Application of caffeol or caffeol derivative in preparation of anti-candida albicans drugs or anti-candida albicans daily necessities

Abstract

The invention discloses application of caffeol or a caffeol derivative in preparation of anti-candida albicans drugs or anti-candida albicans daily necessities. Candida albicans is taken as a test object, a compound which is efficient, low in toxicity and not prone to generating drug resistance is screened, and it is found that the caffeol or the caffeol derivative has a good inhibition effect on adhesion, hypha formation, biofilm formation and pathogenicity of the Candida albicans. The bean alcohol has a good inhibition effect on mouse oral cavity infection of a candida albicans strain SC5314, and the compound is non-toxic to human cells; the low-concentration kahweol and the low-concentration cafestol have no inhibition effect on cell growth of the candida albicans, which indicates that the effect of the caffeol or the caffeol derivative on the candida albicans does not depend on killing candida albicans cells, but inhibits the expression of pathogenic factors of the candida albicans, so that the caffeol or the caffeol derivative is not easy to generate drug resistance. The caffeol or the caffeol derivative has a good application prospect in the development of novel antifungal drugs, especially in the development of anti-candida albicans drugs.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and particularly relates to the application of cafestol or derivatives thereof in preparing anti-candida medicaments or anti-candida daily necessities. Background technique [0002] Candida albicans (Candida albicans) is a fungal disease widely spread in humans. It is an important opportunistic pathogenic fungus, usually causing acute, subacute or chronic infections, and it is also one of the most important pathogens of hospital-acquired infections. . On healthy human mucosal surfaces, such as the oral cavity and intestinal tract, Candida albicans usually does not cause disease, but in patients with compromised or suppressed immune systems, such as chemotherapy patients, organ transplant patients or AIDS patients, it can cause serious systemic damage. Sexual infection, the fatality rate is as high as 40%. [0003] At present, there are limited types of antifungal drugs clinically, among whi...

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Problems solved by technology

[0003] At present, there are limited types of antifungal drugs in clinical practice, among which azole drugs (fluconazole) are widely used, and fluconazole acts as a bacteriostasis by inhibiting fungal replication effect, but with the abuse of antibiotics, the phenomenon of drug resistance is becoming more and more serious

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