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Vascular closure composition for treating varicosity

A technique for vascular closure and varicose veins, applied in the field of medicine, to achieve the effects of short time-consuming, low treatment cost and simple operation

Pending Publication Date: 2022-04-26
SHANGHAI YISIMIAO MEDICAL INSTR CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the problem that the treatment means for treating varicose veins in the above-mentioned prior art has various shortcomings, the present invention provides a blood vessel closure composition for treating varicose veins

Method used

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  • Vascular closure composition for treating varicosity
  • Vascular closure composition for treating varicosity
  • Vascular closure composition for treating varicosity

Examples

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Effect test

preparation example Construction

[0060] Thickeners include: nylon, polypropylene, polyethylene, polyether ether ketone, starch, cellulose, polylactic acid, polyglycolide, polycyanoacrylates, especially polycyanoacrylates, more preferably It is polybutyl cyanoacrylate and the like. In a preferred embodiment, the thickener is poly(n-butyl cyanoacrylate), and its preparation method includes: measure 200ml of deionized water, add 1ml of ammonia water, stir, cool down to 0°C, and mix 10ml of cyanoacrylate under rapid stirring. Slowly add n-butyl acrylate to the above solution dropwise, after the drop is complete, raise to room temperature and continue to stir for 3 hours, then filter; transfer the obtained solid to 100ml of isopropanol solution for beating for 2 hours, then filter to obtain a white solid, put the white solid in the blast After drying in an oven at 40-50°C, 9.1 g of white solid was collected, with a yield of 92.3%.

[0061] Antioxidants

[0062] Antioxidants include: butylated hydroxytoluene, hyd...

Embodiment

[0068]

[0069] It can be seen that the vascular closure composition of the present invention has a good venous vessel sealing effect, and the structure of the adhesive of the vascular closure composition contains iodine-containing group triiodophenol or triiodobenzoic acid, which has autographic Function, no need to add additional nanoparticles such as tantalum, gold, platinum, zirconium, zirconia or barium sulfate, bismuth carbonate as developer, so as to avoid the harm caused by the developer staying in the body for a long time.

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Abstract

The present invention relates to a vascular closure composition for treating varicosity comprising 50 wt% to 85 wt% of a binder comprising at least one of the following compounds 1A, 1B, 1C, 2A, 2B and 2C, 10 wt% to 30 wt% of a plasticizer, 5 wt% to 20 wt% of a thickener, 0.1 wt% to 1 wt% of an antioxidant, and 0.1 wt% to 5 wt% of a polymerization inhibitor. According to the blood vessel closure composition for treating varicosity, the purpose of closing a venous access is achieved by closing lesion veins through the adhesive, and the blood vessel closure composition has the advantages that the operation is simple, and the operation can be performed in an outpatient service; no heat is generated when blood vessels are adhered during operation, and the adhesive can be developed; stretch socks do not need to be worn after the operation; the whole treatment process is short in time consumption; the treatment cost is low.

Description

technical field [0001] The present invention relates to medicines, more particularly to a blood vessel closing composition for treating varicose veins. Background technique [0002] Varicose veins refer to tortuous and dilated veins due to factors such as blood stasis and weak venous walls. Varicose veins can occur in multiple parts of the body. For example, hemorrhoids are actually a type of varicose veins. Clinically visible varicose veins include esophageal and gastric fundus, varicocele, and abdominal wall varicose veins. The most common site of varicose veins is the lower extremities. It is worth noting that varicose veins are a secondary manifestation of other lesions, so timely treatment should be given to varicose veins. [0003] At present, there are two main ideas for the treatment of varicose veins. The first is to remove the vein. The main treatment method is surgical stripping. The second idea is to block the venous access. The main treatment methods include l...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/06A61L24/02A61L24/00
CPCA61L24/06A61L24/02A61L24/001A61L24/0021A61L2430/36C08L35/04
Inventor 孙鹏郭晓勇刘翠钗李凤杰张世文焦吉文
Owner SHANGHAI YISIMIAO MEDICAL INSTR CO LTD
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