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A kind of tooth desensitization composition and preparation method thereof

A composition and desensitization technology, applied in the field of oral care, can solve the problems of poor durability of the desensitization effect of tooth desensitization materials, achieve a lasting desensitization effect, and realize the effect of desensitization effect

Active Publication Date: 2022-03-15
诺一迈尔(山东)医学科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The problem solved by the invention is that the desensitization effect of existing tooth desensitization materials is poor in durability

Method used

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  • A kind of tooth desensitization composition and preparation method thereof
  • A kind of tooth desensitization composition and preparation method thereof
  • A kind of tooth desensitization composition and preparation method thereof

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preparation example Construction

[0051] Another object of the present invention is to provide a preparation method of the tooth desensitization composition as described above, the preparation method comprising the steps of:

[0052] S1: Using fluoride, phosphate, surfactant and nerve inhibitor as raw materials, mixing them to prepare component I;

[0053] S2: Preparation of micro-nano bioactive glass;

[0054] S3: Mix micro-nano bioactive glass, hydrophilic solvent, thickener, surfactant, penetrant and nerve inhibitor as raw materials to prepare component II.

[0055] In terms of parts by weight, the preferred amount of each raw material in step S1 of the present application is 0.2-0.5 parts of fluoride, 0.5-1.5 parts of phosphate, 0.5-1.5 parts of surfactant, and 0.5-1 part of nerve inhibitory agent, and a certain amount of acid-base regulator; and preferably, the osmotic pressure of the component I solution is greater than 350mOsm / L, and the pH is 5.0 to 6.0; the addition of each raw material in step S3 is...

Embodiment 1

[0071] This embodiment provides a preparation method of the tooth desensitization composition.

[0072] S1: In parts by weight, 0.2 parts of sodium fluoride, 1.4 parts of anhydrous potassium dihydrogen phosphate, 0.1 part of anhydrous disodium hydrogen phosphate, 1 part of sodium lauryl sulfate, and 0.5 parts of tea tree Oil, 0.35 parts of Tween 80, 0.15 parts of Span 80, mixed to prepare component I; (the phosphates are potassium dihydrogen phosphate and disodium hydrogen phosphate, and part of the potassium dihydrogen phosphate can also have nerve inhibitory effect the role of the agent);

[0073] S2: Preparation of micro-nano bioactive glass:

[0074] S21: Using 22.2g of anhydrous calcium chloride and 33.8g of aluminum chloride hexahydrate as raw materials, add solvent water and mix to prepare 200ml of solution A; the mass ratio of anhydrous calcium chloride to aluminum chloride hexahydrate is 0.66: 1;

[0075] S22: Using 18.4g of sodium tripolyphosphate and 33.9g of sodiu...

Embodiment 2

[0086] This embodiment provides a preparation method of the tooth desensitization composition.

[0087] S1: In parts by weight, mix 0.25 parts of sodium fluoride, 1.2 parts of anhydrous potassium dihydrogen phosphate, 0.08 parts of anhydrous dipotassium hydrogen phosphate, and 1.5 parts of sodium lauryl sulfate to prepare the composition Point I;

[0088] S2: Preparation of micro-nano bioactive glass:

[0089] S21: Using 22.2g of anhydrous calcium chloride and 33.8g of aluminum chloride hexahydrate as raw materials, add solvent water and mix to prepare 200ml of solution A; the mass ratio of anhydrous calcium chloride to aluminum chloride hexahydrate is 0.66: 1;

[0090] S22: Using 18.4g of sodium tripolyphosphate and 33.9g of sodium metasilicate pentahydrate as raw materials, add solvent water and mix to prepare 200ml of solution B; the mass ratio of sodium tripolyphosphate to sodium metasilicate pentahydrate is 0.54: 1;

[0091] S23: Add solution B through a peristaltic p...

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Abstract

The invention provides a tooth desensitization composition and a preparation method thereof, and relates to the technical field of oral care. The tooth desensitization composition includes component I and component II; wherein the component I is a solution; the component I includes fluoride, phosphate and surfactant; said component II is gel or paste; said component II includes micro-nano bioactive glass, hydrophilic solvent, thickener, surfactant and Penetrant. The tooth desensitization composition provided by the present invention utilizes the high-permeability system and the isoelectric point charge attraction principle of dentin collagen, and through the synergistic effect of component I and component II, component I realizes preliminary desensitization and fluoride ion, phosphoric acid Root ion penetration, component II realizes micro-nano bioactive glass infiltration into dentinal tubules, accelerates sealing, realizes depositional occlusion of dentinal tubules, and achieves long-lasting desensitization effect.

Description

technical field [0001] The invention relates to the technical field of oral care, in particular to a tooth desensitization composition and a preparation method thereof. Background technique [0002] The tooth structure consists of enamel, dentin and pulp from the outside to the inside. Dentin tubules with a pore size of about 3 μm are distributed in the dentin. Affect the transmission of dental pulp nerve signals, causing tooth allergy; with enamel defect or gingival recession, the dentin tubules are exposed, and external stimuli directly contact the pulp nerves inside the dentinal tubules, resulting in allergic phenomena such as toothache and toothache. [0003] In addition to medication and surgical treatment, the currently commonly used methods to relieve dentin hypersensitivity are to block dentinal tubules and reduce pulp nerve sensitivity. [0004] The principle of blocking the dentinal tubules is to cut off the pulp nerves and external stimuli, so that the external s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/21A61K8/24A61Q11/00A61K8/20A61K8/25A61K8/26A61K8/55A61K8/92A61K8/98A61P1/02
CPCA61K8/21A61K8/24A61Q11/00A61K8/20A61K8/26A61K8/55A61K8/25A61P1/02A61K8/922A61K8/988
Inventor 朱晓强郭刚李强黄乃进
Owner 诺一迈尔(山东)医学科技有限公司