Application of traditional Chinese medicine monomer composition in prevention and/or treatment of alcoholic stomach injury

Abstract

The invention provides a medicine composition for preventing and / or treating alcoholic stomach injury. The medicine composition comprises berberine hydrochloride, palmatine hydrochloride, evodiamine and rutaecarpin. The invention provides an application of a drug combination of berberine hydrochloride, palmatine hydrochloride, evodiamine and rutaecarpin in a drug for preventing and / or treating alcoholic stomach injury. Research finds that the pharmaceutical composition can significantly improve pathological changes of stomach tissues in an acute alcohol stomach injury rat model, can significantly improve functional indexes (improving superoxide dismutase (SOD) activity and reducing malondialdehyde (MDA) and gastrin (GAS) content) in serum of acute alcohol injury modeling rats, can reduce indexes of inflammatory factors (IL-1, iNOS and TNF-alpha), and can significantly reduce inflammatory factors (IL-1, iNOS and TNF-alpha) in serum of the acute alcohol injury modeling rats. The gene expression and the protein expression of inflammatory factors (IL-1, IL-6 and TNF-alpha) in stomach tissues are reduced, and a good effect of relieving the alcoholic stomach injury is achieved.

Description

technical field [0001] The invention relates to the field of pharmaceutical compositions, in particular to the application of a composition comprising berberine, palmatine, evodiamine and evodiamine in preventing and / or treating alcoholic gastric damage. Background technique [0002] In recent years, with the change of lifestyle and dietary structure and the increase of wine varieties and production, the proportion of alcohol drinkers is gradually increasing. The main component of wine is ethanol, because of its fat solubility, it is highly corrosive to gastric mucosal tissue, destroys the surface mucus layer and cervical mucus cells, and destroys the physiological environment required for normal metabolism of gastric mucosa. After ethanol is metabolized into acetaldehyde in the gastric mucosa, acetaldehyde binds to gastric mucosal proteins and participates in the damage to the gastric mucosa. Its local toxicity may be related to the occurrence of gastric cancer. Absolute e...

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Problems solved by technology

[0005] CN1682807 discloses a kind of Zuojin dripping pill, which is composed of berberine hydrochloride, Evodia rutaecarpa extract containing evodiamine and an optional carrier as a mechanism, berberine hydrochloride: Evodia rutaecarpa extract=60:1, (berberine hydrochloride Alkaline+Evodia rutaecarpa extract): matrix=60:1; CN 1969973 A discloses a Zuojin soft capsule; CN 10289538OA discloses a production process of Zuojin tablets; CN 104758241 A discloses Zuojin soft capsule for treating gastric pain Gold microemulsion gel and its preparation method; CN110680924 A discloses Zuojin Pill’s regulation and application of Zuojin Pill on the ROCK / PTEN / PI3K signaling pathway in human gastric cancer drug-resistant cells; The preparation method, it can be seen that the optimization of Zuojinfang is mainly in the process and preparation, and the pharmacological effect is not reflected. At the same time, the active ingredients are not clear, and the stability of the drug quality cannot be guaranteed. Therefore, it is especially important to choose more effective anti-ulcer drugs. important

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