Unlock instant, AI-driven research and patent intelligence for your innovation.

External preparation for skin

A skin external preparation, mass ratio technology, applied in the field of skin external preparation, can solve problems such as symptom recurrence

Active Publication Date: 2022-03-01
KAO CORP
View PDF12 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, in the treatment of atopic dermatitis, there is a problem that even if the inflammation is temporarily improved by the drug, once the external application is stopped, the symptoms will recur due to the allergen that passed through.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • External preparation for skin
  • External preparation for skin
  • External preparation for skin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～16、 comparative example 1～5

[0107] The skin external preparations shown in Tables 1 to 3 were prepared, and the "allergen permeation inhibition", "drug stability", "emulsion stability", "lubricity at the time of application" and " The good degree of spreadability at the time of application" was evaluated.

[0108] [Evaluation method of allergen permeation inhibition]

[0109] Apply 10 mg / cm on 12% by mass polyacrylamide gel (for SDS-PAGE) 2 composition and allowed to dry at room temperature for 24 hours. Next, a filter paper of φ6 mm was left still on the composition, and was wetted with 20 μL of an aqueous dye solution (Fast Green FCF, 0.02 mg / 20 mL). After standing still at 32° C. and 95% for 5 hours, the filter paper was removed, and the dried composition was removed by washing with water. Quantification of the pigment permeated through the dried composition was carried out 3 to 4 times for each composition using a densitometer, and the permeation amount of the pigment when no application was set t...

Embodiment 17

[0152] The skin external preparations of the following formulations were prepared, and the "suppression of allergen permeation", "lubricity during application", and "goodness of spreadability during application" were evaluated according to the above-mentioned method, and the results were "B", " B", "B".

[0153]

[0154]

[0155] pH = 5.1

[0156] (a1) / (a2)=0

[0157] (b1) / (b2)=0.67

[0158] (A) / (B)=2.00

[0159] (A) / (C)=6.00.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention provides an external preparation for the skin, which contains the following components (A)-(E), the mass ratio (A) / (B) of component (A) to component (B) being 0.3-2.0, the content of component (C) being 0.1-1 mass%, and the pH value at 25 DEG C being 4.0-7.0, (A) being one or more types selected from the group consisting of C14-20 aliphatic alcohols, (B) being one or more types selected from the group consisting of C14-20 aliphatic alcohols, and (E) being one or more types selected from the group consisting of C14-20 aliphatic alcohols. (B) two or more types of nonionic surfactants selected from the group consisting of polyol fatty acid ester-type nonionic surfactants; (C) one or more substances selected from the group consisting of N-acyl amino acids, N-acyl taurine and salts thereof, and phospholipids; (D) one or more substances selected from the group consisting of steroid anti-inflammatory agents, non-steroid anti-inflammatory agents, and heparinoids; and (E) water.

Description

technical field [0001] The present invention relates to an external preparation for skin. Background technique [0002] As a factor of inflammatory skin diseases, especially atopic dermatitis, it is known that a living body overreacts to an antigen (allergen), that is, an immunological abnormality and a skin barrier function abnormality. It is known that in normal skin, natural moisturizing factors such as sebum, amino acids, and urea, and interkeratinocyte lipids such as ceramides and fatty acids in the stratum corneum maintain the moisture content of the skin at a constant level, and the pH value is also maintained at a weak acidity. In contrast, in atopic dermatitis, these factors decrease in the stratum corneum, causing structural abnormalities in the stratum corneum, reducing or destroying the barrier function of the skin, and increasing the pH. Therefore, moisture transpiration from the inside of the skin increases, the moisture content of the stratum corneum also dec...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/46A61K8/73A61K31/727A61K47/18A61P37/08A61K31/164A61K31/245A61K47/14A61K8/44A61K8/63A61K47/10A61K8/37A61K31/573A61K47/20A61K47/24A61Q19/00A61P17/04A61P29/00A61P43/00A61K8/34A61K8/55A61K31/56A61P17/00A61K8/41
CPCA61K8/46A61K8/73A61K9/0014A61K31/727A61K47/18A61P37/08A61K31/164A61K31/245A61K47/14A61K8/44A61K8/63A61K47/10A61K8/37A61K31/573A61K47/20A61K47/24A61Q19/00A61P17/04A61P29/00A61P43/00A61K8/34A61K8/55A61K31/56A61P17/00A61K8/41A61K47/26A61K47/183A61K47/12A61K47/44A61K8/375A61K8/4973A61K8/466A61K8/922A61K8/4993A61K8/553A61K8/70A61Q17/00A61K8/342A61K8/735A61K45/06A61K9/107A61K2300/00A61K9/7015
Inventor 衣笠仁教松冈惠美渡边学
Owner KAO CORP
Features
  • R&D
  • Intellectual Property
  • Life Sciences
  • Materials
  • Tech Scout
Why Patsnap Eureka
  • Unparalleled Data Quality
  • Higher Quality Content
  • 60% Fewer Hallucinations
Social media
Patsnap Eureka Blog
Learn More

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2025 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com