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A kind of magnetic dressing and its preparation method and application

A magnetic and magnetic layer technology, applied in bandages, absorbent pads, medical science, etc., can solve the problem of low drug efficacy, achieve low cost, improve therapeutic effect, and achieve controllable release on demand

Active Publication Date: 2022-05-06
SHANGHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

During the drug release process of the micro-nano robot, the released drug does not have direct contact with the lesion. When faced with inflammation of the inner wall of some organs or gastric perforation, the problem of low drug efficacy will appear.

Method used

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  • A kind of magnetic dressing and its preparation method and application
  • A kind of magnetic dressing and its preparation method and application
  • A kind of magnetic dressing and its preparation method and application

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preparation example Construction

[0046]The present invention also provides a preparation method of the magnetic dressing described in the above technical solution, comprising the following steps:

[0047] Prepare the drug-loaded layer;

[0048] Spraying magnetic layer slurry on the surface of the drug-loaded layer to form a magnetic layer, the magnetic layer slurry contains polyvinyl alcohol, gluten and iron particles to obtain a double-layer dressing;

[0049] A protective layer is formed on the surface of the double-layer dressing to obtain the magnetic dressing.

[0050] The invention prepares the drug-loaded layer.

[0051] In the present invention, the drug-loaded layer is preferably prepared by a method comprising the following steps: mixing chitosan, anti-inflammatory drug and water to obtain a hydrogel, and the mass ratio of chitosan and anti-inflammatory drug is preferably 1 :1. The specific limitations of the anti-inflammatory drug in the present invention are preferably consistent with the above...

Embodiment 1

[0072] Chitosan and bismuth potassium citrate were used to prepare the hydrogel as its drug-loading layer at a mass ratio of 1:1.

[0073] The mass ratio of gluten: iron particles: polyvinyl alcohol solution (mass fraction 10%) = 1:8:11, the particle size of iron particles is 6 μm, mix gluten, iron particles and polyvinyl alcohol solution to obtain a magnetic layer Slurry, the magnetic layer slurry is sprayed on the surface of the drug-loaded layer with a thickness of 100 μm, and then cured to form a cured dressing. The cured dressing is bent and placed on the cylindrical surface, the magnetic layer is on the inside, and the drug-loaded layer is on the outside, and it is magnetized (magnetic induction intensity is 10mT), obtain double-layer dressing, put double-layer dressing in sodium alginate solution (mass fraction 6%), then it is transferred in calcium chloride solution (mass fraction 4%), sodium alginate The mass ratio of the solution to the calcium chloride solution is 1...

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Abstract

The invention provides a magnetic dressing and its preparation method and application, which belong to the technical field of pharmaceutical preparations. The invention provides a magnetic dressing, which comprises a magnetic layer, a drug-loaded layer and a protective layer stacked in sequence, and the magnetic layer includes polyvinyl alcohol, gluten and iron particles. The invention uses an external magnetic field to control the swallowed magnetic dressing, and changes the direction of the external magnetic field to move the magnetic dressing to the pathological position. After the external magnetic field is removed, the magnetic dressing changes from a ring shape to a sheet shape, and the attachment of the entire lesion surface is completed. , to complete the treatment by self-releasing medicine.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a magnetic dressing and a preparation method and application thereof. Background technique [0002] Due to the faster and faster pace of life in modern society, people are under great pressure and intensity of study and work. They often eat irregularly, do not eat on time and order, eat less when busy, and overeat when they are free, which leads to gastric ulcer deterioration. Stomach perforation. In recent years, researchers have become more and more active in the research of micro-nano robots, and have developed micro-nano robots with different manufacturing processes and structures, which are widely used in many fields, such as targeted drug delivery, cell capture and separation, 3D tissue assembly etc. At the same time, with the deepening of research, the control methods for the movement of micro-nano robots are also increasingly developed. According to ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/28A61L15/18A61L15/24A61L15/32A61L15/42A61L15/46A61L15/64A61L15/44
CPCA61L15/28A61L15/24A61L15/32A61L15/18A61L15/46A61L15/64A61L15/42A61L15/44A61L2300/21A61L2300/404A61L2300/412A61L2300/604C08L5/08C08L5/04C08L29/04C08L89/00A61F13/0286A61F2013/8479A61L2300/41A61F13/01034A61F13/01029A61F13/01017A61L15/20A61L15/62
Inventor 刘娜陈子衡袁惠宇张丹张珂维岳涛刘媛媛彭艳
Owner SHANGHAI UNIV
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