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Preparation method of polyimide novel material with anticoagulant function

A polyimide and polyimide resin technology, applied in the field of material preparation, can solve the problems of limited application and no anticoagulant effect, etc.

Inactive Publication Date: 2019-01-18
张玲
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The superior comprehensive performance of polyimide endows it with the potential as a biomedical material, especially the hemocompatible material that is in direct contact with blood, but the polyimide material prepared by the above patents and the prior art does not have anticoagulation blood effect, limiting its application in blood compatible materials

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] A preparation method of a new polyimide material with anticoagulant function, the preparation technical scheme is as follows:

[0019] According to the mass parts, add 18 parts of polyethylene glycol and 150 parts of dimethyl sulfoxide to the reaction kettle, stir evenly, control the temperature at 60°C, and then add 70 parts of two sultone compounds containing 5 parts of sultone. The methyl sulfoxide solution was added dropwise to the reaction kettle, and the addition was completed within 40 minutes. The reaction was stirred for 3 hours, and then cooled to room temperature to obtain an intermediate solution for use; 13 parts of cerium-containing polyimide resin powder, 0.3 Add parts of aluminum chloride powder and 150 parts of dimethyl sulfoxide into the reaction kettle, under the protection of nitrogen, heat up to 50°C, stir evenly, add the above intermediate solution dropwise to the reaction kettle, after the addition is complete The temperature is controlled at 70°C, t...

Embodiment 2

[0027] A preparation method of a new polyimide material with anticoagulant function, the preparation technical scheme is as follows:

[0028] According to the mass parts, 15 parts of polyethylene glycol and 100 parts of dimethyl sulfoxide were added to the reaction kettle. After stirring, the temperature was controlled at 50°C, and then 60 parts containing 2 parts of sultone compound The methyl sulfoxide solution was added dropwise to the reaction kettle, and the addition was completed within 30 minutes. The reaction was stirred for 1 hour, and then cooled to room temperature to obtain an intermediate solution for use; 10 parts of cerium-containing polyimide resin powder, 0.1 Add parts of aluminum chloride powder and 100 parts of dimethyl sulfoxide into the reaction kettle, under the protection of nitrogen, heat up to 40°C, stir evenly, add the above intermediate solution dropwise to the reaction kettle, after the addition is complete The temperature is controlled at 60°C, the re...

Embodiment 3

[0036] A preparation method of a new polyimide material with anticoagulant function, the preparation technical scheme is as follows:

[0037] According to the mass parts, 20 parts of polyethylene glycol and 200 parts of dimethyl sulfoxide were added to the reactor, after stirring uniformly, the temperature was controlled at 70°C, and then 80 parts of two sultone compounds containing 8 parts were added. The methyl sulfoxide solution was added dropwise to the reaction kettle, and the addition was completed within 60 minutes. The reaction was stirred for 5 hours, and then cooled to room temperature to obtain an intermediate solution for use; 15 parts of cerium-containing polyimide resin powder, 0.5 Add parts of aluminum chloride powder and 200 parts of dimethyl sulfoxide into the reaction kettle, under the protection of nitrogen, heat up to 60℃, stir evenly, add the above intermediate solution dropwise to the reaction kettle, after the addition is complete The temperature is control...

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PUM

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Abstract

The invention discloses a preparation method of a polyimide novel material with an anticoagulant function. The method first adopts 4,4-(4,4-Isopropylidenediphenoxy)bis(phthalic anhydride) to react with polyether amine and then adopts 3,3-iminobis(N,N-dimethylpropylamine) for blocking ends, thereby preparing powder containing cerium polyimide resin; then polyethylene glycol and a sulfonic lactone compound are used for preparing sulfonated polyethylene glycol, which is then grafted to the molecule of polyimide resin for preparing the polyimide novel material with the anticoagulant function. Thematerial has excellent solubility and good thermal stability, effectively improves the blood compatibility, greatly prolongs the coagulation time in vitro and the recalcification coagulation time anddoes not have any hemolytic action, thereby being a promising blood compatible material.

Description

Technical field [0001] The invention relates to the field of material preparation, in particular to a preparation method of a new polyimide material with anticoagulant function. Background technique [0002] Polyimide refers to an aromatic heterocyclic polymer compound containing imide-based chains in the molecular structure. Because of its high temperature resistance, radiation resistance, good dielectric properties, and excellent mechanical properties, it is used in the aerospace industry, membrane separation Industry, liquid crystal display, optoelectronic materials, biocompatible materials, microelectronics industry and many other fields have very wide applications. [0003] CN101495548A discloses a polyimide film formed of a multi-component polyimide formed of two or more different polyimide components. The multi-component polyimide is, for example, composed of polyimide component A and polyimide The imide component B is formed. The polyimide component A is the raw material c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G81/00A61L33/06
CPCA61L33/0011A61L33/068C08G81/00C08L87/00
Inventor 张玲王金霞
Owner 张玲
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