Measuring system and measuring method
A measurement system and measurement method technology, applied in special data processing applications, complex mathematical operations, design optimization/simulation, etc., can solve problems such as low detection accuracy
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Embodiment 1
[0077] [Example 1: Overall frame design of precise measurement method]
[0078] The precise measurement method of the present application and a kind of measurement system, below in conjunction with the attached figure 1 The present invention is further described.
[0079] A method for accurately measuring electrical properties during embryonic development, comprising the following steps:
[0080] Step 1, obtain the characteristic relationship between cell position and impedance: obtain the value between cell position and impedance through numerical simulation;
[0081] Using polynomials to fit and build a mathematical model between impedance and cell location;
[0082] Step 2, measuring the impedance of the cell in the sensor, and observing the coordinate position of the cell through an electron microscope;
[0083] Step 3, position correction: According to the mathematical model between the impedance and the cell position obtained in step 1 and the coordinate position of...
Embodiment 2
[0090] [Embodiment two: specific work of the numerical simulation system]
[0091] The specific work of the numerical simulation system corresponds to the work of step one.
[0092] For step 1, the mathematical model between the position of the cell in the sensor and the impedance is obtained through numerical simulation, specifically including:
[0093] S1-1, meshing the simulation area;
[0094] S1-2, randomly select any one of the positions as the central coordinate position of the embryo, and its coordinates are expressed as (x c ,y c ), frequency f is any frequency f b , and the measured impedance value is expressed as Z bc ;
[0095] Select j group for center coordinates and n group for frequency;
[0096] Then, record the impedance value matrix Z:
[0097]
[0098] Record position matrix X:
[0099]
[0100] S1-3, solve matrix A:
[0101]
[0102] The above matrix is expressed by the following formula: Z=A·X
[0103] We know: A=ZX -1 (That is, it...
Embodiment 3
[0108] [Embodiment three: specific work of the position correction system]
[0109] For the method of Embodiment 1, one of the difficult problems is "how to perform position correction". Specifically, the problem is that during the actual measurement process, the embryo will change, so that the embryo will be in different positions of the sensor; and The measured impedance is different when the embryo is in different positions on the sensor, which makes it difficult to evaluate the effect.
[0110] That is, each measurement, the actual coordinate position of the embryo in the sensor (x p ,y p ) must be different, and then it is necessary to convert the impedance values measured at different coordinate positions to the same coordinate position (reference position (x r ,y r ))) for comparison and analysis, and then can avoid the impact of position factors on impedance to obtain high-precision measurement results.
[0111] For this problem, proceed as follows:
[0112] T...
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