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Personalized knee joint local tissue partition shaping system and method based on 3D printing

A 3D printing and local tissue technology, applied in the field of 3D printing molds, can solve the problems of inability to gel and precisely control the shape of the gel, achieving the effect of low difficulty, complete scheme system and low cost

Active Publication Date: 2022-01-07
PEKING UNIV THIRD HOSPITAL +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In view of the above analysis, the embodiment of the present invention aims to provide a 3D printing-based personalized knee joint local tissue partition shaping system and method to solve the problem that the existing technology cannot form a gel in a specific area around the tissue engineering scaffold and precisely control it. Gel Form Problems

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  • Personalized knee joint local tissue partition shaping system and method based on 3D printing
  • Personalized knee joint local tissue partition shaping system and method based on 3D printing
  • Personalized knee joint local tissue partition shaping system and method based on 3D printing

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Embodiment 1

[0050] A specific embodiment of the present invention, such as Figure 1-Figure 3 As shown, a 3D printing-based personalized knee joint local tissue partition shaping system is disclosed, including a gradient tissue engineering scaffold 100, a lateral shaping device 200 and a medial shaping device 300, and the gradient tissue engineering scaffold 100 is sequentially shaped on the lateral side Glue is formed in the device 200 and the inner shaping device 300 .

[0051] In this embodiment, the 3D printing material of the outer shaping device 200 and the inner shaping device 300 is metal.

[0052] The gradient tissue engineering scaffold 100 has a gradient porous and loose structure, which is designed according to the tissue morphology of a specific area of ​​the patient and processed by 3D printing technology from biomaterials. The biomaterials are preferably polycaprolactone materials that can be degraded in vivo.

[0053] When the meniscus tissue is taken as a typical example...

Embodiment 2

[0097] A specific embodiment of the present invention, such as Figure 1-Figure 16 As shown, a 3D printing-based personalized knee joint local tissue zoning shaping method is disclosed, using the 3D printing-based personalized knee joint local tissue zoning shaping system of Embodiment 1, the steps include:

[0098]S1: Obtain image information of the damaged part of the patient through CT (Computed Tomography, computerized tomography) or MRI (Magnetic Resonance Imaging, magnetic resonance imaging), for example, the damaged part of the meniscus tissue is extracted through medical image software 3D structure, and repair the shape of the damaged part in the modeling software, and output the repaired 3D graphics.

[0099] S2: According to the actual needs, the three-dimensional graphics of the repaired local tissue are divided, and the different parts after the division are input into the 3D printing device, and different printing parameters are assigned to each part to achieve di...

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Abstract

The invention relates to a personalized knee joint local tissue partition shaping system and method based on 3D printing, and belongs to the technical field of 3D printing molds. The system and the method solve the problems that in the prior art, specific area gel cannot be formed around a tissue engineering scaffold, and the gel form cannot be accurately controlled. The system comprises a gradient tissue engineering scaffold, an outer side shaping device and an inner side shaping device, and the gradient tissue engineering scaffold forms gel in the outer side shaping device and the inner side shaping device in sequence. According to the system and the method, the design and manufacturing of the gradient porous tissue engineering scaffold are realized, hydrogel containing two different growth factors is shaped in a partitioned manner through two groups of clamps and shaping molds in combination with a bi-component mixing gel forming technology, so that a complete scaffold structure wrapped by the hydrogel is finally formed, and tissue engineering reconstruction of complex-shape multi-factor directional growth can be realized; and the scheme is highly customized, the scheme system is perfect, the operation is simple, the design and manufacturing difficulty is small, and the cost is low.

Description

technical field [0001] The invention relates to the technical field of 3D printing molds, in particular to a system and method for shaping individualized knee joint local tissue partitions based on 3D printing. Background technique [0002] The technology of using 3D printed tissue engineering scaffolds for human tissue regeneration has not yet formed a large-scale market application, and there are still many key technologies to be solved. For example, in the meniscus tissue engineering reconstruction technology, it is still difficult to realize the division and directed differentiation of stem cells . [0003] At present, the existing technology can combine two components 4-arm-PEG-NH2-20K (4-arm-Poly(ethyleneglycol) amine-20K, 4-arm-polyethylene glycol-amino-20,000) and 4-arm - PEG-SC-20 K (4-arm-Poly(ethylene glycol) succinimidyl ester-20K, 4-arm-polyethylene glycol-succinimidyl carbonate-20,000) solution is mixed according to a certain ratio to form a gel , Inject diff...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B29C64/106B29C64/20B29C64/336B29C64/255B29C64/314B29C64/386B29C64/393B33Y10/00B33Y30/00B33Y40/00B33Y40/10B33Y50/00B33Y50/02B33Y70/10B33Y80/00A61L27/18A61L27/22A61L27/54A61L27/52
CPCB29C64/106B29C64/20B29C64/336B29C64/255B29C64/314B29C64/386B29C64/393B33Y10/00B33Y30/00B33Y40/00B33Y40/10B33Y50/00B33Y50/02B33Y70/10B33Y80/00A61L27/18A61L27/227A61L27/54A61L27/52A61L2300/414A61L2430/24C08L71/02
Inventor 余家阔许冰冰王星叶景
Owner PEKING UNIV THIRD HOSPITAL