Miniature ultra-low field nuclear magnetic resonance spectrometer

Abstract

The invention discloses a small ultra-low field nuclear magnetic resonance spectrometer, which comprises a sample flowing module for driving a liquid sample to flow between a polarization region and a detection region; the hyperpolarization module is used for polarizing the liquid sample; the probe and sample fixing module is used for fixing the detection area sample tube and the nuclear magnetic detection module; the pulse applying module is used for applying a pulse to the liquid sample, transferring a nuclear magnetization vector of the sample to a transverse direction, and carrying out free evolution of sample spinning; the nuclear magnetic detection module is used for detecting a free evolution spinning signal of the liquid sample and converting the free evolution spinning signal into a voltage signal; the magnetic shielding module shields a geomagnetic field to ensure an ultra-low field environment; and the time sequence control module is used for controlling each module to work and collecting voltage signals. Through the combination of the modules, the detection process is carried out in a magnetic shielding environment, the dependence of a traditional nuclear magnetic resonance spectrometer on a strong magnetic field is eliminated, and the system complexity and the manufacturing cost are effectively reduced; the device is simple in overall structure, small in size, convenient to move and capable of adapting to nuclear magnetic detection in various environments.

Description

technical field [0001] The invention belongs to the technical field of nuclear magnetic resonance, and in particular relates to a small ultra-low-field nuclear magnetic resonance spectrometer used for detecting the substance composition of liquid samples. Background technique [0002] Nuclear magnetic resonance technology is based on the widespread existence of nuclear spin in matter. Using this technology to accurately, quickly and non-destructively obtain information on the composition and structure of matter is one of the most important material exploration technologies in contemporary science. It is also widely used in physics, chemistry, biology, medicine, engineering and many other fields. [0003] Traditional NMR spectrometers are mostly high-field spectrometers. The high-field spectrometer measures signals by means of electromagnetic induction. The probe acts as a link between the sample and the spectrometer, and its outer layer is wound with multiple sets of coils,...

AI Technical Summary

Problems solved by technology

Improving the magnetic field strength is the main method to improve the sensitivity of the high field spectrometer, but as the magnetic field becomes stronger, the requirements for the design, processing and installation of the magnet are also higher, and the low temperature system used to generate a strong magnetic field ensures the uniformity of the magnetic field The shimming system is becoming more and more complex, making the high-field spectrometer complex in structure, bulky and expensive

[0004] The development of the zero magnetic field NMR spectrometer has also achieved many achievements, but the zero magnetic field NMR spectrometer needs to build a complex optical path, and has extremely high requirements on the stability of the optical path, so it can only work in a quiet, stable, constant temperature and constant pressure environment. in a humid environment

Moreover, the current zero-field NMR spectrometer is large and heavy, with a size of 1-2 meters, so it is difficult to move and lacks flexibility

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