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Folium artemisiae argyi essential oil nano preparation as well as preparation method and application thereof

A technology for essential oils and preparations of argyi leaves, applied in the field of medicine, can solve the problems of low solubility, low stability of natural plant essential oils, poor antibacterial effect, etc., and achieve the effects of reducing bacterial content, good application prospect and good antibacterial effect.

Pending Publication Date: 2022-04-08
ZHENGZHOU UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is to overcome the technical problems of low stability, low solubility and poor antibacterial effect of natural plant essential oils in the prior art, and provide a kind of oil with better water solubility and stability and better antibacterial effect. Artemisia argyi essential oil-hydroxypropyl-β-cyclodextrin nano-preparation

Method used

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  • Folium artemisiae argyi essential oil nano preparation as well as preparation method and application thereof
  • Folium artemisiae argyi essential oil nano preparation as well as preparation method and application thereof
  • Folium artemisiae argyi essential oil nano preparation as well as preparation method and application thereof

Examples

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Embodiment 1

[0032] The present invention adopts saturated absolute ethanol solution method and decompression rotary steaming technology to prepare natural plant essential oil-hydroxypropyl-β-cyclodextrin nano-preparation, and the preparation process of the present invention is as follows figure 1 shown.

[0033] The preparation method is: add 10g of hydroxypropyl-β-cyclodextrin into the absolute ethanol solution to prepare the hydroxypropyl-β-cyclodextrin solution; slowly add 5g of Artemisia argyi essential oil into the above solution, and stir at a constant temperature of 45°C for 3h , the solution was evaporated by a rotary evaporator, and dried in an oven at 60°C.

[0034] Take mugwort essential oil, mugwort essential oil-hydroxypropyl-β-cyclodextrin nano-preparation, hydroxypropyl-β-cyclodextrin, and detect its absorbance in the range of 200-800 wavelengths, figure 2 It is the full-wavelength scanning image of Artemisia argyi essential oil (1), Artemisia argyi essential oil-hydroxyp...

Embodiment 2

[0037] Set the mass ratio of mugwort essential oil: hydroxypropyl-β-cyclodextrin to 1:10, 1:8, 1:6, 1:4, 1:2.5, 1:2, 1:1.5, 1:1; The temperature was set at 75°C, 60°C, and 45°C; the reaction time was set at 1h, 3h, and 5h.

[0038] as the picture shows, Figure 4a -c is the result graph of the influence of temperature and time on the encapsulation efficiency, drug loading and yield of Folium Artemisiae Argyi essential oil-hydroxypropyl-β-cyclodextrin, Figure 5a -b is the diagram of the effect of different mass ratios of Artemisia argyi essential oil: hydroxypropyl-β-cyclodextrin on the encapsulation efficiency and drug loading of nano-preparations. The results showed that when the mass ratio of Artemisia argyi essential oil: hydroxypropyl-β-cyclodextrin was 1:2-2.5, the reaction temperature was 45°C, and the reaction time was 3 hours, when the drug loading was used as the main index, the Artemisia argyi at this time The drug loading, encapsulation efficiency and yield of es...

Embodiment 3

[0040] The nano-preparation obtained in Example 2 is used for space antibacterial research.

[0041]The nano-preparation of Artemisia argyi leaf essential oil of the present invention is put into a humidifier, and the nano-inclusion complex dissolves rapidly in the water tank of the humidifier, and the oscillator is used to drive the atomizing vibrator to generate resonance to form an ultrasonic wave, and according to the micro-shock wave theory and surface tension wave theory, the water solution is generated. Atomization, under the impetus of the fan, the atomized nano-preparation is sent to the air through the pipeline along with the water mist. After entering the air, the plant essential oil in the preparation "escapes" into the air immediately, achieving a good effect of antibacterial and disinfection in the air.

[0042] Control group: space 17-18m 3 After fumigation with distilled water for 3 hours, the number of colonies in the air was collected by the microbial sample...

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Abstract

The invention belongs to the technical field of medicines, and discloses a folium artemisiae argyi essential oil nano preparation as well as a preparation method and application thereof, hydroxypropyl-beta-cyclodextrin is taken as a carrier, folium artemisiae argyi essential oil is included in the hydroxypropyl-beta-cyclodextrin, and an inclusion compound is formed. The folium artemisiae argyi essential oil nano preparation is good in water solubility and high in stability and can be used in the humidifier, the folium artemisiae argyi essential oil nano preparation is sprayed out along with water mist by means of power, and the good effects of bacteriostasis, disinfection and air purification are achieved; by utilizing the characteristic of small particle size, the nebulizer is used for preventing and treating respiratory diseases, such as nebulization treatment of asthma and rhinitis, the medicine can directly reach the focus, the effect is direct, the toxic and side effects relative to the whole body are less, the disease course is shortened, and the compliance of a patient is greatly improved.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a nano-preparation of Artemisia argyi essential oil used in a humidifier and atomized drug delivery, its preparation method and application. Background technique [0002] Smoked mugwort has been widely used since ancient times, such as "Zhuangzi" in the Spring and Autumn Period, "Yue people smoke with moxa". However, studies have shown that moxa smoke can cause chronic pharyngitis and even allergies due to the presence of harmful substances such as naphthalene, phenol, and CO. , so that the taste and sense of smell gradually decline and many other shortcomings, and the shortcomings of moxa smoke are relatively strong and prone to fire, which limits its scope of use. Extracting the active ingredients from the Artemisia argyi leaves and preparing them into essential oils can reduce the toxic effect. The prepared volatile oil can exhibit various functions, including relieving ast...

Claims

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Application Information

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IPC IPC(8): A61K47/69A61K9/12A61K36/282A61P11/06A61P11/00A61P11/02A01N65/12A01N25/10A01P1/00
Inventor 徐霞张婧娴吴德巧周慧廖兴林可钰陈迪
Owner ZHENGZHOU UNIV