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Measuring system and measuring method

A measurement system and measurement method technology, applied in special data processing applications, complex mathematical operations, design optimization/simulation, etc., can solve problems such as low detection accuracy

Pending Publication Date: 2022-03-01
江苏济纶医工智能科技有限公司 +1
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The purpose of the present invention is to solve the problem of low detection accuracy of existing biological impedance spectroscopy methods, and provide a measurement system and measurement method

Method used

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  • Measuring system and measuring method
  • Measuring system and measuring method
  • Measuring system and measuring method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0077] [Example 1: Overall frame design of precise measurement method]

[0078] The precise measurement method of the present application and a kind of measurement system, below in conjunction with the attached figure 1 The present invention is further described.

[0079] A method for accurately measuring electrical properties during embryonic development, comprising the following steps:

[0080] Step 1, obtain the characteristic relationship between cell position and impedance: obtain the value between cell position and impedance through numerical simulation;

[0081] Using polynomials to fit and build a mathematical model between impedance and cell location;

[0082] Step 2, measuring the impedance of the cell in the sensor, and observing the coordinate position of the cell through an electron microscope;

[0083] Step 3, position correction: According to the mathematical model between the impedance and the cell position obtained in step 1 and the coordinate position of...

Embodiment 2

[0090] [Embodiment two: specific work of the numerical simulation system]

[0091] The specific work of the numerical simulation system corresponds to the work of step one.

[0092] For step 1, the mathematical model between the position of the cell in the sensor and the impedance is obtained through numerical simulation, specifically including:

[0093] S1-1, meshing the simulation area;

[0094] S1-2, randomly select any one of the positions as the central coordinate position of the embryo, and its coordinates are expressed as (x c ,y c ), frequency f is any frequency f b , and the measured impedance value is expressed as Z bc ;

[0095] Select j group for center coordinates and n group for frequency;

[0096] Then, record the impedance value matrix Z:

[0097]

[0098] Record position matrix X:

[0099]

[0100] S1-3, solve matrix A:

[0101]

[0102] The above matrix is ​​expressed by the following formula: Z=A·X

[0103] We know: A=ZX -1 (That is, it...

Embodiment 3

[0108] [Embodiment three: specific work of the position correction system]

[0109] For the method of Embodiment 1, one of the difficult problems is "how to perform position correction". Specifically, the problem is that during the actual measurement process, the embryo will change, so that the embryo will be in different positions of the sensor; and The measured impedance is different when the embryo is in different positions on the sensor, which makes it difficult to evaluate the effect.

[0110] That is, each measurement, the actual coordinate position of the embryo in the sensor (x p ,y p ) must be different, and then it is necessary to convert the impedance values ​​measured at different coordinate positions to the same coordinate position (reference position (x r ,y r ))) for comparison and analysis, and then can avoid the impact of position factors on impedance to obtain high-precision measurement results.

[0111] For this problem, proceed as follows:

[0112] T...

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Abstract

The invention relates to a measurement system and a measurement method, and the technical key points are as follows: firstly, obtaining a characteristic relation between cell position change and impedance through a simulation mode, and establishing a mathematical model between the characteristic relation and the impedance; secondly, correcting the impedance data according to the mathematical model so as to eliminate the influence of the position on the impedance and improve the measurement precision; and finally, extracting the electrical characteristics of the biological embryo through an impedance spectrum equivalent circuit automatic fitting algorithm. The measuring system and the measuring method provided by the invention are of great significance to research on drug response and cell development.

Description

technical field [0001] The invention relates to a method combining measurement and data processing, in particular to an accurate measurement method for electrical characteristics used in the embryonic development process. Background technique [0002] Since a single cell is the smallest structural and functional unit of living tissue, it is of great significance to detect the development of embryos to reveal the mysteries of life and study drug responses. [0003] However, conventional detection methods such as single-cell sequencing and gene editing technology are complex and expensive. Bioimpedance spectroscopy (Bioimpedance Spectroscopy, BIS), as a label-free, radiation-free, non-invasive new technology, has been widely used in industry, biology and medicine. [0004] The bioimpedance spectroscopy method can quantitatively determine the type, size and quantity of cells (one-dimensional information), and its application is also relatively extensive. Such as: [0005] Re...

Claims

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Application Information

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IPC IPC(8): G01N27/02G06F30/20G06F17/16
CPCG01N27/02G06F30/20G06F17/16
Inventor 姚佳烽万建芬杨璐刘凯朱芸
Owner 江苏济纶医工智能科技有限公司
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