Wound surface liquid dressing and preparation method thereof

A wound surface liquid and system technology, which is applied to the preparation of several thousand words of wound liquid dressing, liquid dressing and its preparation field, can solve the problems that the Band-Aid film cannot meet the waterproofness and air permeability at the same time, the active ingredients are not clear, the formula is complicated, etc. Anti-inflammatory and healing effect, good breathability, simple formula effect

Active Publication Date: 2021-12-28
WUFENG CHICHENG BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The purpose of the present invention is to solve the technical defects of existing liquid band-aids such as complicated formula, unclear active ingredients, mostly synthetic or semi-synthetic chemicals in film-forming substrates, and formation of band-aid films that cannot simultaneously satisfy good water resistance and air permeability. A wound liquid dressing and a preparation method thereof are provided. The wound liquid dressing of the present invention quickly forms a film on the skin surface, and has good bacteria resistance, air permeability and liquid absorption, and has good anti-inflammatory and healing effects on wounds. The healing speed is fast, the healing rate is high, it meets the relevant requirements of the national standard, meets the needs of wound liquid dressings in daily life and medical treatment, and has a good application prospect

Method used

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  • Wound surface liquid dressing and preparation method thereof
  • Wound surface liquid dressing and preparation method thereof
  • Wound surface liquid dressing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1A

[0067] Embodiment 1A synthetic compound GA-C 28

[0068] 1. Accurately weigh gallic acid monohydrate (2.26g, 12.0mmol) and n-octacosanol (1.65g, 4.0mmol), and add them to a two-necked bottle with a water separator and a thermometer, wherein gallic acid and n-octacosanol The molar ratio of octacosanol is 3:1;

[0069] In the embodiment of the present invention, the molar ratio of gallic acid to n-octacosanol is 3:1 as an example, and other molar ratios (2-4.5):1 are also applicable to the present invention.

[0070] 2. Accurately measure 20.0mL (usually 15.0-35.0mL) of 1,4-dioxane solvent and add it to the two-necked bottle;

[0071] Usually the ratio of the amount of solvent to octacosanol is 9-22:1, that is, the liquid-solid ratio of solvent to octacosanol is 9-22:1, that is, the volume of solvent to the mass of octacosanol The ratio is 9-22:1, and every 1g of octacosanol is dissolved with 9-22ml of solvent; the liquid-solid ratio of the amount of solvent to gallic acid is...

Embodiment 1

[0084] Weigh a certain quality of bleached shellac, plasticizer PEG1k, GA-C 28 ; Mix bleached shellac, PEG1K, GA-C with stirring 28 Add to 15.0mL of absolute ethanol, stir and heat the mixture to 45°C (usually 35-50°C), and stir and mix for 2.5h (usually 2-4h) while maintaining the temperature at 45°C; then add 5.0mL The ethyl acetate dissolves the solid completely; after the mixed solution is naturally cooled to room temperature, the wound liquid dressing of the present invention is obtained;

[0085] In the present embodiment, the addition amount of control plasticizer PEG1k is 0.40g, GA-C 28 The addition amount of 0.03g, and the addition amount of bleached shellac were 1.00, 1.40, 1.80, 2.20, 2.60g, respectively, to prepare 5 liquid wound dressing samples (named samples 1-5), and each treatment was repeated 3 times.

[0086] Use the NDJ-8S rotational viscometer (Shanghai Jingke Industrial Co., Ltd.) to measure the viscosity of the wound liquid dressing prepared in Example...

Embodiment 2

[0090] Weigh a certain quality of bleached shellac, plasticizer PEG1k, GA-C 28 ; Mix bleached shellac, PEG1K, GA-C with stirring 28 Add to 15.0mL of absolute ethanol, stir and heat the mixture to 45°C (usually 35-50°C), and stir and mix for 2.5h (usually 2-4h) while maintaining the temperature at 45°C; then add 5.0mL The ethyl acetate dissolves the solid completely; after the mixed solution is naturally cooled to room temperature, the wound liquid dressing of the present invention is obtained;

[0091] In the present embodiment, the addition amount of control bleaching shellac is 1.80g, GA-C 28 The addition amount of 0.03g, the addition amount of plasticizer is 0.40g, the plasticizer chooses PEG1k, PEG2k, PEG4k, PEG10k, PVA, PVP respectively, prepares 6 liquid dressing samples, each treatment repeats 3 times. The sample without plasticizer was set as blank control.

[0092] Accurately measure 5.0 mL each of the 6 liquid dressings prepared in Example 2, spread them on a 9.0 ...

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Abstract

The invention discloses a wound surface liquid dressing and a preparation method thereof; the liquid dressing comprises bleached shellac, a plasticizer, gallate octacosyl ester (GA-C28) and a solvent system; the liquid dressing disclosed by the invention is a spraying type GA-C28/bleached shellac wound surface liquid dressing prepared by taking the GA-C28 as an active component and taking the natural, nontoxic and degradable bleached shellac as a film-forming matrix; and the spraying type GA-C28/bleached shellac wound surface liquid dressing can quickly form a film on the surface of skin, has good film permeability and liquid absorbability, has certain deformation resistance, has good anti-inflammatory and healing effects on wounds, is high in wound surface healing speed and healing rate, meets relevant requirements of national standards, satisfies the requirements on the wound surface liquid dressing in daily life and medical treatment, and has better the application prospect. The preparation method of the liquid dressing disclosed by the invention is simple to operate, mild in process condition and suitable for industrial large-scale production.

Description

technical field [0001] The invention relates to a liquid dressing and a preparation method thereof, in particular to a preparation method of a wound liquid dressing and belongs to the technical field of medicine preparation. Background technique [0002] Superficial skin injuries such as minor skin scratches, cuts, contusions and burns are very common in daily life, and the use of band-aids is the most commonly used nursing method. Wound liquid dressing is a new type of band-aid that can disinfect wounds and promote wound healing. It is a new type of band-aid that can be used instead of ordinary band-aids when cuts, abrasions, cracks, chaps and other wounds appear. It is a biofilm-forming disinfectant. Wound liquid dressings are applied by spraying or smearing, forming a protective film on the wound, combining the continuous disinfection and protection functions of the wound, and having good bactericidal properties. Compared with traditional liquid band-aids, they are more ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00
CPCA61L26/0066A61L26/00A61L26/0019A61L26/0057A61L26/0061A61L2300/412A61L2300/41A61L2300/404A61L2300/216C08L71/02
Inventor 刘兰香张弘陈赤清毛业富刘义稳战祥宁然谢山宇
Owner WUFENG CHICHENG BIOTECH
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