Preparation process and device of selenized chitosan oligosaccharide and application of selenized chitosan oligosaccharide

A kind of chitosan oligosaccharide and preparation technology, which can be used in medical preparations containing active ingredients, mixers with rotating stirring devices, chemical/physical/physicochemical processes using energy, etc., and can solve the problem of product yield decline , unfavorable reactions, full of workshops and other problems, to achieve the effect of preventing the temperature from rising too high, fully dialysis concentration, and good cell repair

Active Publication Date: 2022-03-25
ZHONGHEFA BEIJING BIOLOGICAL SCI & TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation process of the selenized chitosan oligosaccharide disclosed by this invention has simple steps, strong operability, and high selenium content in the product, but in the process of realizing its industrial production, the ultrasonic treatment in the second step will often reduce the temperature of the reaction solution increase, and when the temperature of sodium selenite is too high, selenous acid will decompose, which is unfavorable for the carrying out of the reaction, and the temperature increase will cause the further hydrolysis of oligomeric amino polysaccharides, thereby reducing the yield of the product. T

Method used

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  • Preparation process and device of selenized chitosan oligosaccharide and application of selenized chitosan oligosaccharide
  • Preparation process and device of selenized chitosan oligosaccharide and application of selenized chitosan oligosaccharide
  • Preparation process and device of selenized chitosan oligosaccharide and application of selenized chitosan oligosaccharide

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Embodiment 1

[0049] Embodiment 1 discloses a kind of preparation technology of selenized chitosan oligosaccharide, comprising the steps:

[0050] 1) Put the chitosan oligosaccharide into the stirring mixing tank according to a certain proportion and stir and dissolve it in the aqueous acetic acid solution to obtain the chitosan oligosaccharide solution; wherein the mass ratio of the chitosan oligosaccharide and the aqueous acetic acid solution is 2:15, and the acetic acid The pH of the aqueous solution is 4.

[0051] 2) transfer the chitosan oligosaccharide solution to a temperature-controlled ultrasonic treatment tank, then add a certain amount of sodium selenite, and then carry out ultrasonic treatment under the action of catalyst nickel, so that the chitosan oligosaccharide solution and selenous acid Sodium fully reacted; the mass ratio of sodium selenite to chitosan oligosaccharide solution was 3:16, ultrasonic treatment was performed for 35 minutes, and the temperature during ultrason...

Embodiment 2

[0056] Embodiment 2 discloses a kind of preparation technology of selenized chitosan oligosaccharide, comprising the steps:

[0057] 1) Put the chitosan oligosaccharide into the stirring mixing tank according to a certain proportion and stir and dissolve it in the aqueous acetic acid solution to obtain the chitosan oligosaccharide solution; wherein the mass ratio of the chitosan oligosaccharide and the aqueous acetic acid solution is 1:7, and the acetic acid The pH of the aqueous solution is 3.8.

[0058] 2) transfer the chitosan oligosaccharide solution to a temperature-controlled ultrasonic treatment tank, then add a certain amount of sodium selenite, and then carry out ultrasonic treatment under the action of catalyst nickel, so that the chitosan oligosaccharide solution and selenous acid The sodium fully reacted; the mass ratio of sodium selenite to chitosan oligosaccharide solution was 1:5, ultrasonic treatment was performed for 40 minutes, and the temperature during ultr...

Embodiment 3

[0064] This embodiment 3 discloses a device used in the preparation process of selenized chitosan oligosaccharides in embodiment 1 and embodiment 2, with reference to the attached figure 2 And attached image 3 , the main part of the device includes a frame 100, a stirring and mixing tank 200, a temperature-controlled ultrasonic treatment tank 300, a centrifugal dialysis concentration device 400 and a control box 500, a stirring and mixing tank 200, a temperature-controlled ultrasonic treatment tank 300, a centrifugal dialysis concentration The device 400 is fixedly arranged on the upper end of the frame 100 in sequence from left to right.

[0065] Reference attached Figure 4 , the upper end of stirring mixing tank 200 is provided with stirring driving device 201, and the output shaft lower end of stirring driving device 201 is connected with the stirring frame (not shown in the figure) that is arranged on stirring mixing tank 200 inner cavity, and stirring mixing tank The...

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Abstract

The invention belongs to the technical field of organic selenium preparation, and particularly relates to a preparation process and device of selenized chitosan oligosaccharide and application. Dissolving chitosan oligosaccharide in an acetic acid aqueous solution to obtain a chitosan oligosaccharide solution; sodium selenite is added into the chitosan oligosaccharide solution for ultrasonic treatment; carrying out centrifugal dialysis on the reacted mixed solution; carrying out suction filtration on the reaction concentrated solution, and then carrying out vacuum concentration on the filtrate obtained by suction filtration; adding absolute ethyl alcohol into the vacuum concentrated solution, standing after precipitate appears, performing centrifugal separation, washing the precipitate with absolute ethyl alcohol, and drying; the device comprises a rack, a stirring and mixing tank, a temperature control ultrasonic treatment tank, a centrifugal dialysis concentration device and a control box, according to the preparation device disclosed by the invention, the catalyst is the nickel particles attached to the heat dissipation fin group, the catalyst does not need to be filtered after the reaction, and the acetic acid smell easily emitted by the acetic acid can be completely filtered to remove peculiar smell and then is discharged, so that the reaction steps and the workshop environment are optimized.

Description

technical field [0001] The invention belongs to the technical field of organic selenium preparation, and in particular relates to a preparation process, device and application of selenized oligo-chitosan. Background technique [0002] As a cationic polysaccharide, chitosan has excellent biocompatibility, biodegradability, and no toxic side effects. Selenium is one of the essential trace elements for the human body. Selenium is mainly involved in metabolic pathways such as anti-oxidation, thyroid hormone synthesis and immune function in the body. The lack of selenium in the body can cause several chronic diseases such as cancer. With the further deepening of people's understanding of chitosan metal complexes, combined with the good biological activity of organic selenium compounds, more and more people have studied chitosan selenium. Oligomerization promotes the water solubility of chitosan, which is beneficial to promote absorption, and then maximize its biological activity...

Claims

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Application Information

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IPC IPC(8): C08B37/08A61K31/722A61P1/00B01F27/80B01J19/10
CPCC08B37/003A61K31/722A61P1/00B01J19/10
Inventor 吴其平李海兵刘立明
Owner ZHONGHEFA BEIJING BIOLOGICAL SCI & TECH DEV
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