Pharmaceutical composition containing 6-diazo-5-oxo-L-n-leucine and used for treating inflammatory skin diseases
An inflammatory skin disease, norleucine technology, applied in the field of pharmaceutical compositions containing 6-diazo-5-oxo-L-norleucine for the treatment of inflammatory skin diseases, can solve the problem of unrecognized and other problems to achieve the effect of inhibiting secretion, treating allergic dermatitis and psoriasis, and inhibiting overgrowth
Pending Publication Date: 2022-03-11
NATUREBLUE CO LTD
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Problems solved by technology
[0005] In addition, steroid immunomodulator (Elidel, pimecrolimus) cream and protopic (Protopic, tacrolimus, FK506) ointment have also been developed, and there are no side effects that appear in existing steroid ointments when applied for a long time, and they are also used on the face On sensitive skin such as skin or neck, someone recently raised the risk of cancer induced by cassinoline low doses. Patients under the age of 16 only accept the use of low concentrations, and children under the age of 2 do not even approve the use of low concentrations.
[0006] As other allergic treatment agents, antihistamines are also used, and in severe cases, short-term adrenal corticosteroid drug treatment, external solvent application, skin ultraviolet treatment or interferon treatment, etc., but when drug administration is stopped, Inflammatory skin disease will relapse and is a refractory disease
Method used
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Embodiment
[0087] The proliferation of cells and the secretion of chemokines require the production of macromolecules, such as proteins, lipids, and nucleic acids, which consume large amounts of energy. Glucose and glutamine are carbon molecules that are the basic energy sources of mammalian cells. In light of this, glutamine is thought to be key to inflammatory diseases, and it was intended to be used to demonstrate inhibition of atopic dermatitis in animals.
[0088] DON is an antagonist of glutamine, interfering with glutamine metabolism. Since DON has such a hindrance to glutamine metabolism, the following experiments were conducted to confirm that it can achieve the therapeutic effect of skin inflammation without suppressing immune cells.
[0089] 1. Inhibit the proliferation of epithelial cells
[0090] Such as figure 1 and figure 2 As shown, it was confirmed that in mice induced with TPA and oxazoline, the thickness of the epithelium was confirmed after DON was used to treat ...
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The present invention relates to a pharmaceutical composition comprising 6-diazo-5-oxo-L-norleucine or a pharmaceutically acceptable salt thereof for use in the treatment or prevention of inflammatory skin diseases, including inflammatory skin diseases and psoriasis.
Description
technical field [0001] The invention relates to a pharmaceutical composition for treating or preventing inflammatory skin diseases (including atopic dermatitis and psoriasis), which contains 6-diazo-5-oxo-L-norleucine or its pharmaceutical composition acceptable salt. Background technique [0002] Recently, inflammatory skin diseases that have emerged as social problems include atopic dermatitis and psoriasis, which may lead to increased scratching accompanied by itching, thereby further exacerbating symptoms. [0003] In order to treat these skin diseases, the treatment mainly uses steroids and calmodulin inhibitors that suppress the activity of immune cells. For example, Korean Patent Registration No. 10-0647857 introduces a dermatological treatment composition including steroids and dermatitis treatment, while International Patent No. WO 2017-207819 introduces a dermatological treatment composition including a calcium inhibitor. [0004] However, the commonly used stero...
Claims
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Login to View More IPC IPC(8): A61K31/655A61K9/00A61P17/00A61P17/06A61P29/00
CPCA61P17/00A61P17/06A61P29/00A61K9/0014A61K9/0019A61K31/655
Inventor 金敏清安宰亨
Owner NATUREBLUE CO LTD