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Bionic-based high-purity hypochlorous acid hydrogel and preparation method thereof

A technology of hypochlorous acid water and hypochlorous acid, which is applied in the directions of hypochlorous acid, chlorine active ingredients, skin diseases, etc., can solve problems such as less hypochlorous acid gel, and achieve stable effective chlorine content, simple preparation components, and method. easy effect

Pending Publication Date: 2022-03-11
杭州易沃科信息科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] There are few reports on hypochlorous acid gel used for wound treatment

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The present embodiment provides a bionic-based high-purity hypochlorous acid hydrogel, according to the following method:

[0026] The first step is to prepare bionic-based high-purity hypochlorous acid water;

[0027] The preparation method of bionic high-purity hypochlorous acid disinfection water, the configuration amount m of the immobilized methyl rhenium trioxide catalyst is 800mg, the mass concentration of hydrogen peroxide is 3%, and the mass concentration of sodium chloride is 6%. The mass concentration of hydrochloric acid is 0.3%. The mixing ratio of purified water: hydrogen peroxide: sodium chloride: hydrochloric acid is 200:0.5:1:0.15. The catalytic reaction was carried out at room temperature. After the reaction, the content of hypochlorous acid was measured by DPD spectrophotometry, and the content of hypochlorous acid reached 205.6mg / L; the pH value was measured with a portable pH meter, and the pH value was 5.78.

[0028] In the second step, high-puri...

Embodiment 2

[0031] This embodiment provides a bionic-based high-purity hypochlorous acid hydrogel, the preparation method of which is the same as that of Embodiment 1, wherein the configuration amount m of the immobilized methyl rhenium trioxide catalyst is 1000 mg, and the mass of hydrogen peroxide is used The concentration is 3%, the mass concentration of sodium chloride is 6%, and the mass concentration of hydrochloric acid is 0.3%. The mixing ratio of purified water: hydrogen peroxide: sodium chloride: hydrochloric acid is 600:0.5:1:0.1. The catalytic reaction was carried out at room temperature. After the reaction, the content of hypochlorous acid was measured by DPD spectrophotometry, and the content of hypochlorous acid reached 59.2mg / L; the pH value was measured with a portable pH meter, and the pH value was 5.98.

[0032] Hypochlorous acid hydrogel, in terms of mass percentage, the proportion of each raw material in its preparation components is: hypochlorous acid water 96.8%, al...

Embodiment 3

[0034] This embodiment provides a bionic-based high-purity hypochlorous acid hydrogel, the preparation method of which is the same as that of Embodiment 1, wherein the configuration amount m of the immobilized methyl rhenium trioxide catalyst is 1000 mg, and the mass of hydrogen peroxide is used The concentration is 3%, the mass concentration of sodium chloride is 6%, and the mass concentration of hydrochloric acid is 0.3%. The mixing ratio of purified water: hydrogen peroxide: sodium chloride: hydrochloric acid is 3000:0.5:1:0.1. The catalytic reaction was carried out at room temperature. After the reaction, the content of hypochlorous acid was measured by DPD spectrophotometry, and the content of hypochlorous acid reached 16.9 mg / L; the pH value was measured with a portable pH meter, and the pH value was 6.04.

[0035] Hypochlorous acid hydrogel, in terms of mass percentage, the proportion of each raw material in its preparation components is: hypochlorous acid water 98%, al...

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Abstract

The invention discloses high-purity hypochlorous acid hydrogel based on bionics and a preparation method, and belongs to the technical field of biomedical materials. According to the method, a generation mode of hypochlorous acid in human neutrophil is imitated, hydrogen peroxide, sodium chloride and hydrochloric acid with a certain concentration are used as raw materials, methylrhenium trioxide is used as a catalyst to prepare a high-purity hypochlorous acid solution, and meanwhile, the methylrhenium trioxide catalyst is recycled by adopting a reverse osmosis filter membrane filtration method. The hypochlorous acid hydrogel can be prepared by taking the high-purity hypochlorous acid water prepared by the method as a raw material, adding a gelling agent and taking alkaline electrolyzed water as a pH (Potential of Hydrogen) regulator. The hypochlorous acid water obtained by the invention is higher in purity and convenient to prepare, and the prepared hydrogel has an excellent antibacterial effect.

Description

technical field [0001] The invention discloses a method for preparing bionic high-purity hypochlorous acid water and its gel, belonging to the technical field of biomedical materials. Background technique [0002] The human immune system can resist the invasion of external pathogens, largely because the immune system produces highly active chemical substances, such as reactive oxygen species (ROS), to produce an effective and rapid bactericidal response. Mitochondrial membrane-bound reduced coenzyme II (hereinafter referred to as NADPH) is the main enzyme for ROS production. During neutrophil activation, respiration produces hydrogen peroxide (H 2 o 2 ), while the activated myeloperoxidase (MPO) in Cl - and H + In the presence of H 2 o 2 Converted to hypochlorous acid (HOCl). [0003] Quantitative analysis results show that within 2 hours of incubation, 100,000 activated neutrophils can produce about 2×10 -7 mol of hypochlorous acid. In actual production, hypochloro...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K33/20A61P17/02A61P31/04A61P31/02C01B11/04
CPCA61K9/06A61K33/20A61P17/02A61P31/04A61P31/02C01B11/04Y02P20/584
Inventor 李世通陈仲敏叶章颖
Owner 杭州易沃科信息科技有限公司
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