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Statistics-based good and bad fructus forsythiae medicine classification method

A technology of forsythia, good and bad, applied in the field of classification of good and bad medicines based on statistics, can solve problems such as insufficient and unreasonable

Pending Publication Date: 2022-03-04
SHIMADZU (CHINA) CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This shows that it is not enough and unreasonable to only use the two indexes of forsythin and forsythiaside A as the indexes for the content determination of forsythia

Method used

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  • Statistics-based good and bad fructus forsythiae medicine classification method
  • Statistics-based good and bad fructus forsythiae medicine classification method
  • Statistics-based good and bad fructus forsythiae medicine classification method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Example 1 Material Analysis of Forsya Samples of Greening and Normal Picking

[0049] Sample Preparation

[0050] After the forsythia powder is weighed into the top and space, the weight per bottle is about 2.15g. Put into the AOC-6000PLUS GCMS-TQ8040 with the SPME module, such as figure 1 Indicated.

[0051] Analytical conditions

[0052] SPME condition

[0053] SPME probe Shimadzu Smart SpMearrow 1.10mm: DVB / C-WR / PDMS Aging temperature 240℃ Aging time (before extraction) 0 Balance temperature 40℃ Balance time 5min Extraction time 8min Inlet temperature 250℃ Destructive time 1min Aging time (after extraction) 10min

[0054] GCMS condition

[0055] Column Inertcap Pure-Wax, 30M × 0.25mm × 0.25μm Column temperature program 50 ° C (5min) _10 ° C / min_250 ° C (10min) Flow control method pressure Carrier pressure 835kpa Injection Diversion injection Diversion ratio 40∶1 Ion sourc...

Embodiment 2

[0057] Example 2 PCA Analysis of Forsteed Samples of Forsteed Samples and Normal Pick

[0058] The use of SignPOST software to grab the blue rose sample (Pick in June, 20 cases in July) and 56 normal roll-up (20 cases in August, Picking 20 cases in September, 19 cases in October) Perform the main component analysis (PCA) treatment. The specific analysis processing conditions are processed in the following table.

[0059] PCA analysis processing conditions

[0060]

[0061]

[0062] The retention time of A and B is a range of 11.5-12.5 min as the range established by the PCA model, and PCA analysis is performed directly within the time range in the spectrum and its debris. image 3 Indicated. Through the PCA analysis, 32 cases of grasp the greening and 56 patients can be directly collected into two categories. This method is simple and fast, and the future can develop into a statistical classification database directly to screen and discriminate.

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Abstract

The invention relates to a method for classifying good and bad forsythia suspensa medicines based on statistics. Experimental research is carried out on good and bad forsythia suspensa samples in different picking periods by using a gas chromatograph-mass spectrometer with an SPME module. According to experimental results, two different substances having extremely high correlation with the quality of the fructus forsythiae are found, and the relative content of the two different substances can be used as an identification basis for effectively distinguishing the quality of the fructus forsythiae. On this basis, by introducing PCA analysis, the good and bad forsythia suspense can be directly subjected to statistical classification, and the method is simple and rapid, and can be developed into a statistical classification database to directly screen and discriminate the good and bad forsythia suspense in the future.

Description

Technical field [0001] The present invention relates to a method for detecting medicine, in particular to a drug-based statistical classification forsythia merits. Background technique [0002] Forsythia (Forsythiae Fructus), also known as fall Alice, yellow stripe, yellow flower chain. Forsythia fruit from flowering to maturation stages: incubation period bud, flowering stage, embryo formation, fruit enlargement, generation of seeds, fruit ripening, seed maturity, cracking of the fruit, seed dispersal stage, fruit shell off period. When the first fruits harvest autumn fruit is still green belt, remove impurities, steamed, dried, Xi said, "Alice Green." Ripe fruit when harvested, dried to remove impurities, often called "old Alice." Lignans, flavonoids, volatile components, ethylbenzene class, ethylcyclohexyl alcohol, triterpenoid-containing compounds and coumarins. There betulinic acid, phillyrin, arctiin, Podocarpus aliphatic glycosides, pinoresinol, forsythia glycosides C, D, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02G01N30/06G01N30/86G06K9/62
CPCG01N30/02G01N30/06G01N30/8696G01N2030/062G06F18/2135G06F18/241
Inventor 汤博崇刘永利李晓东雷蓉袁浩曹磊
Owner SHIMADZU (CHINA) CO LTD