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Composition prepared from pine pollen and curcuma, preparation method thereof, and application of composition in preparing medicament for treating inflammatory bowel disease

A technology of inflammatory bowel disease and composition, applied in medicine, from the field of composition of pine pollen and turmeric and its preparation, can solve the problems of IBD etiology and pathogenesis not fully clarified

Active Publication Date: 2013-07-17
YANTAI NEW ERA HEALTH IND +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, the incidence of IBD has been on the rise at home and abroad, and the etiology and pathogenesis of IBD have not yet been fully clarified.

Method used

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  • Composition prepared from pine pollen and curcuma, preparation method thereof, and application of composition in preparing medicament for treating inflammatory bowel disease
  • Composition prepared from pine pollen and curcuma, preparation method thereof, and application of composition in preparing medicament for treating inflammatory bowel disease
  • Composition prepared from pine pollen and curcuma, preparation method thereof, and application of composition in preparing medicament for treating inflammatory bowel disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1: the preparation of turmeric extract

[0031] 1. Pass through a 40-mesh sieve after the dried Chinese herbal medicine turmeric is pulverized;

[0032] 2. Take 500 g of the powder obtained by sieving, and heat and reflux with 8 times the amount of 80% ethanol for 2 hours each time for extraction, and extract three times in total. After each extraction, filter the extract and combine the extract;

[0033] 3. Concentrate under reduced pressure and dry under reduced pressure until the turmeric extract extract has no alcohol taste, and 40 g of turmeric extract extract is obtained.

[0034] 4. Dissolve 40g of turmeric extract extract with ethyl acetate until it can be completely dissolved, add 100g of 80-120 mesh silica gel to make the silica gel fully absorb the total curcumin, and dry at 60°C under vacuum to obtain a silica gel mixing sample (reddish-brown), set aside.

[0035] 5. Weigh 1800g (200-300 mesh) of silica gel, put it in a chromatographic column (d...

Embodiment 2

[0038] Embodiment 2: from the preparation method of pine pollen and turmeric extract composition

[0039] Broken pine pollen and turmeric extract are mixed, and 0.9% physiological saline is used to form a suspension.

Embodiment 3

[0041] Take by weighing 150g of broken-wall pine pollen, 30g of the turmeric extract obtained in Example 1, mix evenly, cross 80 mesh sieves, add microcrystalline cellulose 200g, starch 90g as diluent to form the preparation formula, mix evenly, spray into 75% Ethanol is the soft material made of binder, granulated with a 24-mesh sieve, granulated after drying, mixed evenly, pressed into tablets, made into 1000 tablets, coated, and ready to be obtained. Each tablet contains broken-walled pine pollen and turmeric extract Mixture 180mg.

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Abstract

The invention provides a composition prepared from pine pollen and curcuma, a preparation method thereof, and application of the composition in preparing a medicament for treating inflammatory bowel disease, relating to a composition prepared from plants and a preparation method and application thereof. The composition provided by the invention has a repairing effect on the mucous membrane of colon with lesion, and after a mouse with inflammatory bowel disease is treated by the composition, the MDA (malondialdehyde) content is reduced and the activity of SOD (super oxide dismutase) is improved, so that the composition can be used for preparing a medicament for treating inflammatory bowel disease. The composition comprises the following components in parts by weight: 1-10 parts of wall-broken pine pollen and 1 part of curcuma extract, wherein the curcuma extract is composed of curcumin, demethoxycurcumin and bisdemethoxycurcumin in mass ratio of (6-8):(1.5-2.5):(0.7-1.3).

Description

technical field [0001] The present invention relates to a composition from plants and its preparation method and application, in particular to a composition from pine pollen and turmeric, its preparation method and the application of the composition in the preparation of medicines for treating inflammatory bowel disease . Background technique [0002] Inflammatory bowel disease (IBD) is a group of chronic intestinal inflammatory diseases of unknown etiology, including ulcerative colitis (UC) and Crohn's disease (CD). In recent years, the incidence of IBD has been on the rise at home and abroad, and the etiology and pathogenesis of IBD have not yet been fully clarified. It is known that the inflammatory response caused by the abnormal response of the intestinal mucosal immune system plays an important role in the pathogenesis of IBD, which is considered to be caused by the interaction of multiple factors such as environment, genetics, infection and immune factors. The compl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9066A23L1/29A61P1/00A23L33/00
Inventor 刘志河刘珂石丽花刘军锋王桐范华英尹利端魏星邵萌
Owner YANTAI NEW ERA HEALTH IND
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