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Preparation method of stent with anticoagulation coating and stent

An anticoagulant and coating technology, applied in the field of vascular stents, can solve problems such as large contact area, insignificant modification effect, and neurological impairment of patients

Pending Publication Date: 2021-12-31
成都百瑞恒通医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The nickel-titanium alloy dense-mesh stent currently used in clinical practice still has some outstanding problems: First, after the stent is implanted, due to the large contact area between the stent and the blood flow, it is easy to cause the adhesion and activation of platelets on the dense-mesh stent to form a thrombus, which in turn leads to Cerebral insufficiency, cerebral infarction and other risks
Second, the risk of bleeding in the middle and late stages of implantation is relatively increased. Idiopathic intracerebral hemorrhage (IPH) is the most terrible complication after implantation, which may cause serious neurological damage or even death to the patient.
However, there are still problems such as less research and insignificant modification effect

Method used

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  • Preparation method of stent with anticoagulation coating and stent
  • Preparation method of stent with anticoagulation coating and stent
  • Preparation method of stent with anticoagulation coating and stent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The method of preparing the bracket having an anticoagulant coating layer includes the step of preparing as follows:

[0029] (1) Cleaning the nickel-titanium alloy and nickel and titanium scientic bracket and dry;

[0030] (2) The sample obtained by step (1) was immersed in the concentration of 0.5% silane coupling solution (KH550) under normal temperature conditions, and the pH was added to 3.5, and the immersion time was 2 h, and washed and washed and dried;

[0031] (3) The sample obtained in step (2) was immersed in a normal temperature condition, and 0.01 mg / ml of an aspirin solution and 0.01 mM of a copper chloride solution, alternately deposited 3 times, 15 min each time, remove the cleaning drying.

Embodiment 2

[0033] The method of preparing the bracket having an anticoagulant coating layer includes the step of preparing as follows:

[0034] (1) Cleaning the nickel-titanium alloy and nickel and titanium scientic bracket and dry;

[0035] (2) The sample obtained by step (1) was immersed in the concentration of 3% silane coupling solution (KH550) under normal temperature conditions, and a acetic acid was added to 3.5, and the immersion did not have a time of 2 h, and washed and washed and dried;

[0036] (3) The sample obtained in step (2) was immersed in a normal temperature condition, and 0.01 mg / ml of an aspirin solution and 0.01 mM of a copper chloride solution, alternately deposited 3 times, 15 min each time, remove the cleaning drying.

Embodiment 3

[0038] The method of preparing the bracket having an anticoagulant coating layer includes the step of preparing as follows:

[0039] (1) Cleaning the nickel-titanium alloy and nickel and titanium scientic bracket and dry;

[0040] (2) The sample obtained by step (1) was immersed in the concentration of 3% silane coupling solution (KH550) under normal temperature conditions, and the pH was added to 5.5, and the immersion time was 2 h, and washed and washed and dried;

[0041] (3) The sample obtained in step (2) was immersed in a normal temperature condition, and 0.01 mg / ml of an aspirin solution and 0.01 mM of a copper chloride solution, alternately deposited 3 times, 15 min each time, remove the cleaning drying.

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Abstract

The invention relates to an intravascular stent, and provides a preparation method of a stent with an anticoagulation coating. The preparation method comprises the following preparation steps: (1) cleaning and drying an alloy sheet and an alloy stent; (2) immersing the sample in the step (1) in a silane coupling agent solution, adjusting the pH value to 3.5-5.5 and the immersion time to 1.5-2.5 hours, then taking out the sample, and performing cleaning and drying; and (3) alternately immersing the sample in the step (2) in an anticoagulant drug and a solution containing copper ions respectively, then taking out the sample, and performing cleaning and drying. The invention further provides the stent prepared based on the preparation method. According to the preparation method of the stent with the anticoagulant coating, the stent has remarkable anticoagulant performance.

Description

Technical field [0001] The present invention relates to the technical field of vascular brackets, and in particular, therefore a method and a bracket having a stent having an anticoagulant coating. Background technique [0002] Animalioma is a more common cardiovascular disease. It is mainly due to the performance of the arterial blood vessel wall itself or damage, formation of arterial wall limitations or diffuse expansion or bulging performance, with expansion, pulsating mass, the aneurysm is "Timed Bomb" in patients, at any time It may be ruptured, and it is easy to generate large bleeding threats to the health of the patient. For the treatment of aneurysms, there is mainly: First, traditional surgical clamps; the second is the binding application of the implantation or secret network bracket and the combination of the two. Surgery has a large risk, large trauma and complications, general circumstances and doctors will be carefully selected. Neurological intervention spring ri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/08A61L31/02A61L31/16A61L33/00A61L33/10A61L33/04A61B17/12
CPCA61L31/08A61L31/088A61L31/022A61L31/16A61L33/0041A61L33/0088A61L33/0082A61L33/08A61L33/04A61B17/12118A61B17/12177A61L2300/42A61L2300/606A61L2300/602A61L2400/18A61L2420/02A61L2420/04C08L5/10
Inventor 高飞徐兰馨
Owner 成都百瑞恒通医疗科技有限公司
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