Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method suitable for industrial scale-up production of mannitol eutectic auxiliary material

A technology of mannitol and crystal excipients, which is applied in the field of medicine, can solve the problems of uneven appearance, complicated process, and low yield, and achieve the effect of simple and easy control of the process, good repeatability, and high yield

Inactive Publication Date: 2021-12-14
CHINA PHARM UNIV
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Based on the traditional suspension crystallization method, the present invention controls the dissolution of raw materials in the suspension, the nucleation and growth of eutectic crystals by exploring suitable parameters, and improves the low yield and uneven morphology in the preparation process. , complex process and other issues, a preparation method suitable for industrial scale-up production of mannitol eutectic excipients is provided, which has the advantages of high yield, simple process, strong versatility, easy process control and less organic solvent consumption, etc., suitable for In the industrial production of this excipient

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method suitable for industrial scale-up production of mannitol eutectic auxiliary material
  • Preparation method suitable for industrial scale-up production of mannitol eutectic auxiliary material
  • Preparation method suitable for industrial scale-up production of mannitol eutectic auxiliary material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] (a) Weigh mannitol powder and solid particles of calcium chloride with a molar ratio of 1:1, and add a certain proportion of ethanol-water solvent

[0025] Weigh 18.24g mannitol and 11.1g anhydrous calcium chloride, add in 250mL solvent (water:ethanol=8:92) to obtain suspension;

[0026] (b) Stir at a constant speed for more than 2 hours at a certain temperature;

[0027] Stir the aforementioned suspension at 25°C for 6 hours at a stirring speed of 200rpm;

[0028] (c) Suction filtration under reduced pressure on the suspension obtained in the previous steps, and drying the obtained solid product to obtain the eutectic

[0029] The suspension obtained in step (b) was subjected to vacuum suction filtration, and the obtained white solid was dried at 40° C. to obtain a solid sample of mannitol calcium chloride cocrystal.

Embodiment 2

[0031] (a) Weigh mannitol powder and solid particles of calcium chloride with a molar ratio of 1:1, and add a certain proportion of ethanol-water solvent

[0032] Weigh 18.24g mannitol and 11.1g anhydrous calcium chloride, add in 250mL solvent (water:ethanol=1:9) to obtain suspension;

[0033] (b) Stir at a constant speed for more than 2 hours at a certain temperature;

[0034] Stir the suspension at 30°C for 4 hours at a stirring speed of 200 rpm;

[0035] (c) Suction filtration under reduced pressure on the suspension obtained in the previous steps, and drying the obtained solid product to obtain the eutectic

[0036] The suspension obtained in step (b) was subjected to vacuum suction filtration, and the obtained white solid was dried at 40° C. to obtain a solid sample of mannitol calcium chloride cocrystal.

[0037] The mannitol calcium chloride eutectic that embodiment 1-2 makes adopts FT-IR spectroscopic characterization, and spectrogram sees attached Figure 1-2 , whi...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a preparation method suitable for industrial scale-up production of a mannitol eutectic auxiliary material, and belongs to the technical field of medicines. The preparation method comprises the following steps of: mixing mannitol with calcium chloride, adding a proper amount of solvent, and stirring to obtain an eutectic crystal. The mannitol eutectic auxiliary material is prepared by using a suspension crystallization method, and the preparation method is high in yield, low in solvent consumption, low in energy consumption and pure in product, and has feasibility of scale-up production .

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a preparation method suitable for industrial scale-up production of mannitol eutectic auxiliary materials. Background technique [0002] Mannitol calcium chloride co-crystal is a new type of co-crystal formed by mannitol and calcium chloride with a coordination bond. The co-crystal contains mannitol, calcium chloride and water in a molar ratio of 1:1:2 (mannitol CaCl 2 2H 2 O), all Ca in the eutectic 2+ Linked together in a 3D coordination network by mannitol molecules. Cheng Hao and others found that compared with β-mannitol, the high bond between molecules in the co-crystal can make the new crystal form have higher binding strength, which significantly improves the compressibility defect of β-mannitol, and is expected to become a new crystal form. A widely used tablet filler (Pharmaceutical Research, 2020, 37, 130); according to Chinese patent CN111166891A, mann...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07F3/04
CPCC07F3/003
Inventor 高缘李祖頔张泽飞张珂张建军钱帅
Owner CHINA PHARM UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com