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3D printing-based personalized knee joint local tissue partition shaping system and method

A 3D printing and local tissue technology, applied in the field of 3D printing molds, can solve the problems of inability to gel, precisely control the shape of the gel, etc., and achieve the effects of low difficulty, complete scheme system, and simple operation

Active Publication Date: 2022-03-01
PEKING UNIV THIRD HOSPITAL +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In view of the above analysis, the embodiment of the present invention aims to provide a 3D printing-based personalized knee joint local tissue partition shaping system and method to solve the problem that the existing technology cannot form a gel in a specific area around the tissue engineering scaffold and precisely control it. Gel Form Problems

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  • 3D printing-based personalized knee joint local tissue partition shaping system and method
  • 3D printing-based personalized knee joint local tissue partition shaping system and method
  • 3D printing-based personalized knee joint local tissue partition shaping system and method

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Embodiment 1

[0050] A specific embodiment of the present invention, such as Figure 1-Figure 3 As shown, a 3D printing-based personalized knee joint local tissue partition shaping system is disclosed, including a gradient tissue engineering scaffold 100, a lateral shaping device 200 and a medial shaping device 300, and the gradient tissue engineering scaffold 100 is sequentially shaped on the lateral side Glue is formed in the device 200 and the inner shaping device 300 .

[0051] In this embodiment, the 3D printing material of the outer shaping device 200 and the inner shaping device 300 is metal.

[0052] The gradient tissue engineering scaffold 100 has a gradient porous and loose structure, which is designed according to the tissue morphology of a specific area of ​​the patient and processed by 3D printing technology from biomaterials. The biomaterials are preferably polycaprolactone materials that can be degraded in vivo.

[0053] When the meniscus tissue is taken as a typical example...

Embodiment 2

[0097] A specific embodiment of the present invention, such as Figure 1-Figure 16 As shown, a 3D printing-based personalized knee joint local tissue zoning shaping method is disclosed, using the 3D printing-based personalized knee joint local tissue zoning shaping system of Embodiment 1, the steps include:

[0098]S1: Obtain image information of the damaged part of the patient through CT (Computed Tomography, computerized tomography) or MRI (Magnetic Resonance Imaging, magnetic resonance imaging), for example, the damaged part of the meniscus tissue is extracted through medical image software 3D structure, and repair the shape of the damaged part in the modeling software, and output the repaired 3D graphics.

[0099] S2: According to the actual needs, the three-dimensional graphics of the repaired local tissue are divided, and the different parts after the division are input into the 3D printing device, and different printing parameters are assigned to each part to achieve di...

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Abstract

The invention relates to a 3D printing-based personalized knee joint local tissue partition shaping system and method, which belongs to the technical field of 3D printing molds, and solves the problem in the prior art that it is impossible to form a specific area of ​​gel around the tissue engineering bracket and precisely control the shape of the gel question. The present invention comprises a gradient tissue engineering support, an outer shaping device and an inner shaping device, and the gradient tissue engineering support is glued in the outer shaping device and the inner shaping device sequentially. The invention realizes the design and manufacture of gradient porous tissue engineering scaffolds, and at the same time, through two sets of fixtures and shaping molds combined with two-component mixing gelation technology, the hydrogel containing two different growth factors can be shaped in partitions to finally form a complete The hydrogel-wrapped scaffold structure can realize tissue engineering reconstruction of complex shape and multi-factor directional growth; highly customized solution, complete solution system, simple operation, low difficulty in design and manufacture, and low cost.

Description

technical field [0001] The invention relates to the technical field of 3D printing molds, in particular to a system and method for shaping individualized knee joint local tissue partitions based on 3D printing. Background technique [0002] The technology of using 3D printed tissue engineering scaffolds for human tissue regeneration has not yet formed a large-scale market application, and there are still many key technologies to be solved. For example, in the meniscus tissue engineering reconstruction technology, it is still difficult to realize the division and directed differentiation of stem cells . [0003] At present, the existing technology can combine two components 4-arm-PEG-NH2-20K (4-arm-Poly(ethyleneglycol) amine-20K, 4-arm-polyethylene glycol-amino-20,000) and 4-arm - PEG-SC-20 K (4-arm-Poly(ethylene glycol) succinimidyl ester-20K, 4-arm-polyethylene glycol-succinimidyl carbonate-20,000) solution is mixed according to a certain ratio to form a gel , Inject diff...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B29C64/106B29C64/20B29C64/336B29C64/255B29C64/314B29C64/386B29C64/393B33Y10/00B33Y30/00B33Y40/00B33Y40/10B33Y50/00B33Y50/02B33Y70/10B33Y80/00A61L27/18A61L27/22A61L27/54A61L27/52
CPCB29C64/106B29C64/20B29C64/336B29C64/255B29C64/314B29C64/386B29C64/393B33Y10/00B33Y30/00B33Y40/00B33Y40/10B33Y50/00B33Y50/02B33Y70/10B33Y80/00A61L27/18A61L27/227A61L27/54A61L27/52A61L2300/414A61L2430/24C08L71/02
Inventor 余家阔许冰冰王星叶景
Owner PEKING UNIV THIRD HOSPITAL