Antibacterial bone cement and preparation method thereof

An antibacterial bone and bone cement technology, used in medical science, tissue regeneration, prosthesis, etc., can solve the problems of lack of biological activity, hinder bacterial DNA replication, and cannot degrade and absorb, and achieve the effect of enhancing biological activity.

Pending Publication Date: 2022-01-04
山东明德生物医学工程有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has the advantages of high mechanical strength and fast curing speed, but it also has significant defects: the elastic modulus is 4 to 40 times that of the vertebral cancellous bone, and the high elastic modulus leads to excessive increase in the hardness of the formed vertebral body, resulting in Stress concentration, which in turn causes adjacent vertebral bodies to compress and fracture again; lacks biological activity, cannot be degraded and absorbed, and exists in the vertebral body in the form of foreign bodies for a long time, etc.
Studies have shown that silver ions can penetrate the cell wall of bacteria, and can cause bacterial DNA structure denaturation, hinder bacterial DNA replication, and cause bacterial death
However, there is no report on the direct use of silver salts to reduce silver in the process of bone cement preparation to enhance the antibacterial properties of bone cement.

Method used

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  • Antibacterial bone cement and preparation method thereof

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Effect test

Embodiment 1

[0021] An antibacterial bone cement, mainly composed of the following raw materials in mass percentage: the powder is 55% of polyacrylate, 40% of silver and barium sulfate composite powder, and 5% of benzoyl peroxide; the liquid is N, N-dimethyl 0.5% of p-toluidine, 0.05% of hydroquinone, and 99.45% of methyl methacrylate; in the composite powder of silver and barium sulfate, Ag accounts for 0.5% by mass of the composite powder of silver and barium sulfate.

[0022] The preparation method of the antibacterial bone cement of the present embodiment comprises the steps:

[0023] S1, preparation mass percent is the silver nitrate solution of 1.57%;

[0024] S2. Add barium sulfate powder into the silver nitrate solution and mix for 60 minutes, wherein the mass ratio of barium sulfate to silver nitrate solution is 2:1;

[0025] S3, drying in an oven at 120° C. for 5 hours, and ball milling after drying to obtain silver nitrate / barium sulfate composite powder with a thickness of 0.5...

Embodiment 2

[0031] An antibacterial bone cement, mainly composed of the following raw materials in mass percentage: the powder is 89% of polyacrylate, 10% of silver and barium sulfate composite powder, 1% of benzoyl peroxide; the liquid is N, N-dimethyl 5% p-toluidine, 2% hydroquinone, and 93% methyl methacrylate; in the silver and barium sulfate composite powder, Ag accounts for 5% of the mass percentage of the silver and barium sulfate composite powder.

[0032] The preparation method of the antibacterial bone cement in the present embodiment comprises the steps:

[0033] S1, preparation mass percentage is the silver nitrate solution of 20%;

[0034] S2. Add the barium sulfate powder into the silver nitrate solution and mix for 30 minutes, wherein the mass ratio of the barium sulfate to the silver nitrate solution is 2.54:1;

[0035] S3, drying in an oven at 60° C. for 24 hours, and ball milling after drying to obtain a silver nitrate / barium sulfate composite powder of 0.5-45 μm;

[0...

Embodiment 3

[0040] An antibacterial bone cement, mainly composed of the following raw materials in mass percentage: the powder is 68% of polyacrylate, 30% of silver and barium sulfate composite powder, 2% of benzoyl peroxide; the liquid is N, N-dimethyl 2% p-toluidine, 0.1% hydroquinone, 97.9% methyl methacrylate. In the composite powder of silver and barium sulfate, Ag accounts for 1% by mass of the composite powder of silver and barium sulfate.

[0041] The preparation method of the antibacterial bone cement of the present embodiment comprises the steps:

[0042] S1, preparation mass percent is the silver nitrate solution of 4.78%;

[0043] S2. Add barium sulfate powder into the silver nitrate solution and mix for 30 minutes, wherein the mass ratio of barium sulfate to silver nitrate solution is 3:1;

[0044] S3, drying in an oven at 100° C. for 24 hours, and ball milling after drying to obtain a silver nitrate / barium sulfate composite powder of 0.5-45 μm;

[0045] S4. Transfer the s...

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Abstract

The invention relates to the technical field of biomedical materials, in particular to antibacterial bone cement and a preparation method thereof. The antibacterial bone cement is mainly prepared by mixing powder with liquid according to an addition ratio of (1-3) g: 1mL, wherein the powder mainly consists of the following raw materials in percentage by mass: 55-89% of polyacrylate, 10-40% of silver and barium sulfate composite powder and 1-5% of benzoyl peroxide; and the liquid mainly consists of the following raw materials in percentage by mass: 0.5-5% of N, N-dimethyl p-toluidine, 0.05-2% of hydroquinone and 93-99.45% of methyl methacrylate. Silver and barium sulfate are compounded and then added into PMMA, silver elements are evenly dispersed, and the antibacterial bone cement has the advantages of being good in antibacterial property and high in strength, and besides, has good biocompatibility and bone regeneration performance.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to an antibacterial bone cement and a preparation method thereof. Background technique [0002] Acrylic resin bone cement (PMMA) is the most widely used bone cement in clinical practice. It has the advantages of high mechanical strength and fast curing speed, but it also has significant defects: the elastic modulus is 4 to 40 times that of the vertebral cancellous bone, and the high elastic modulus leads to excessive increase in the hardness of the formed vertebral body, resulting in Stress concentration causes the adjacent vertebral body to compress and fracture again; it lacks biological activity, cannot be degraded and absorbed, and exists in the vertebral body in the form of foreign bodies for a long time. In order to overcome the defects of PMMA, alternative materials including calcium phosphate bone cement, calcium sulfate bone cement and their composite bone cem...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/04A61L27/02A61L27/16A61L27/54A61L27/50
CPCA61L27/047A61L27/025A61L27/16A61L27/54A61L27/50A61L2430/02A61L2300/104A61L2300/404C08L33/02
Inventor 李朝阳崔永顺刘春芳吕维加
Owner 山东明德生物医学工程有限公司
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