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A kind of sodium tantalate film layer with biological activity and antibacterial property and preparation method thereof

A bioactive sodium tantalate technology, which is applied in coating, tissue regeneration, metal material coating technology, etc., can solve the problems of poor bioactivity of metal tantalum, weak ability of new bone formation, and lack of antibacterial properties. Low cost, promoting proliferation, improving biological activity and antibacterial effect

Active Publication Date: 2022-07-12
SHAANXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Like most medical metals, pure metal tantalum has poor bioactivity, weak ability to promote new bone formation and no antibacterial properties, which limits its clinical application
At present, there is no report on the co-introduction of functional elements Ca and Cu into the surface of tantalum by hydrothermal method combined with molten salt method and used as a medical implant material.

Method used

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  • A kind of sodium tantalate film layer with biological activity and antibacterial property and preparation method thereof
  • A kind of sodium tantalate film layer with biological activity and antibacterial property and preparation method thereof
  • A kind of sodium tantalate film layer with biological activity and antibacterial property and preparation method thereof

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preparation example Construction

[0037] The preparation process of the above-mentioned biomedical metal material comprises the following steps:

[0038]Step 1: Put the tantalum sheet and the NaOH hydrothermal solution together into the hydrothermal reactor for hydrothermal reaction, that is, a uniform NaTaO is formed on the surface of the tantalum 3 film layer;

[0039] Step 2: Cover the NaTaO 3 The tantalum sheet of the film is placed in CaCl 2 The molten salt treatment in the powder forms a Ca-doped surface on the tantalum surface. 2+ NaTaO 3 film layer.

[0040] Step 3: Doping with Ca 2+ NaTaO 3 Coated Tantalum and CuCl 2 The hydrothermal solution is put into the hydrothermal reaction kettle together for hydrothermal reaction, that is, Ca-doped Ca is formed on the surface of tantalum. 2+ and Cu 2+ NaTaO 3 film layer.

[0041] CuCl in step 3 2 The concentration of the solution is 0.0001 to 0.1 mol / L.

[0042] The sequence of the reaction steps in Steps 2 and 3 can be replaced, and Cu is doped f...

Embodiment 1

[0046] A biologically active and antibacterial (sodium tantalate) NaTaO 3 Membrane layer and preparation method thereof, raw materials include metal tantalum sheet, NaOH, anhydrous CaCl 2 and CuCl 2 ;

[0047] The concentration of above-mentioned NaOH is 2mol / L;

[0048] The preparation process of the above-mentioned biomedical metal material comprises the following steps:

[0049] Step 1: Put the tantalum sheet and the NaOH hydrothermal solution into the hydrothermal reaction kettle together to carry out the hydrothermal reaction. The temperature of the hydrothermal reaction is 220° C. and the time is 24 hours. Among them, when the hydrothermal solution was injected into the hydrothermal reactor, the filling degree of the solution was 30%, and then the Ca-doped 2+ The tantalum sample was immersed in a hydrothermal solution for a hydrothermal reaction, that is, a uniform NaTaO was formed on the surface of the tantalum 3 film layer;

[0050] Step 2: Cover the NaTaO 3 The...

Embodiment 2

[0053] A biologically active and antibacterial NaTaO 3 Membrane layer and preparation method thereof, raw materials include metal tantalum sheet, NaOH, anhydrous CaCl 2 and CuCl 2 ;

[0054] The concentration of above-mentioned NaOH is 2mol / L;

[0055] The preparation process of the above-mentioned biomedical metal material comprises the following steps:

[0056] Step 1: Put the tantalum sheet and the NaOH hydrothermal solution into the hydrothermal reaction kettle together to carry out the hydrothermal reaction. The temperature of the hydrothermal reaction is 220° C. and the time is 24 hours. Among them, when the hydrothermal solution was injected into the hydrothermal reactor, the filling degree of the solution was 30%, and then the Ca-doped 2+ The tantalum sample was immersed in a hydrothermal solution for a hydrothermal reaction, that is, a uniform NaTaO was formed on the surface of the tantalum 3 film layer;

[0057] Step 2: Cover the NaTaO 3 The tantalum sheet of ...

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Abstract

The present invention provides a surface-modified biometal material with osteopromoting ability and antibacterial ability. The surface modification technology prepares a bioactive film layer co-doped with functional elements calcium and copper on the surface of pure tantalum through the synergistic effect of hydrothermal-molten salt-hydrothermal method (or hydrothermal-hydrothermal-molten salt method). First, a uniform sodium tantalate film was prepared on the surface of metal tantalum by the hydrothermal method, and then the Ca 2+ Doped on the sodium tantalate film, and finally doped with Ca 2+ Tantalum of sodium tantalate film is doped with Cu by secondary hydrothermal 2+ , so that a Ca-Cu co-doped film layer with biological activity and antibacterial property was formed on the surface of pure tantalum. The film layer containing calcium and copper prepared by this method is evenly distributed on the surface of tantalum, which is beneficial to promote cell differentiation, improve cell activity, and has certain antibacterial properties, thereby improving the osteopromoting and antibacterial properties of tantalum metal. The field of materials shows a good application prospect.

Description

technical field [0001] The invention belongs to the technical field of surface modification of metal materials, and in particular relates to a sodium tantalate film layer with biological activity and antibacterial properties and a preparation method thereof. Background technique [0002] Due to the frequent occurrence of car accidents, conflicts and disasters, there will always be damage or severe damage to the hard tissues of the body such as teeth and bones. Due to its superior mechanical properties, corrosion resistance, safety and non-toxicity, medical metal tantalum (Ta) is widely used in hip replacement, knee joint repair and other fields. Like most medical metals, pure metal tantalum has poor biological activity, weak ability to promote new bone formation and no antibacterial properties, so its clinical application is limited. In addition, in the hard tissue implantation surgery, postoperative infection is also one of the problems to be solved urgently. These are th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/54A61L27/04A61L27/30C23C22/64C23C22/83
CPCA61L27/54A61L27/047A61L27/306C23C22/64C23C22/83A61L2430/02A61L2300/102A61L2300/404A61L2300/412
Inventor 王翠翠张意茹蔡安琦张于浩刘轶凡陈倩宋颖轩殷海荣
Owner SHAANXI UNIV OF SCI & TECH