Implantable electrical stimulation conductive support and preparation method thereof
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A conductive stent and electrical stimulation technology, applied in the field of biomedicine, can solve the problems of complex material preparation process, lack of customized electric field design, lack of adaptation to different biological tissues, etc., and achieve the effect of high biocompatibility
Active Publication Date: 2022-04-12
海宁市产业技术研究院
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However, this technical solution still has the following disadvantages: a) lack of customized electric field design, and the isotropic electric field distribution is determined only by external electrodes; b) the material preparation process is complicated; c) lack of adaptation to different biological tissues, the process only for nerve cells
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[0045] A preparation method of a conductive support for implantable electrical stimulation, the specific steps are as follows:
[0046] 1. Preparation of two inks
[0047] 1.1 Preparation of PLGA-graphene conductive ink
[0048] The process flow of the ink is as follows figure 1 As shown, the specific process is:
[0049] Using the liquid phase stripping process, add an appropriate amount of surfactant (EGBE) and plasticizer (DBP) dropwise in excess dichloromethane (10ml-20ml), stir and mix, then add the graphene powder corresponding to the required volume fraction, and stir After mixing, put it into an ultrasonic instrument and cover it with a cover at room temperature for 3-4 hours at a power of 400W, so that the graphene powder is fully dispersed, and a single-layer and multi-layer aqueous dispersion of graphene nanosheets is obtained.
[0050] Finally, an appropriate amount of PLGA was dissolved in excess dichloromethane, and mixed evenly by magnetic stirring to obtain ...
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Abstract
The invention discloses an implantable electrical stimulation conductive stent and a preparation method thereof, and belongs to the technical field of biomedicine. The method comprises the following steps: S1, preparing conductive ink and non-conductive ink; S2, designing different electric field distributions through selection and layer-by-layer stacking of the conductive ink and the non-conductive ink; and S3, according to the designed electric field distribution, the conductive support is printed with conductive ink and non-conductive ink through a direct extrusion type double-nozzle 3D printer. According to the invention, the conductive stent is prepared by adopting the conductive and non-conductive mixed ink, so that the customized design of a conductive network is realized, and different customized electrical stimulation requirements can be met; the direct-writing ink is simple in preparation process, free of post-treatment, high in material utilization rate and low in loss; the mixed printing of the two inks with different mechanical properties can realize the preparation of scaffolds with different mechanical strengths, and is used for coupling with biological tissues with different mechanical properties.
Description
technical field [0001] The invention relates to a preparation method of a conductive support, in particular to an implantable electrical stimulation conductive support and a preparation method thereof, belonging to the technical field of biomedicine. Background technique [0002] In the field of biomedical technology, electro-stimulation conductive stents mainly involve the preparation of conductive materials, the design of structures, and the design of host computers, etc., and can be applied to the repair of various parts of organisms, including bones, nerves, blood vessels, muscles, tendons, skin, Bile duct, lymph, esophagus, trachea, intestine, uterus, etc. Most of the existing conductive supports are made of pure conductive materials or composite conductive materials, and the structural design is simple, lacking the structural design of the conductive network. The main materials include: PANI, PG, PPY, PCL / PPy, PLAAP, PPY / chitosan, etc. The structure is mostly a pure c...
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