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Rapid establishment method of periodontitis model and treatment medicine

A technology for treating drugs and establishing methods, applied in the directions of drug combinations, pharmaceutical formulations, plant raw materials, etc., can solve problems such as no report on the therapeutic effect of periodontitis, and achieve the protection of gingival bleeding, improvement of molar loosening, and inhibition of alveolar bone. lost effect

Pending Publication Date: 2021-12-28
KUNMING MEDICAL UNIVERSITY
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  • Application Information

AI Technical Summary

Problems solved by technology

ZL 2017 1 0459344 has described the extraction and purification method of Sanqi neutral polysaccharide and its effect on promoting the proliferation of human periodontal ligament stem cells and mouse osteoblasts in vitro. The therapeutic effect of inflammation has not been reported

Method used

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  • Rapid establishment method of periodontitis model and treatment medicine
  • Rapid establishment method of periodontitis model and treatment medicine
  • Rapid establishment method of periodontitis model and treatment medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Establishment of rat periodontitis model and application of neutral notoginseng polysaccharide to the model

[0019] (1) Model establishment and grouping: Take 30 SPF-grade SD rats, male, 5 weeks old, weighing 100-140 g, and after 2 weeks of adaptive routine feeding, the body weight is about 200 g. 25 rats were randomly selected as the model group to make models of progressive periodontitis, and the remaining 5 rats were used as the normal group (N) without treatment. The method of periodontitis modeling is as follows: the rats were anesthetized with pentobarbital sodium solution (40mg / kg) by intraperitoneal injection, fixed in supine position, the maxillary bilateral second molars were selected, the gingiva was stripped, ligated with 3.0 medical orthodontic steel wire, and as far as possible Make the ligation head in the gingival sulcus. After the ligation is completed, the modeling group is randomly divided into model group, minocycline hydrochloride positive control ...

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Abstract

The invention discloses a rapid establishment method of a periodontitis model and a treatment medicine. A simple rat periodontitis model is successfully obtained through second molars on the two sides of the maxillary of a rat in cooperation with 5-day high-sugar diet. After the rat periodontitis model is established, neutral pseudo-ginseng polysaccharide is applied to the model, a reference basis is provided for comprehensive utilization of pseudo-ginseng resources, after treatment with the neutral pseudo-ginseng polysaccharide, rat inflammation is relieved, alveolar bone loss is remarkably inhibited, and gingival bleeding is greatly protected; and the new application of the neutral pseudo-ginseng polysaccharide in periodontitis treatment is added, and biological research on treatment of periodontitis by the neutral pseudo-ginseng polysaccharide is provided.

Description

technical field [0001] The invention relates to the application field of natural products of Panax notoginseng, in particular to a method for quickly establishing a periodontitis model and a therapeutic drug. Background technique [0002] Periodontitis is a common chronic infectious disease, which is very common and prevalent in oral diseases. It is characterized by the attachment of connective tissue and the loss of alveolar bone, often accompanied by symptoms such as loose teeth and bleeding gums. It is the cause of tooth loss in adults. The main reason is that nowadays, many studies have confirmed that the initiating factor of periodontitis is the accumulation of plaque biofilm around the gums, which in turn triggers a host immune response mediated by a series of inflammatory cytokines. During the pathological process of periodontitis, the level of IL-1β is high, which can promote the proliferation and activation of osteoclasts, and participate in the destruction of perio...

Claims

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Application Information

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IPC IPC(8): A01K67/027A61K31/715A61K36/258A61P1/02
CPCA01K67/027A61K31/715A61K36/258A61P1/02A01K2267/0368
Inventor 陈彤唐祥李怀宇
Owner KUNMING MEDICAL UNIVERSITY
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