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Bionic stent for peripheral nerve injury

A nerve repair and nerve tissue technology, applied in the field of bionic scaffolds, can solve the problems of increased surgical time and complexity, high incidence of donor sites, random axon growth direction, etc.

Pending Publication Date: 2022-04-12
RGT UNIV OF CALIFORNIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Disadvantages of autografts include: 1) high donor site morbidity; 2) limited supply of donor grafts; and 3) increased surgical time and complexity
However, one disadvantage of cellular implants is the lack of three-dimensional (3D) organization, resulting in random axonal growth directions; most axons do not regenerate into the host tissue beyond the site of injury, so functional recovery is extremely conservative, if any

Method used

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  • Bionic stent for peripheral nerve injury
  • Bionic stent for peripheral nerve injury
  • Bionic stent for peripheral nerve injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] Example 1. Multi-channel scaffold for nerve injury repair in rat model

[0069] In some embodiments, the device is made of porous PCL and includes linear microchannels. The entire device has an inner diameter of 1.6 mm and a length of 10 mm, with a 1 mm overhang at each end of the outer sheath (eg, for suturing in place within the subject). To assess the efficacy of these devices for nerve repair, the devices were tested in a rat sciatic nerve model. Images of intact sciatic nerves in rats are shown at Figure 12 middle. Animals were housed (eg, 2-3 per cage) with free access to food and water in a facility approved by the American Association for the Accreditation of Laboratory Animal Care. All animal studies were performed according to the NIH Laboratory Animal Care and Safety Guidelines and in accordance with protocols approved by the San Diego VA Healthcare System Institutional Animal Care and Use Committee.

[0070] For device implantation (n=6), animals were d...

Embodiment 2

[0073] Example 2. Multi-channel scaffold for nerve injury repair in rat model

[0074] Multichannel scaffolds prepared by embossing were implanted into 1-cm-long defects of the rat sciatic nerve and compared with autologous sural nerve grafts or open-canalized implants. The scaffold used in this example has 8 microchannels, each with a diameter of approximately 200 microns. The stent is 1cm long and has an outer diameter of 1.7mm. Example images of scaffolds implanted in rats are shown in Figure 13 middle. The multichannel scaffolds 4 weeks after implantation supported linear alignment and accelerated regeneration of axons at the site of injury. Multichannel stents at 6 months post-implantation showed improved connectivity between the spinal cord and gastrocnemius muscle, comparable to autografts, compared to open-cannulation therapy. In addition, the multichannel stent supported increased muscle mass that doubled compared to lesion-only or open-tube therapy and was compa...

Embodiment approach

[0089] The following embodiments describe non-limiting permutations of combinations of features disclosed herein. Other permutations of combinations of features are also contemplated. In particular, each of these numbered embodiments is contemplated to be dependent on or relate to each preceding or subsequent numbered embodiment, regardless of the order in which they are listed.

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Abstract

Disclosed herein are biomimetic scaffolds for nervous tissue growth having a plurality of microchannels disposed within a sheath. Each microchannel includes a porous wall formed of a biocompatible and biodegradable material. The biocompatible and biodegradable material may be a poly (ethylene glycol) diacrylate, a methacrylated gelatin, a methacrylated collagen, or a polycaprolactone, and combinations thereof. The bionic stent has a high open volume percentage, can achieve excellent (linear and high fidelity) nervous tissue growth, and meanwhile reduces inflammation near an in-vivo implantation site to the maximum extent.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of U.S. Provisional Patent Application 62 / 832,681, filed April 11, 2019, which is hereby incorporated by reference in its entirety. technical field [0003] The present invention relates to biomimetic scaffolds comprising porous microchannels to facilitate the growth of neural tissue and methods of making such scaffolds. Background technique [0004] Although the regenerative capacity of the peripheral nervous system (PNS) is greater than that of the central nervous system (CNS), functional regeneration after injury is largely incomplete if injured axons are misplaced or lose contact with innervated tissues of. This results in major functional deficits, including insufficient reinnervation of target tissues and painful neuroma formation. [0005] Factors affecting PNS regeneration include the nature and extent of the injury itself, the timing of denervation, the type and diameter ...

Claims

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Application Information

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IPC IPC(8): A61F2/02A61L27/18A61L27/22A61L27/34A61L27/54A61L27/56
CPCA61L27/222A61L27/18A61L27/26A61L27/24A61L2430/32A61L27/54A61L2300/414B33Y80/00B33Y70/00A61B17/1128A61B2017/1132C08L71/02C08L67/04C08L89/06A61B2017/00004A61B2017/00526A61B2017/00893
Inventor 伊萨克·拉扎罗维茨马克·H·图辛斯基雅科夫·克夫勒
Owner RGT UNIV OF CALIFORNIA
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