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Structured hydrogel and preparation method of hydrogel heart and valve
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A hydrogel and structuring technology, applied in prosthesis, tissue regeneration, additive processing, etc., can solve the problem of poor toughness of synthetic hydrogel
Active Publication Date: 2022-03-01
LANZHOU INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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[0004] Existing hydrogels, whether natural or synthetic, have poor toughness
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preparation example Construction
[0051] The invention provides a method for preparing a structured functional hydrogel, comprising the following steps:
[0052] Provide light-curable hydrogel ink;
[0053]According to a predetermined three-dimensional digital model, the photocurable hydrogel ink is subjected to photocurable 3D printing to obtain a printed hydrogel;
[0054] immersing the printed hydrogel in water to obtain the structured functional hydrogel;
[0055] The photocurable hydrogel ink includes the following components: monomer, photoinitiator, dyestuff and solvent;
[0056] The monomers include high-density hydrogen bond type unsaturated monomers, and the high-density hydrogen bond type unsaturated monomers include N-acryloyl semicarbazide (C 4 h 7 N 3 o 2 , NASC), N-acryloyl glycinamide (C 5 h 8 N 2 o 2 , NAGA), one or more of allyl urea and allyl urea;
[0057] The solvents include water and dimethylsulfoxide.
[0058] In the present invention, unless otherwise specified, the raw mate...
Embodiment 1
[0102] Add 15.000g of N-acryloyl semicarbazide to 35.000g of mixed solvent of dimethyl sulfoxide and deionized water (the mass ratio of dimethyl sulfoxide and deionized water is 7:3), and add after the monomer is completely dissolved 0.075g photoinitiator (LAP) (0.5% of monomermass), add 0.010g tartrazine, finally obtain uniform and transparent light-cured hydrogel ink.
[0103] The photocurable hydrogel ink is transferred to the material box of the photocurable 3D printer, the light source of the printer is 405nm, the exposure time of each layer is 20-30s, the thickness of the slice layer is 0.1mm, and the temperature of the printing environment is room temperature; The modeling software establishes the model and imports it into the 3D printing software to drive the printer to manufacture. The printed hydrogel was soaked in deionized water for 10 days to obtain a structured hydrogel, and the optical photo of the resulting structured hydrogel is as follows: figure 2 shown. ...
Embodiment 2
[0106] The difference from Example 1 is: adding 10.000 g of N-acryloyl semicarbazide and 5.000 g of acrylamide. Using a universal material testing machine, the mechanical properties of the structured hydrogel are tested, and the test results are as follows Figure 4 shown by Figure 4 It can be seen that when the strain is 335±63%, the tensile strength of the structured hydrogel reaches 2.51±0.32MPa, the elastic modulus calculated from the stress-strain curve is 2.90±0.14MPa, and the tear energy of the structured hydrogel 17.25±0.37kJ / m 2 .
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Abstract
The invention belongs to the technical field of hydrogel, and provides structured hydrogel and a preparation method of a hydrogel heart and a hydrogel valve. The preparation method comprises the following steps: providing the photocuring hydrogel ink; establishing a three-dimensional model, and carrying out photocuring 3D printing on the photocuring hydrogel ink to obtain printing hydrogel; the printing hydrogel is subjected to water immersion, and the structured functional hydrogel is obtained; the photocuring hydrogel ink comprises a high-density hydrogen bond type unsaturated monomer, a photoinitiator, a dye and a solvent, the solvent comprises water and dimethyl sulfoxide. A high-density hydrogen bond type unsaturated monomer is dissolved in a mixed solvent of dimethyl sulfoxide and water to prepare light-cured hydrogel ink, after light-cured 3D printing is conducted, obtained printing hydrogel is soaked in water, dimethyl sulfoxide in the printing hydrogel is diffused into water to be subjected to phase inversion, accordingly, hydrogen bonds in the printing hydrogel are reconstructed, and the printing hydrogel is obtained. And finally, the toughness of the structured functional hydrogel is improved.
Description
technical field [0001] The invention relates to the technical field of hydrogels, in particular to a method for preparing structured hydrogels and hydrogel hearts and valves. Background technique [0002] In recent years, new biomaterials such as polymers, ceramics, and metals have achieved rapid development and have been widely used in the medical field, greatly improving the treatment efficiency of many diseases. Although biomaterials are widely used in biomedicine, many biomaterials lack ideal functional properties (such as biomechanical matching, biocompatibility, personalized biomanufacturing, and surface-interface interactions in biological systems), making them Its application is still limited. [0003] Based on the current status and future development of biomaterials, it is necessary to control the design, synthesis, function and structural manufacture of new biomaterials, resulting in the emergence of new biomaterials based on hydrogels. Hydrogel has a hydrophili...
Claims
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