Nano photo-thermal material for laser hair removal and preparation method thereof

A nano-light and thermal material technology, applied in the field of hair removal, can solve problems such as skin sensitivity, heat or itching, redness and swelling of the hair removal site, reduce the frequency of laser hair removal, improve the effect of hair removal, and promote the effect of necrosis.

Active Publication Date: 2021-12-03
THE FIRST PEOPLES HOSPITAL OF FOSHAN +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Moreover, the process of laser hair removal will produce more obvious pain, and the hair removal site may produce slight redness, skin sensitivity, heat or itching and other side effects. Many people cannot tolerate multiple laser hair removal treatments.

Method used

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  • Nano photo-thermal material for laser hair removal and preparation method thereof
  • Nano photo-thermal material for laser hair removal and preparation method thereof
  • Nano photo-thermal material for laser hair removal and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0036] A kind of nano photothermal material, its preparation raw material comprises indocyanine green, polylactic acid-glycolic acid copolymer, methanol solution, acetonitrile solution and PVA aqueous solution, wherein polylactic acid-glycolic acid copolymer wraps indocyanine green to form nanoparticle, The particle size of the nanoparticles is 220-300nm, and the mass ratio of indocyanine green to PLGA is 1.67:1.

[0037] A method for preparing a nano-photothermal material, comprising the steps of:

[0038] Add 10 mg of indocyanine green into 1 mL of methanol solution, and perform ultrasonic mixing and dissolving to obtain an indocyanine green solution;

[0039] Add 6mg PLGA into 3mL acetonitrile solution, and carry out ultrasonic mixing and dissolving to obtain PLGA solution;

[0040] Mix the indocyanine green solution and the PLGA solution, and add 5 mL of 5% PVA aqueous solution under magnetic stirring, and vortex for 30 seconds to obtain a uniform emulsion;

[0041] Stir...

Embodiment 2

[0044] The application experiment of the nanometer photothermal material that embodiment 1 makes in laser hair removal, the working principle of laser hair removal is as follows figure 1As shown, the specific steps are as follows:

[0045] After 8-week-old C57 mice were anesthetized with 0.1% pentobarbital sodium intraperitoneally, the hair on the back of the C57 mice was removed with Veet hair removal cream, and then the skin on the back of the mice was wiped clean with clean water, divided into upper back And the lower back, take a 3mm circle each on the upper back and lower back, as the treatment part, mark it with a marker pen;

[0046] Use a wet cotton swab to dip 40 μL of indocyanine green-PLGA nano-photothermal material and smear it on the treated part of the upper back of the mouse as the experimental site; the treated part of the lower back of the mouse is not treated as the control site. Such as image 3 As shown, the dotted box A is the experimental site, and the ...

Embodiment 3

[0050] The difference between Example 3 and Example 1 is that the mass ratio of indocyanine green to PLGA in Example 3 is 1:1, and the application experiment of nano-photothermal materials in laser hair removal is the same as that of Example 2.

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Abstract

The invention belongs to the technical field of unhairing, and particularly discloses a nano photo-thermal material for laser hair removal and a preparation method thereof. The nano photo-thermal material comprises photo-thermal dye and a carrier, and the carrier wraps the photo-thermal dye to form nanoparticles; and the particle size of the nanoparticles is 50-300 nm. The preparation method of the nano photo-thermal material comprises the following step that the photo-thermal dye and the carrier are mixed to prepare the nano photo-thermal material. According to the nano photo-thermal material for laser hair removal and the preparation method thereof, hair shedding is promoted based on the nano photo-thermal material, the nano photo-thermal material with a photo-thermal effect is locally smeared, due to the fact that the nano photo-thermal material is small in particle size, the nano photo-thermal material is easily enriched on a hair follicle portion after being smeared on a skin portion, the nano photo-thermal material generates the photo-thermal effect by absorbing light energy of laser, the light energy is rapidly converted into heat energy. Hair follicles are necrotized by means of the heat energy, so that the purpose that hair does not grow any more is achieved.

Description

technical field [0001] The invention belongs to the technical field of hair removal, and in particular relates to a nano photothermal material for laser hair removal and a preparation method thereof. Background technique [0002] At present, the most commonly used method of hair removal is laser hair removal, which uses the "selective photothermal effect" of lasers. By reasonably adjusting the pulse width of the laser wavelength and energy, the laser can pass through the surface of the skin to reach the root hair follicles of the hair. The melanin in the hair follicles selectively absorbs light energy and converts it into heat energy. The resulting thermal effect causes the hair follicles to die, and the hair no longer grows. However, hair follicles have a fixed growth cycle, which is divided into growth phase, catagen phase and rest phase. Only the hair follicles in the anagen phase are relatively large and sensitive to light, while the hair follicles in other periods are ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K9/51A61K47/34A61P17/00B82Y5/00B82Y30/00B82Y40/00A61B18/20
CPCA61K41/0052A61K9/5153A61P17/00B82Y5/00B82Y30/00B82Y40/00A61B18/20A61B2018/00452
Inventor 陈晓东黄汶婷王旭升何佳王婧薷杨荣华
Owner THE FIRST PEOPLES HOSPITAL OF FOSHAN
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