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Bonded phase chromatographic analysis method for tocopheryl acetate in electronic cigarette oil

A technology of tocopherol acetate and electronic cigarette oil is applied in the field of convergence chromatography analysis of tocopherol acetate, which can solve the problems of large consumption of organic solvents and long analysis time, and achieve the effect of rapid determination

Pending Publication Date: 2021-11-12
SHENZHEN BOTON FLAVORS & FRAGRANCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The gas chromatography analysis method often takes a long time to analyze, the analysis time is more than 30min, and the normal phase liquid chromatography analysis time also needs at least 10min, and the normal phase liquid chromatography analysis needs to consume a large amount of organic solvents

Method used

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  • Bonded phase chromatographic analysis method for tocopheryl acetate in electronic cigarette oil
  • Bonded phase chromatographic analysis method for tocopheryl acetate in electronic cigarette oil
  • Bonded phase chromatographic analysis method for tocopheryl acetate in electronic cigarette oil

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] (1) E-liquid sample preparation

[0031] Weigh 0.1g of e-liquid, dilute it to a 10mL volumetric flask with isopropanol solvent, and then filter it with a 0.22μm filter membrane to obtain a sample of e-liquid;

[0032] (2) Preparation of standard working solution

[0033] Weigh 52.0mg of tocopherol acetate standard substance, dilute to 50mL volumetric flask with isopropanol to obtain mother liquor; take 10, 100, 200, 1000, 5000μL of mother liquor respectively, and then dilute to 10mL volume with isopropanol In the bottle; obtain the standard working solution with a standard series solution concentration of 1-500 μg / mL; for example, the standard working solution with a concentration of 1.0 μg / mL, 10.0 μg / mL, 20.0 μg / mL, 100.0 μg / mL, and 500.0 μg / mL ;

[0034] (3) Convergence chromatography analysis

[0035] Concentration analysis of the standard working solution obtained in step (2) and the e-liquid sample obtained in step (1) is carried out by using an ultra-high perf...

Embodiment 2

[0038] (1) E-liquid sample preparation

[0039] Weigh 0.2g of e-liquid, use n-heptane:isopropanol (8:2, V / V) solvent to make up the volume into a 10mL volumetric flask, and then filter with a 0.22μm nylon filter membrane to obtain an e-liquid sample;

[0040] (2) Preparation of standard working solution

[0041] Take by weighing 52.0mg tocopherol acetate standard substance, use n-heptane: isopropanol (8:2, V / V) solvent to settle to obtain mother liquor in 50mL volumetric flask; Take 10, 100, 200, 1000, 5000 μL of mother liquor, and then use n-heptane:isopropanol (8:2, V / V) solvent to make up to 10mL volumetric flask;

[0042] (3) Convergence chromatography analysis

[0043] Concentration analysis of the standard working solution obtained in step (2) and the e-liquid sample obtained in step (1) is carried out by using an ultra-high performance convergence chromatograph, and detection is performed by a diode array detector (PDA);

[0044] Viridis HSS C18 SB (2.1mm×150mm, 1.8μm)...

Embodiment 3

[0046] (1) E-liquid sample preparation

[0047] Weigh 0.5g of e-liquid, use n-hexane:isopropanol (8:2, V / V) solvent to set the volume to a 10mL volumetric flask, and then filter with a 0.22μm filter membrane to obtain an e-liquid sample;

[0048] (2) Preparation of standard working solution

[0049] Weigh 52.0mg of tocopherol acetate standard substance, and use n-hexane:isopropanol (8:2, V / V) solvent to set the volume to a 50mL volumetric flask to obtain mother liquor; take 10, 100, 200, 1000, 5000 μL respectively Mother liquor, then use normal hexane: isopropanol (8:2, V / V) to be settled in the volumetric flask of 10mL;

[0050] (3) Convergence chromatography analysis

[0051] Concentration analysis of the standard working solution obtained in step (2) and the e-liquid sample obtained in step (1) is carried out by using an ultra-high performance convergence chromatograph, and detection is performed by a diode array detector (PDA);

[0052] Viridis HSS C18 SB (2.1mm×150mm, ...

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Abstract

The bonded phase chromatographic analysis method for the tocopheryl acetate in the electronic cigarette liquid, provided by the invention, is used for determining the tocopheryl acetate in the electronic cigarette liquid; as tocopheryl acetate exists in the electronic cigarette oil and may cause harm to human health, whether tocopheryl acetate exists in the electronic cigarette oil or not needs to be rapidly detected in the production and inspection links of the electronic cigarette oil so as to realize quality control of the electronic cigarette oil; compared with reported gas chromatography and liquid chromatography methods, the method has the advantages that bonded phase chromatography analysis is adopted, so that the time is shorter; the optimized chromatographic conditions are as follows: an HSS C18 SB chromatographic column is adopted, 3% methanol and 97% CO2 are adopted as an elution solvent, the flow rate is 0.8 mL / min, and the back pressure is 2000 psi; a photodiode array (PDA) detector is selected in an experiment, the detection time is within 2 minutes when analysis is carried out under the wavelength of 220 nm, 97% of a mobile phase is CO2 and is safe and pollution-free to the environment, and the method is rapid and sensitive and provides a method basis for safety detection of the electronic cigarette.

Description

technical field [0001] The invention relates to the technical field of electronic cigarette oil chemical analysis, in particular to a convergence chromatography analysis method for tocopheryl acetate in electronic cigarette oil. Background technique [0002] Recently, the number of deaths from severe pneumonia caused by e-cigarette smoking in the United States has gradually increased, triggering widespread concerns about the safety of e-cigarettes. The survey of the Centers for Disease Control and Prevention (CDC) in the United States showed that tocopheryl acetate was detected in e-liquids smoked by multiple patients; Quality control is critical. Conventional analysis methods for tocopheryl acetate include gas chromatography, gas chromatography-mass spectrometry, normal phase liquid chromatography, and the like. [0003] The gas chromatography analysis method often takes a long time, the analysis time is more than 30 minutes, and the normal phase liquid chromatography ana...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/06G01N30/34
CPCG01N30/02G01N30/06G01N30/34G01N2030/047G01N30/00
Inventor 袁涛蔡佳桐徐潇李剑政
Owner SHENZHEN BOTON FLAVORS & FRAGRANCES
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