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Enalapril maleate and furosemide compound tablet, preparation method and application thereof

A technology of enalapril maleate and compound tablets, which is applied in the fields of pill delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc., to achieve the effects of ensuring stability, low production cost, and ensuring convenience

Pending Publication Date: 2022-02-08
上海汉维生物医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, combining these two drug ingredients in one fixed dosage form is a technical challenge

Method used

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  • Enalapril maleate and furosemide compound tablet, preparation method and application thereof
  • Enalapril maleate and furosemide compound tablet, preparation method and application thereof
  • Enalapril maleate and furosemide compound tablet, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0076] The preparation method of enalapril maleate and furosemide compound tablet of the present invention comprises the steps:

[0077] (1) Preparation of the mixed material of enalapril maleate drug-containing layer: after heating and melting the low melting point auxiliary material, add enalapril maleate powder and stir to mix evenly. It is then prepared into granules / powder by hot melt spray cooling granulation equipment. The twin-screw barrel of the hot-melt spray cooling granulation equipment transports the melted drug suspension to the two-fluid airflow spray gun, and then atomizes it into droplets through compressed air, fully contacts with the ultra-low temperature frozen air, and instantly condenses and solidifies. Part of the condensed particles settle into the collection bucket at the bottom of the drying chamber along with the airflow, and the tail gas passes through the dust removal device to complete the secondary separation of gas and solid to collect the produ...

Embodiment 1

[0086] The compound tablet of enalapril maleate and furosemide in this embodiment includes 2.5 g of enalapril maleate and 25 g of furosemide.

[0087] The compound tablet prescription of the present embodiment is as shown in table 1.

[0088] Table 1 Embodiment 1 prescription list (1000 tablets)

[0089]

[0090]

[0091] *: Solvent for adhesive, removed during production.

[0092] The preparation method of enalapril maleate and furosemide compound tablet of the present embodiment comprises the steps:

[0093] (1), the preparation of the mixed material of enalapril maleate drug-containing layer:

[0094] (a) PEG 3350 is heated to 60°C and all of it melts into a liquid.

[0095] (b) Enalapril maleate was crushed through a 100-mesh sieve, added to PEG 3350 liquid, and stirred to form a uniform suspension.

[0096] (c) The PEG 3350 suspension of enalapril maleate is spray-cooled and granulated by hot-melt spray-cooled granulation equipment.

[0097] (d) The collected gra...

Embodiment 2

[0112] The compound tablet of enalapril maleate and furosemide in this embodiment includes 5 g of enalapril maleate and 50 g of furosemide.

[0113] The compound tablet prescription of the present embodiment is as shown in table 2.

[0114] Table 2 embodiment 2 prescription list (1000)

[0115]

[0116] *: Solvent for adhesive, removed during production.

[0117] The preparation method of this embodiment is the same as that of Example 1, omitted.

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Abstract

The invention provides an enalapril maleate and furosemide compound tablet, a preparation method and application thereof. The compound tablet comprises an enalapril maleate drug-containing layer, a furosemide drug-containing layer and a blank isolation layer located in the middle, wherein the mixed materials of the enalapril maleate drug-containing layer comprise particles / powder wrapped by enalapril maleate, the mixed materials of the blank isolation layer comprise a filling agent, a disintegrating agent and a lubricating agent, the mixed materials of the furosemide medicine-containing layer comprise furosemide and an auxiliary material, the mixed material of the enalapril maleate drug-containing layer, the mixed material of the blank isolation layer and the mixed material of the furosemide drug-containing layer are sequentially mixed, and then tabletting is performed. The compound tablet disclosed by the invention adopts a preparation form of a multi-layer tablet, so that two incompatible medicinal components are compounded and separated, the compound tablet is convenient to use clinically, the stable product quality can be ensured, the content and impurities are not obviously changed after the compound tablet is placed for a long time, the stability of the product can be ensured, and the convenience of clinical use can also be ensured.

Description

technical field [0001] The invention belongs to the technical field of animal treatment, and in particular relates to a fixed-dose multilayer tablet of enalapril maleate and furosemide with stable quality, as well as a preparation method and application of the product. Background technique [0002] Along with the improvement day by day of people's living standard, family pet raising begins to enter popularization gradually. According to statistics, the number of pet dogs in China in 2019 is close to 80 million. With the increase in the number of pet dogs, the incidence of canine heart failure has been on the rise in recent years. Heart failure is a systemic blood circulation disorder accompanied by weakened myocardial contractility, reduced cardiac output, and insufficient blood supply to the arterial system. big threat. [0003] Canine heart failure is divided into acute heart failure and chronic heart failure. The etiology of acute heart failure includes sudden large-s...

Claims

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Application Information

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IPC IPC(8): A61K31/40A61K9/24A61K47/14A61K47/44A61K47/10A61P9/04A61K31/341
CPCA61K31/40A61K31/341A61K9/209A61K47/14A61K47/44A61K47/10A61P9/04A61K2300/00
Inventor 卢熀兴霍丽萍马利平
Owner 上海汉维生物医药科技有限公司