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Continuous production system and ibuprofen rearrangement reaction continuous production process

A production system and production process technology, applied in chemical/physical/physical-chemical stationary reactors, chemical/physical/physical-chemical processes, organic chemistry, etc. It can improve the reaction efficiency and product conversion rate, improve the heat exchange efficiency, and avoid side reactions.

Pending Publication Date: 2022-04-29
QINGDAO UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The heat release of ibuprofen rearrangement reaction in the production process is nonlinear. In different reaction stages, with the intensity of the rearrangement reaction, the heat release will change greatly. However, the traditional ibuprofen production process cannot well adapted to the exothermic phase of the exhaust reaction
For example, in the invention patent with the application number "201910263435.8" and the name "a method for continuous production of ibuprofen ester", it is equipped with multi-stage rearrangement reactors, so that the rearrangement reaction of ibuprofen can be carried out in multiple series The continuous rearrangement reactor is carried out sequentially, and the multi-stage reactions are all overflow discharges, but it does not disclose that the multi-stage rearrangement reactor can adapt to different stages of the rearrangement reaction

Method used

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  • Continuous production system and ibuprofen rearrangement reaction continuous production process
  • Continuous production system and ibuprofen rearrangement reaction continuous production process

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Embodiment 1

[0030] This embodiment provides a continuous production system, including a preheating stage, a first-stage reactor 1 and a second-stage reactor 2 connected in sequence, and the heat release of the reaction materials in the first-stage reactor 1 is greater than that in the second-stage reaction The heat release of the reactor 2, the first stage reactor 1 and the second stage reactor 2 are respectively provided with a first heat exchange part 5 and a second heat exchange part 6, and the first heat exchange part 5 is fed into a circulating cold medium for To lower the temperature, the second heat exchange part 6 is fed with a circulating heat medium for heat preservation, which is used to maintain the reaction temperature of the first-stage reactor 1 and the second-stage reactor 2 within the same temperature range.

[0031] In this embodiment, by setting the first-stage reactor 1 and the second-stage reactor 2 in series, the reaction materials are reacted in the first stage respe...

Embodiment 2

[0042] The present embodiment provides a continuous production process of ibuprofen rearrangement reaction implemented by the above-mentioned continuous production system, comprising the following steps:

[0043] 1) Put the ketal and the catalyst into the preheating kettle 3 for preheating;

[0044] 2) After the preheating is completed, the mixed materials are passed into the spiral coil of the first stage reactor 1 for reaction. During the reaction, a circulating cold medium is passed into the first heat exchange part 5 to take away the heat released by the reaction, and the temperature is reduced. Control at 140℃~150℃;

[0045] 3) The material reacted in the first-stage reactor 1 flows into the second-stage reactor 2, and the content of the rearranged ester of the material reaches 70% to 80% after the reaction in the first-stage reactor 1; Circulating heat medium is passed into part 6 for heat preservation, and the temperature is controlled at 140°C to 150°C;

[0046] 4) A...

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Abstract

The invention discloses a continuous production system and an ibuprofen rearrangement reaction continuous production process, and relates to the technical field of chemical pharmaceutical equipment.The continuous production system comprises a preheating stage, a first-stage reactor and a second-stage reactor which are sequentially connected, and the first-stage reactor and the second-stage reactor are provided with a first heat exchange part and a second heat exchange part respectively; a circulating cold medium is introduced into the first heat exchange part for cooling, and a circulating hot medium is introduced into the second heat exchange part for heat preservation; the two reaction stages, with different heat release rates, of the reaction materials are conducted in the first-stage reactor and the second-stage reactor respectively, the first-stage reactor is refrigerated in cooperation with the first heat exchange part, the second-stage reactor is subjected to heat preservation in cooperation with the second heat exchange part, the reaction temperature can be precisely regulated and controlled, and the reaction efficiency is improved. Side reaction caused by violent fluctuation of the reaction temperature is avoided, and the reaction efficiency and the product conversion rate are improved.

Description

technical field [0001] The invention relates to the technical field of chemical and pharmaceutical equipment, in particular to a continuous production system and a continuous production process of ibuprofen rearrangement reaction. Background technique [0002] As a non-steroidal anti-inflammatory drug, ibuprofen has anti-inflammatory and analgesic effects 16 to 32 times stronger than aspirin, and its antipyretic effect is similar to that of aspirin but longer lasting, with an average antipyretic effect of 4 to 6 hours; Gastrointestinal side effects are mild and easy to tolerate, and the gastrointestinal irritation is the lowest among such drugs; and the adverse reactions are less and milder than aspirin, and have no obvious side effects on the hematopoietic system such as liver, kidney and platelets. Today ibuprofen has been widely used in the treatment of rheumatoid arthritis, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, neuritis, pharyngitis and bronchitis...

Claims

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Application Information

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IPC IPC(8): B01J19/24C07C67/00C07C69/65
CPCB01J19/0013B01J19/243B01J19/245C07C67/00B01J2219/00094C07C69/65
Inventor 朱兆友崔培哲王英龙齐建光李鑫孟凡庆贾建波寇祖星马通
Owner QINGDAO UNIV OF SCI & TECH