3 results about "Methylrhenium trioxide" patented technology

The invention relates to the technical field of organic synthesis, and discloses a preparation method of trimethylbenzoquinone, which comprises the following steps: mixing a reaction solution containing unsym-trimethylbenzene and an organic solvent with a catalyst, and adding an oxidizing agent to carry out oxidation reaction to obtain trimethylbenzoquinone, wherein the catalyst comprises a pyridine compound and methylrhenium trioxide. According to the method, the unsym-trimethylbenzene is adopted as a raw material, the methylrhenium trioxide and the pyridine compound are adopted as catalysts, the trimethylbenzoquinone is prepared through oxidation of the oxidizing agent, the product yield is high, and the consumption of the oxidizing agent is low.

The invention discloses a synthesis method of a viloxazine metabolite 5-hydroxyl viloxazine hydrochloride, which comprises the following steps: (1) dissolving viloxazine hydrochloride, namely a raw material I, in a solvent, and reacting with Boc anhydride under an alkaline condition to obtain an intermediate II; (2) dissolving the intermediate II in a solvent, and performing oxidation reaction with an oxidant in the presence of a metal catalyst to obtain an intermediate III; the metal catalyst is methylrhenium trioxide or ruthenium trichloride; the oxidizing agent is hydrogen peroxide or urea peroxide; and (3) dissolving the intermediate III in a solvent, and reacting under an acidic condition to obtain a compound IV, namely the viloxazine metabolite 5-hydroxyl viloxazine hydrochloride. According to the method, synthesis of the 5-hydroxyl viloxazine hydrochloride is realized for the first time, the viloxazine hydrochloride is taken as a raw material, a brand new method for synthesizing the 5-hydroxyl viloxazine hydrochloride is designed, and the purity of the product can reach 98% or above.

The application belongs to the technical field of fine chemical industry, and particularly relates to a continuous flow synthesis method and device of diene diepoxide. The method comprises the following steps: mixing an organic phase containing a diene compound, a catalyst and a pyridine-acetic acid ligand, and an aqueous phase containing hydrogen peroxide and a specific buffer system through a micro-mixer to form a water-in-oil micro-dispersion system; making the micro-dispersion system enter a micro-reactor to perform an epoxidation reaction; then performing cooling treatment on the reaction liquid; removing the aqueous phase through a membrane separator; and obtaining the diene diepoxide through post-treatment. By introducing the buffer system, the pH of the reaction system is stabilized at 10.5-12.0, the decomposition of hydrogen peroxide and the deactivation of methyltrioxorhenium are effectively inhibited; in combination with the continuous flow technology, the reaction process is accurately controlled and intrinsically safe, and the reaction time is significantly shortened; and the conversion rate of the diene compound and the yield of the target epoxide are both significantly improved.