Bioengineering protein-based biological adhesive and preparation method thereof

A bio-adhesive, bio-engineering technology, applied in microorganism-based methods, peptide preparation methods, biochemical equipment and methods, etc., can solve the problems of low adhesive strength, long preparation time, high price, etc. Low cost, simple preparation method, and pollution-free production process

Inactive Publication Date: 2021-12-10
THE NAVAL MEDICAL UNIV OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] Through the above analysis, the problems and defects of the prior art are: the existing bioadhesives have th

Method used

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  • Bioengineering protein-based biological adhesive and preparation method thereof
  • Bioengineering protein-based biological adhesive and preparation method thereof
  • Bioengineering protein-based biological adhesive and preparation method thereof

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Embodiment Construction

[0030] In order to make the object, technical solution and advantages of the present invention more clear, the present invention will be further described in detail below in conjunction with the examples. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0031] Aiming at the problems existing in the prior art, the present invention provides a biological adhesive based on bioengineering protein and its preparation method. The present invention will be described in detail below with reference to the accompanying drawings.

[0032] The biological adhesive based on the bioengineering protein provided by the embodiment of the present invention consists of 30-50 parts of solvent, 20-35 parts of bioengineering protein, 15-20 parts of chitin whiskers, and 10-20 parts of creeper sucker polysaccharide. 15 parts, 8-12 parts of tannic acid, 6-8 parts of maleylated hyaluronic acid, and ...

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Abstract

The invention belongs to the technical field of biological adhesives, and discloses a bioengineering protein-based biological adhesive and a preparation method thereof. The bioengineering protein-based biological adhesive is prepared from the following components in parts by mass: 30-50 parts of a solvent, 20-35 parts of bioengineering protein, 15-20 parts of chitin whiskers, 10-15 parts of parthenocissus tricuspidata sucker polysaccharide, 8-12 parts of tannic acid, 6-8 parts of maleylated hyaluronic acid and 2-4 parts of a catalyst. According to the bioengineering protein-based biological adhesive provided by the invention, parthenocissus tricuspidata sucker polysaccharide with good biocompatibility is selected as a matrix, and bioengineering protein, tannic acid, maleylated hyaluronic acid and the like are adopted as raw materials, so that the prepared biological adhesive has good biocompatibility, has small irritation to organism tissues, can be firmly adhered to a binding site, and has the characteristics of water resistance, antibacterial property, closed hemostasis and no cytotoxicity; and the preparation method is simple and suitable for large-scale production.

Description

technical field [0001] The invention belongs to the technical field of bioadhesives, in particular to a bioengineered protein-based bioadhesive and a preparation method thereof. Background technique [0002] At present, bioadhesives are biomedical materials prepared from materials with excellent biocompatibility, which are sterile, non-immunogenic, and capable of inhibiting bacteria within a certain period of time. There is no solvent in its components or the solvent is water, and it can still form a certain strength of bonding with body tissues in a wet environment (that is, in the presence of water, interstitial fluid, blood, etc.). The leachables of bioadhesives do not produce toxicity to the body cells, do not affect the wound healing of body tissues, and the material itself is degradable, can be absorbed by human tissues after meeting the requirements of use, and finally be metabolized out of the human body. However, the existing bioadhesives have the disadvantages of ...

Claims

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Application Information

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IPC IPC(8): A61L24/10A61L24/08A61L24/00C12P21/02C07K14/78C07K1/14C08B37/08C08B37/00C12R1/19C12R1/84
CPCA61L24/108A61L24/08A61L24/001A61L24/0015C07K14/78C08B37/003C08B37/0003C08B37/0072A61L2300/404A61L2400/04C08L89/00C08L5/08C08L5/00
Inventor 于兵汪超胡以平
Owner THE NAVAL MEDICAL UNIV OF PLA
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