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Photoacoustic sensor compatible with OCT (Optical Coherence Tomography)

A photoacoustic sensor and sensor technology, which is used in eye testing equipment, medical science, diagnosis, etc., can solve the problems of large overall system volume, low system detection sensitivity, and difficult application of human eyes, etc., and achieves high detection sensitivity, high-resolution effects

Pending Publication Date: 2022-03-22
BEIJING INSTITUTE OF TECHNOLOGYGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are also a few scholars who have clearly imaged the eyes of animals through photoacoustic imaging systems, but the methods used are to use large ultrasonic transducers and configure water tanks to collect photoacoustic signals.
Although the image of the inside of the eyeball can also be obtained, such a system has the following disadvantages: first, the overall system is bulky; second, the detection sensitivity of the system is not high; third, due to the particularity of the human eye, it is difficult to apply to clinical

Method used

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  • Photoacoustic sensor compatible with OCT (Optical Coherence Tomography)
  • Photoacoustic sensor compatible with OCT (Optical Coherence Tomography)
  • Photoacoustic sensor compatible with OCT (Optical Coherence Tomography)

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Such as figure 1 As shown, a photoacoustic sensor compatible with OCT includes: probe shell 1, upper electrode 2, curved self-focusing piezoelectric film 3, lower electrode 4, acoustic matching layer 5, eye drop coupling agent 6, eyeball 7, light Signal 8.

[0037] The probe shell 1 has a through hole at the top, the size of the through hole is 2mm, it is made of PDMS material, and is located outside the upper electrode 2, the curved self-focusing piezoelectric film 3, the lower electrode 4, and the acoustic matching layer 5; the upper electrode 2, The centers of the curved self-focusing piezoelectric film 3, the lower electrode 4, and the acoustic matching layer 5 are all provided with a 2 mm through hole; the upper electrode 2 is located between the probe shell 1 and the curved self-focusing piezoelectric film 3, and the thickness is 1 μm; the curved self-focusing The focusing piezoelectric film 3 has a thickness of 100 μm, is a curved surface with a radius of curvat...

Embodiment 2

[0040] On the basis of Example 1, only the probe shell 1, upper electrode 2, curved arc piezoelectric film 3, lower electrode 4, and acoustic matching layer 5 are changed from curved arcs to flat fields to achieve the maximum transducer energy. The range detects the information on both sides of the fundus, and the rest of the structures are the same as in Embodiment 1, such as figure 2 .

[0041] The above design structure was simulated to obtain an OCT-compatible photoacoustic sensor with a central operating frequency of about 30MHz. Such as Figure 6 As shown, the OCT-compatible photoacoustic sensor can detect the largest range on both sides of the fundus center.

Embodiment 3

[0043] On the basis of Example 1, only the probe shell 1, the upper electrode 2, the curved arc piezoelectric film 3, the lower electrode 4, and the acoustic matching layer 5 are changed from a curved arc to an inclined flat field, and the flat field inclined piezoelectric film The inclination angle of film 3 is 5 °, and all the other structures are the same as embodiment 1, as image 3 .

[0044] The above design structure was simulated to obtain an OCT-compatible photoacoustic sensor with a central operating frequency of about 30MHz. Such as Figure 7 As shown, the OCT-compatible photoacoustic sensor can detect a large area of ​​the fundus.

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Abstract

The invention relates to a photoacoustic sensor compatible with OCT, and belongs to the technical field of photoacoustic imaging and the technical field of ultrasonic sensors. The sensor is small in size and flexible, can be directly attached to the surface of an eye like wearing a contact lens after eye drops are dropwise added in advance, and can meet clinical application requirements. Moreover, the sensor is provided with a central through hole, and does not cover the pupil during use, so that the sensor can be compatible with ophthalmology OCT. Meanwhile, pulsed light of a photoacoustic imaging system can be transmitted into the eyeball through the central through hole of the sensor to excite an object to be detected at the fundus to generate a photoacoustic signal (ultrasonic wave), the ultrasonic wave is transmitted to the ocular surface from the fundus, and as the eye drops are dropwise added in advance, the ultrasonic wave can be fully coupled and transmitted to the photoacoustic sensor attached to the surface of the eye; the sound waves are converted into electric signals after being collected by the sensor. Under the condition that the OCT imaging system is compatible, the photoacoustic image can be conveniently obtained, and the method is a new technology with great clinical application potential.

Description

technical field [0001] The invention relates to an OCT-compatible photoacoustic sensor, which belongs to the technical fields of photoacoustic imaging and ultrasonic sensors. Background technique [0002] Photoacoustic imaging is a new type of biomedical imaging technology. The photoacoustic imaging technology combines the advantages of optical resolution and acoustic penetration depth. Compared with traditional pure optical imaging technologies, such as optical coherence tomography (OCT), it avoids the penetration depth caused by light scattering. It has a small limit and has a deeper detection depth; compared with traditional ultrasonic imaging technology, the contrast of photoacoustic imaging technology comes from the difference in the light absorption of the object to be measured, which avoids the difference in the acoustic impedance of the target object. The resulting imaging contrast is not high, and the lateral resolution of photoacoustic imaging depends on the optic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B3/12A61B3/125A61B3/14
CPCA61B3/102A61B3/1233A61B3/125A61B3/14
Inventor 张金英赵冬冬史亦凡李德芳
Owner BEIJING INSTITUTE OF TECHNOLOGYGY
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