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Catecholamine specific response type iron-doped carbon nanodot as well as preparation method and application thereof

A carbon nanodot and catecholamine technology, applied in the field of biomedical materials, can solve the problems of difficult localization and diagnosis of pheochromocytoma, difficult timely and effective treatment, limited tumor, etc., and achieves excellent diagnosis and treatment effect, efficient killing, and strong enrichment ability. Effect

Active Publication Date: 2021-12-17
NORTHWESTERN POLYTECHNICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005]The purpose of the present invention is to solve the problem that the existing carbon nano-dot therapy tumors are limited by external light sources. For tumors that are difficult to treat in time and effectively and are prone to relapse after surgery, the technical problem of inability to locate the diagnosis and treatment effect is insufficient. A catecholamine-specific responsive iron-doped carbon nano-dot and its preparation method and application are provided.

Method used

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  • Catecholamine specific response type iron-doped carbon nanodot as well as preparation method and application thereof
  • Catecholamine specific response type iron-doped carbon nanodot as well as preparation method and application thereof
  • Catecholamine specific response type iron-doped carbon nanodot as well as preparation method and application thereof

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Effect test

Embodiment 1

[0042] Example 1: Ferric chloride hexahydrate (67.5mg), sodium acetate (180mg), polyethylene glycol (50mg), ethylene glycol (40ml), citric acid (100mg), urea (200mg) were stirred and mixed The solution was prepared, added to a solvothermal reaction kettle, and heated at 200°C for 8 hours. The resulting mixture solution was centrifuged, and the supernatant was dialyzed, passed through a filter membrane with a pore size of 220 nm, and freeze-dried to prepare catecholamine-responsive iron-doped carbon nanodots.

[0043] The working principle of catecholamine-specific responsive carbon dots in the diagnosis and treatment of pheochromocytoma figure 1 Shown:

[0044] Due to the passive targeting effect of nanomaterials on tumor tissue, iron-doped carbon nanodots are enriched in large quantities in pheochromocytoma. Imaging can determine the distribution of carbon nanodots in the body, and then realize the precise diagnosis and positioning of pheochromocytoma. At the same time, ex...

Embodiment 2

[0048] Embodiment 2: Stir ferric oxide (80mg), polyethylene glycol (50mg), ethylene glycol (40ml), citric acid (100mg), urea (200mg) and stir and mix the preparation solution, add solvothermal reaction kettle in , heated at 200°C for 8 hours. The resulting mixture solution was centrifuged, and the supernatant was dialyzed, passed through a filter membrane with a pore size of 220 nm, and freeze-dried to prepare catecholamine-responsive iron-doped carbon nanodots.

Embodiment 3

[0049] Example 3: Ferric chloride hexahydrate (67.5mg), sodium acetate (180mg), polyethylene glycol (50mg), ethylene glycol (40ml), polyamine (80mg), urea (200mg) were stirred and mixed Prepare the solution, put it into a solvothermal reaction kettle, and heat at 200°C for 8 hours. The resulting mixture solution was centrifuged, and the supernatant was dialyzed, passed through a filter membrane with a pore size of 220 nm, and freeze-dried to prepare catecholamine-responsive iron-doped carbon nanodots.

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Abstract

The invention provides a catecholamine specific response type iron-doped carbon nanodot as well as a preparation method and application thereof, and solves the technical problems that the existing carbon nanodot is limited by an external light source when being used for treating tumors, pheochromocytoma and the like are difficult to locate and diagnose, the tumor is difficult to treat timely and effectively due to easy metastasis, and the tumor which is easy to relapse after operation cannot have a good positioning, diagnosis and treatment effect. The carbon nanodot contains ferrous ions and is prepared from the following components in parts by weight: 20-200 parts of a carbon source, 20-200 parts of an iron source, 20-200 parts of a nitrogen source, 20-200 parts of sodium acetate, 20-200 parts of a passivating agent and 40-160 parts of a solvent.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a catecholamine-specific responsive iron-doped carbon nano-dot and its preparation method and application. Background technique [0002] Because cancer cells are invasive and easy to transfer with the blood, they have the possibility of invasion and enrichment in various organs of the body, which will lead to uncontrolled tissue growth and bring a very dangerous risk of recurrence to traditional treatments such as surgical cutting, chemotherapy, and radiotherapy. and uncertainty. According to the latest global cancer statistics released by the International Agency for Research on Cancer (IARC) of the World Health Organization, there will be 19.29 million new cancer cases and 9.96 million deaths worldwide in 2020. Although anti-tumor research has received extensive attention and research, the current main treatment methods are still surgical resection, chemotherapy...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/65B82Y20/00B82Y30/00B82Y40/00A61K49/00A61K49/06A61K33/44A61P35/00C01B32/15
CPCC09K11/65B82Y20/00B82Y30/00B82Y40/00A61K49/0002A61K49/0019A61K49/06A61K33/44A61P35/00C01B32/15
Inventor 贾庆岩柴进张建红李鹏黄维
Owner NORTHWESTERN POLYTECHNICAL UNIV
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