

[0033] Weigh 52.0 mg of totropher acetate standard, to be used to obtain a mother liquor in a 50 mL capacity bottle with isopropanol solvent; In the bottle; standard working fluid having a standard series solution of 1 to 500 μg / ml; such as a standard working solution having a concentration of 1.0 μg / ml, 10.0 μg / ml, 20.0 μg / mL, 100.0 μg / mL, 500.0 μg / ml. ;

[0034] (3) Complex chromatography analysis

[0035] The standard working solution obtained by the step (2) and the electronic butter sample obtained by the step (1) obtained by an ultra-efficient syringe chromatograph were used to detect by a diode array detector (PDA).

[0036] For the choice of the column, three control groups are provided, which use ...

Example Embodiment

[0037] Example 2

[0038] (1) Preparation of electronic butter sample

[0039] It is called 0.2 g of electronic butter oil, and is polyhydropane: isopropyl alcohol (8: 2, v / v) solvent to 10 ml of volumetric flask, and then filtered with 0.22 μm nylon filtration membranes.

[0040] (2) Standard working solution

[0041] It is called 52.0 mg of totropher acetate standard, and nanophenic acid (8: 2, v / v) solvent is disposed to 50 ml of capacity bottle to obtain mother liquor; each takes 10, 100, 200, 1000, respectively. 5000 μL of mother liquor, then use n-heptane: isopropyl alcohol (8: 2, v / v) solvent to be contained in a 10 mL volumetric flask;

[0042] (3) Complex chromatography analysis

[0043] The standard working solution obtained by the step (2) and the electronic butter sample obtained by the step (1) obtained by an ultra-efficient syringe chromatograph were used to detect by a diode array detector (PDA).

[0044] The Viridis HSS C18 Sb (2.1mm × 150mm, 1.8 μm) is used; t...

Example Embodiment

[0045] Example 3

[0046] (1) Preparation of electronic butter sample

[0047] It is weighed 0.5 g of electronic butter oil, with n-hexane: isopropyl alcohol (8: 2, v / v) solvent to 10 ml of volumetric flask, and then filtered with 0.22 μm filtration membranes;

[0048] (2) Standard working solution

[0049] Weigh 52.0 mg of totrocinol acetate standard, use n-hexane: isopropyl alcohol (8: 2, v / v) solvent to obtain mother liquor in 50 ml of volumetric flask; 10, 100, 200, 1000, 5000 μl, respectively Mother liquor, then use n-hexane: isopropyl alcohol (8: 2, v / v) to 10 mL volumetric flask;

[0050] (3) Complex chromatography analysis

[0051] The standard working solution obtained by the step (2) and the electronic butter sample obtained by the step (1) obtained by an ultra-efficient syringe chromatograph were used to detect by a diode array detector (PDA).

[0052] Viridis HSS C18 Sb (2.1mm × 150mm, 1.8 μm); the color column temperature is 40 ° C, the amount of injection is 1 ...

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Abstract

The bonded phase chromatographic analysis method for the tocopheryl acetate in the electronic cigarette liquid, provided by the invention, is used for determining the tocopheryl acetate in the electronic cigarette liquid; as tocopheryl acetate exists in the electronic cigarette oil and may cause harm to human health, whether tocopheryl acetate exists in the electronic cigarette oil or not needs to be rapidly detected in the production and inspection links of the electronic cigarette oil so as to realize quality control of the electronic cigarette oil; compared with reported gas chromatography and liquid chromatography methods, the method has the advantages that bonded phase chromatography analysis is adopted, so that the time is shorter; the optimized chromatographic conditions are as follows: an HSS C18 SB chromatographic column is adopted, 3% methanol and 97% CO2 are adopted as an elution solvent, the flow rate is 0.8 mL/min, and the back pressure is 2000 psi; a photodiode array (PDA) detector is selected in an experiment, the detection time is within 2 minutes when analysis is carried out under the wavelength of 220 nm, 97% of a mobile phase is CO2 and is safe and pollution-free to the environment, and the method is rapid and sensitive and provides a method basis for safety detection of the electronic cigarette.

Description

technical field [0001] The invention relates to the technical field of electronic cigarette oil chemical analysis, in particular to a convergence chromatography analysis method for tocopheryl acetate in electronic cigarette oil. Background technique [0002] Recently, the number of deaths from severe pneumonia caused by e-cigarette smoking in the United States has gradually increased, triggering widespread concerns about the safety of e-cigarettes. The survey of the Centers for Disease Control and Prevention (CDC) in the United States showed that tocopheryl acetate was detected in e-liquids smoked by multiple patients; Quality control is critical. Conventional analysis methods for tocopheryl acetate include gas chromatography, gas chromatography-mass spectrometry, normal phase liquid chromatography, and the like. [0003] The gas chromatography analysis method often takes a long time, the analysis time is more than 30 minutes, and the normal phase liquid chromatography ana...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/06G01N30/34
CPCG01N30/02G01N30/06G01N30/34G01N2030/047G01N30/00
Inventor 袁涛蔡佳桐徐潇李剑政
Owner SHENZHEN BOTON FLAVORS & FRAGRANCES
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