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Tubular material as well as preparation method and application thereof

A tubular and tubular technology, applied in the field of tubular materials, can solve the problems of nozzle blockage, destruction of temperature-sensitive components of materials, and discontinuous spinning, etc., to avoid uneven stress, uniform and controllable wall thickness, and mechanical properties. Uniform and stable effect

Active Publication Date: 2022-04-29
CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, the electrospinning method is to atomize the polymer into a tiny jet through the electrostatic atomization of the polymer solution. The conical tip is extended to obtain fiber filaments, and the fiber filaments are connected with a template to obtain a tubular material. This method is prone to problems such as nozzle clogging and spinning discontinuity
The solution casting method is to inject a solution between the hollow cylinder and the inner core, and the tubular material can be obtained after removing the solvent. However, this method needs to remove the solvent, and the removal of the solvent by heating may destroy the temperature-sensitive components contained in the material. components, the freezing method takes a long time to remove the solvent

Method used

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  • Tubular material as well as preparation method and application thereof
  • Tubular material as well as preparation method and application thereof
  • Tubular material as well as preparation method and application thereof

Examples

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preparation example Construction

[0056] The invention provides a method for preparing a pipe, comprising the following steps:

[0057]a) adding the polymer solution to the poor solvent, making the polymer diffuse on the surface of the poor solvent to form a film to obtain a polymer film, and the solvent in the polymer solution is dissolved in the poor solvent;

[0058] b) using a mold to crimp the polymer film on the surface of the poor solvent to obtain a rod;

[0059] c) removing the mold to obtain a pipe.

[0060] see figure 1 , figure 1 It is a schematic flow chart of the preparation method of the pipe provided by this application. The first step is to dissolve the polymer in a good solvent and then add it to a poor solvent. Crimp, remove the mold to obtain a pipe, or repeat the above steps to obtain a pipe comprising a multilayer polymer film.

[0061] In the present invention, firstly, the polymer is dissolved in its good solvent to obtain a polymer solution. In one embodiment, the polymer is a fil...

Embodiment 1

[0088] Polyurethane with a molecular weight of 80,000 was purchased from Shandong Youso Chemical Technology Co., Ltd., and N,N-dimethylformamide was used to prepare a solution at a concentration of 50 mg / ml. 5 drops at a rate of 10mL / min to the water surface at a distance of 5cm from the water surface, the solution will spread on the water surface to form a film, and then within 2min, use a polytetrafluoroethylene rod with a diameter of 5mm to directly wrap around the film from one side of the film. Shaft curling, the process is repeatable, see Figure 5 , Figure 5The schematic diagram of the crimping method of crimping and film formation provided by Example 1 of the present invention, the position of each crimp moves 3 cm to the right relative to the edge of the previous pipe, and the fourth crimp moves to the left 3 cm relative to the edge of the third crimp, that is, the same as the second crimp The position is the same, and according to this rule, the sixth, eighth, and ...

Embodiment 2

[0092] Polyurethane with a molecular weight of 30,000 is synthesized in the laboratory, using dimethyl sulfoxide to prepare a solution at a concentration of 150 mg / ml, and after it is completely dissolved, add 1 drop to the water surface at a distance of 3 cm from the water surface through an autosampler (same as the example) , the solution is spread on the water surface to form a film, and within 5 minutes, use a glass rod with a diameter of 5mm to curl from one side of the film, and each curl moves 5cm to the right relative to the edge of the previous pipe, as Figure 8 as shown, Figure 8 It is a schematic diagram of the curling method of curling and film formation provided by Example 2 of the present invention. Return to the first curling position when curling for the sixth time, and follow this rule, and measure until the wall thickness meets the requirements, then freeze it with liquid nitrogen and take it out. Pipes are obtained after trimming.

[0093] Carry out SEM c...

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Abstract

The invention provides a preparation method of a pipe, which comprises the following steps: a) adding a polymer solution into a poor solvent, diffusing a polymer on the liquid level of the poor solvent to form a film to obtain a polymer film, and dissolving the solvent in the polymer solution in the poor solvent; b) curling the polymer film on the liquid level of the poor solvent by adopting a mold to obtain a bar; and c) removing the mold to obtain the pipe. The invention further provides application of the pipe as an artificial tubular tissue. According to the method provided by the invention, introduction of a binder is avoided, so that the conditions that the obtained pipe is uneven in stress, easy to break and the like are avoided, and meanwhile, uniform and controllable wall thickness and uniform and stable mechanical properties can be realized. In addition, the method provided by the invention does not need complex equipment or heating, the whole process can be completed at room temperature, and thermal influence or thermal inactivation on active substances in the tubular material cannot be generated.

Description

technical field [0001] The invention belongs to the technical field of materials, and in particular relates to a tubular material, its preparation method and its application. Background technique [0002] In recent years, cardiovascular diseases have seriously endangered human health, and vascular transplantation has attracted more and more attention. The best choice for vascular transplantation is the use of autologous blood vessels, but its sources are limited and cannot meet people's needs for vascular transplantation. Therefore, it is particularly important and urgent to prepare small-caliber artificial blood vessels that can replace autologous blood vessels for transplantation. [0003] The prior art discloses a variety of methods for preparing artificial blood vessels, mainly including: electrospinning method, solution casting method, leaching and coagulation method, film curling method and the like. Among them, the electrospinning method is to atomize the polymer in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/18A61L27/16A61L27/50A61L29/04A61L29/06A61L29/14A61L29/12A61L27/40
CPCA61L27/18A61L27/16A61L27/507A61L27/50A61L29/06A61L29/041A61L29/14A61L2430/22B29C41/12B29C41/22B29K2025/06B29K2067/003B29K2067/046B29K2075/00B29L2023/001B29L2031/7532
Inventor 杨小牛李硕吕红英杨磊涂江山吴海洋
Owner CHANGCHUN INST OF APPLIED CHEMISTRY - CHINESE ACAD OF SCI
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