Inverse opal hydrogel microcarrier for treating wounds and application of inverse opal hydrogel microcarrier

An inverse opal and microcarrier technology, applied in the field of biomedical materials, can solve the problems of poor water-solubility and poor water-solubility of retinoic acid, and achieve the effect of good scar removal, convenient use and improvement of wound scars.

Pending Publication Date: 2021-12-03
温州瑞司特生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the poor water solubility of tretinoin, it usually needs to be administered in the form of cream
Therefore, how to overcome the shortcomin

Method used

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  • Inverse opal hydrogel microcarrier for treating wounds and application of inverse opal hydrogel microcarrier
  • Inverse opal hydrogel microcarrier for treating wounds and application of inverse opal hydrogel microcarrier
  • Inverse opal hydrogel microcarrier for treating wounds and application of inverse opal hydrogel microcarrier

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Embodiment 1

[0029] Embodiment 1: the preparation of inverse opal hydrogel microcarrier

[0030] An inverse opal hydrogel microcarrier, the preparation steps are as follows:

[0031] (1) Preparation of silica colloidal crystal template:

[0032] Select silicon dioxide particles with an average diameter of 200 nm, suspend them in absolute ethanol, vortex and ultrasonically disperse them in absolute ethanol, and prepare a silicon dioxide dispersion with a concentration of 2%. Insert the glass sheet vertically into the silica dispersion, and place it in a constant temperature and humidity box, and adjust the temperature in the box to 30 degrees Celsius and the humidity to 40%. With the evaporation of absolute ethanol, the silica particles are neatly arranged on the surface of the glass sheet, forming a silica colloidal crystal template.

[0033] (2) Preparation of inverse opal film microcarriers

[0034] First, the recipe for the inverse opal film is as follows:

[0035] Cyclodextrin 2g ...

Embodiment 2

[0047] Embodiment 2: Wound scar repair experiment

[0048] Methods: 18 large-eared white rabbits were purchased, male or female, with a body weight of 1.8-2.2kg. After adaptive feeding for 7 days, each white rabbit was observed, fed and watered, and there was no obvious abnormality, and they were included in the experiment. Establishment of scar animal model: anesthetized by injecting pentobarbital solution with a concentration of 30 g / L into the ear margin vein, and making a circular wound with a diameter of 1 cm on the ventral side of the rabbit ear along the long axis, two places in each ear, with an interval of about 3.0 cm, The full-thickness skin was completely removed, and the wound healed naturally after 21 days of skin transformation to form a hypertrophic scar mass. There was no unhealed wound infection or poor healing, and no new scar tissue was formed.

[0049] Grouping: 18 rabbits were randomly divided into 3 groups, namely blank group, experimental group and con...

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Abstract

The invention relates to an inverse opal hydrogel microcarrier for treating wounds. The inverse opal hydrogel microcarrier comprises 3.6-4.5 wt% of cyclodextrin, 3-5 wt% of polyacrylic acid and 3-5 wt% of agar, the inverse opal hydrogel microcarrier has pores with an average particle size of 100-300 nm, and tretinoin is loaded in the pores. The inverse opal hydrogel microcarrier can load tretinoin, is helpful for the tretinoin to improve wound scars, and has the advantages of convenience in use and good scar removal effect.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to an inverse opal hydrogel microcarrier for treating wounds. Background technique [0002] Over the years, the first aid treatment for sudden accidents in daily life, the doctor’s wound hemostasis during the operation of the patient, and the rescue and hemostasis of the wounded soldiers in the war are mostly through physical oppression, such as bandages, gauze, rubber strips, etc., but The effect is limited. In clinical medicine, the demand for bandaging and hemostasis in the whole chain of the rescue ladder, especially for acute severe bleeding of wounds in emergencies, due to the variety of wet states and dynamic complexity of the sudden bleeding environment, currently available hemostatic products cannot meet the requirements. Rapid and effective hemostasis can also have an antibacterial effect, and hemorrhagic shock is very prone to life-threatening. At present, the hemost...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K47/40A61K47/32A61K47/36A61K47/04A61K31/203A61P17/02A61L15/28A61L15/24A61L15/18A61L15/20A61L15/44
CPCA61K9/7007A61K47/40A61K47/32A61K47/36A61K47/02A61K31/203A61P17/02A61L15/28A61L15/24A61L15/18A61L15/20A61L15/44A61L2300/412A61L2300/428C08L5/16C08L5/12C08L33/02
Inventor 肖健张宏宇李春波许可
Owner 温州瑞司特生物科技有限公司
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