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High-fat meal formula for fat tolerance test

A technology of tolerance test and fat, which is applied in the field of high-fat meal tolerance test, can solve the problems of long taking time, authenticity of cover test, and no uniform standard of total calories, etc., and achieve the effect of stable test

Pending Publication Date: 2022-03-25
河北省人民医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In the process of postprandial hyperlipidemia examination, there is no uniform standard for the total calorie intake of the subjects, resulting in no accurate reference value for postprandial test results, although some studies have shown that postprandial blood lipid levels can be predicted Metabolic diseases, but at home and abroad, the results are unstable due to unclear calorie intake, and there is no established postprandial blood lipid level index for judging the risk of metabolic diseases, which loses the significance of postprandial observation of the subject's tolerance to lipids;
[0006] The high-fat meal used in the inventor's historical experiments has a calorie of up to 1500kcal, and the high-fat meal with 1500kcal has a large amount, and the patient has difficulty in oral administration, taking a long time, and the high calorie causes the patient's intolerance, nausea, and even vomiting and diarrhea. It leads to changes in the patient's absorption capacity, and makes a large number of patients participating in the trial drop out of the trial, which leads to the inability to continue the trial, and the 1500kca calorie is too large. There is a big difference in test performance between fatter and thinner patients. The authenticity of the test, after a period of time after using a 1500kcal high-fat meal, the patient cannot fully digest, has excess energy, and the blood lipid level in the body cannot be restored

Method used

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  • High-fat meal formula for fat tolerance test

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] The first group was given 1500kcal of heat, and a total of 100 volunteers were recruited, 21 of whom experienced nausea, vomiting and other gastrointestinal discomfort reactions after eating a high-fat meal (15 of the 21 were less than 60kg in weight), and another 5 successfully passed the test. After eating a high-fat meal within 10 minutes, but diarrhea symptoms occurred at different times after the meal, these 26 subjects were unable to complete the follow-up blood collection due to the above discomfort symptoms, and quit the test midway, and finally a total of 74 subjects completed all oral fat Endurance test. The results are as follows

[0019] Table 1: 1500kcal test results

[0020]

[0021]

[0022] The second group subsequently recruited 100 volunteers to carry out the high-fat meal formula of the fat tolerance test of the present invention. All the subjects finished eating within 10 minutes, and 2 cases complained of mild nausea without dizziness and vom...

Embodiment 2

[0031] Subsequent comparisons of triglyceride levels at different time points before the test and after taking a high-fat meal showed that after the administration of 1500kcal calories, the serum triglyceride level of the test population increased significantly, and was still significantly higher than the fasting level 10 hours after the meal. And when the high-fat meal formula of the fat tolerance test of the present invention is given after the improvement, the change of serum triglyceride is relatively gentle, and it is basically reduced to the fasting level 8 hours after the meal, which suggests that a single administration of 1500kcal calories is too high, and the blood lipid load is overloaded. , the follow-up blood lipid value is less stable, and given the high-fat meal formula of the fat tolerance test of the present invention, the follow-up data is more stable.

[0032]

Embodiment 3

[0034] All subjects are grouped according to body weight, and it is found that giving 15000kcal heat is too large for the low body weight group load, causing postprandial blood lipids to significantly increase (Table 5), after the high-fat meal formula (Table 6) of the fat tolerance test of the present invention, The subjects in the low body weight group have good tolerance and stable postprandial reaction, suggesting that the high-fat meal total calories of the high-fat meal formula of the fat tolerance test of the present invention have a wider application range

[0035] Table 4

[0036]

[0037] table 5

[0038]

[0039] *: P<0.05; **: P<0.01.

[0040] It can be concluded from the above table that the high-fat meal prepared by the present invention can standardize the total calorie intake of the subjects, and further predict metabolic diseases by screening groups with reduced lipid tolerance, making up for the existing high-fat diet. Screening of patients with hyper...

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Abstract

The invention discloses a high-fat meal formula for a fat tolerance test, and relates to the field of high-fat meal tolerance tests. The invention relates to a high-fat meal formula for a fat tolerance test, which is characterized in that each part of high-fat meal for the fat tolerance test is 200ml in total and comprises 9.3 g of saturated fatty acid, 18.6 g of monounsaturated fatty acid, 18.6 g of polyunsaturated fatty acid, 43.8 g of protein, 26.2 g of carbohydrate completely provided by glucose and 1.8 g of sodium; the invention provides the high-fat meal formula for the fat tolerance test, the total calorie is less than half of the total calorie in the historical test, and the blood fat reaction of the testee after the high-fat meal load is observed, so that the defect that only the static blood fat value level of the testee in the empty stomach state is checked in the prior art is overcome.

Description

technical field [0001] The invention relates to the field of high-fat meal tolerance test, in particular to a high-fat meal formula for fat tolerance test. Background technique [0002] Hyperlipidemia refers to excessive blood lipid levels, which can directly cause some diseases that seriously endanger human health, such as hypertension, diabetes, atherosclerosis, coronary heart disease, pancreatitis, etc., and are important risk factors for these metabolic diseases. Early intervention and treatment of patients with hyperlipidemia can reduce the occurrence and development of the above metabolic diseases. In the past, it was considered that the plasma total cholesterol concentration> 5.17mmol / L (200mg / dl) could be defined as hypercholesterolemia, and the plasma triacylglycerol concentration> 2.3mmol / L (200mg / dl) was regarded as hypertriglyceremia; Due to factors such as different populations and different test methods, the diagnostic criteria for postprandial hyperlipi...

Claims

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Application Information

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IPC IPC(8): A61K49/00
CPCA61K49/0004
Inventor 宋光耀侯晓宇宋桉王超任路平
Owner 河北省人民医院
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