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Dendrobium officinale composition as well as preparation method and application thereof

A technology of Dendrobium officinale and a composition, applied in the field of medicine, can solve the problems of aggravating symptoms and aggravating ulcerative colitis in patients with ulcerative colitis, and achieve the effects of improving colonic mucosal damage, increasing colon length, and definite curative effect

Pending Publication Date: 2022-04-29
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Some drugs used to treat stomach heat and gastritis may have no therapeutic effect on ulcerative colitis, and may even have side effects of aggravating the symptoms of patients with ulcerative colitis, just like the traditional Chinese medicine composition commonly used by Academician Xiaolin to directly treat stomach heat, and Not used in the treatment of ulcerative colitis; cimetidine used to prevent erosive gastritis often has diarrhea as a side effect, and can even cause chronic peptic ulcer perforation, which can aggravate the symptoms of patients with ulcerative colitis

Method used

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  • Dendrobium officinale composition as well as preparation method and application thereof
  • Dendrobium officinale composition as well as preparation method and application thereof
  • Dendrobium officinale composition as well as preparation method and application thereof

Examples

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Effect test

Embodiment 1

[0025] Weigh 10 parts of Dendrobium candidum and 5 parts of Asparagus, mix the two medicinal materials, add water 50 times the total weight of the medicinal materials, soak for 2 hours, reflux extraction 5 times, the extraction temperature is 100 ° C, the extraction time is 6 hours, after the extract is filtered, the filtrate Concentrate under reduced pressure at a concentration temperature of 80°C to obtain the extract of the traditional Chinese medicine composition.

Embodiment 2

[0027] Weigh 5 parts of Dendrobium candidum and 20 parts of Asparagus, mix the two medicinal materials, add water 5 times the total weight of the medicinal materials, soak for 1 hour, reflux extraction once, the extraction temperature is 70 ° C, the extraction time is 1 hour, after the extract is filtered, the filtrate Concentrate under reduced pressure at a concentration temperature of 35° C. to obtain the extract of the traditional Chinese medicine composition.

Embodiment 3

[0029] Weigh 50 parts of Dendrobium candidum, add water 10 times the total weight of medicinal materials, soak for 12 hours, reflux extraction twice, the extraction temperature is 80°C, the extraction time is 2h, after the extract is filtered, the filtrate is concentrated under reduced pressure at a concentration temperature of 60°C to obtain Chinese medicine composition extract.

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Abstract

The invention discloses a dendrobium officinale composition and a preparation method and application thereof.The dendrobium officinale composition is prepared from, by weight, 10-50 parts of dendrobium officinale and 5-30 parts of radix asparagi, the medicine components are mixed and smashed, a certain amount of water is added, the medicine components are soaked for a period of time and subjected to reflux extraction, an extracting solution is filtered, filtrate is subjected to vacuum concentration, and a traditional Chinese medicine composition extract is obtained. The composition disclosed by the invention has a relatively good prevention and treatment effect on ulcerative colitis, and can be used for remarkably reducing the disease activity score (DAI score) of a mouse with ulcerative colitis, increasing the colon length, improving the histological lesions such as colonic mucosa injury, inflammatory cell infiltration, goblet cell and mucus reduction and the like, and preventing and treating the ulcerative colitis. One of the ways for preventing and treating ulcerative colitis is to increase the abundance of UCG-007 bacteria in intestinal flora. The traditional Chinese medicine composition has the characteristics of simple formula and exact curative effect, and has better effect, lower cost and good market development and application prospects compared with single use of dendrobium officinale.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a composition of Dendrobium candidum and its preparation method and application. Background technique [0002] Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD), characterized by inflammatory cell infiltration in the colonic mucosa, clinical symptoms mainly manifested as weight loss, diarrhea, abdominal pain, bloody stool, etc., seriously affecting the normal work of patients and life. Epidemiological studies have shown that patients with inflammatory bowel disease have a significantly increased risk of colon cancer. In recent years, the incidence of UC has risen rapidly worldwide, and its impact on adults aged 30-40 is increasing. Due to its complex etiology, high risk of recurrence, and poor prognosis, it has become a major challenge in clinical treatment. [0003] At present, the clinical drugs used to treat UC mainly include aminosalicylic ...

Claims

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Application Information

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IPC IPC(8): A61K36/8984A23L33/105A61P1/04A61P1/00
CPCA61K36/8984A61K36/8965A61P1/04A61P1/00A23L33/105A23V2002/00A61K2300/00A23V2200/30A23V2250/21
Inventor 陈素红王惠莹吕圭源李波熊桃秀楚楚
Owner ZHEJIANG UNIV OF TECH
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