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Virus-imitated DNA (deoxyribonucleic acid) polyhedral frame structure as well as preparation method and application thereof

A frame structure and polyhedron technology, which is applied in the field of DNA nanometers, can solve the problems of simulating the packaging process of virus genome and downstream functions, and its rigidity is not strong, and achieves the effects of good application ability, not easy to collapse, and good structural rigidity.

Active Publication Date: 2022-05-06
RENJI HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, few nanomaterials currently have icosahedral structures, and a few nanomaterials with icosahedral structures are only single-layer structures, and the rigidity is not strong; Research on the packaging process and downstream functions of viral genomes simulated by using nucleic acid nanostructures

Method used

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  • Virus-imitated DNA (deoxyribonucleic acid) polyhedral frame structure as well as preparation method and application thereof
  • Virus-imitated DNA (deoxyribonucleic acid) polyhedral frame structure as well as preparation method and application thereof
  • Virus-imitated DNA (deoxyribonucleic acid) polyhedral frame structure as well as preparation method and application thereof

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Embodiment Construction

[0039] The specific implementation manners of the present invention will be further described below in conjunction with the drawings and examples. The following examples are only used to illustrate the technical solution of the present invention more clearly, but not to limit the protection scope of the present invention.

[0040] The present invention relates to a double-layered icosahedron DNA polyhedron frame structure and its packaging assembly composition under the background of DNA origami, and also provides a method for making the DNA polyhedron frame structure and its packaging assembly composition Methods. On the other hand, the present invention also relates to the application of the above materials and their compositions at different levels, for reference and implementation by those skilled in the art.

[0041] Imitation virus DNA polyhedron frame structure

[0042] Such as Figure 8As shown, the present invention describes a DNA polyhedron framework structure,...

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Abstract

The invention relates to a virus-imitated DNA polyhedral frame structure, which is a regular icosahedron frame structure, each edge is composed of four DNA double helixes, the virus-imitated DNA polyhedral frame structure is provided with an outer layer structure and an inner layer structure, the edges at the vertexes of the outer layer structure are bridged by five T single-stranded DNA, and the edges at the vertexes of the inner layer structure are bridged by one T. In addition, the invention further relates to a packaging and assembling composition containing the DNA material and a construction and manufacturing method of the composition. Finally, the invention also relates to application of the DNA polyhedral frame structure in the fields of nano space molecule operation level, acellular in-vitro amplification system and virus infection simulation. The DNA polyhedral frame structure recorded in the invention is a regular icosahedron, and compared with the prior art, the DNA polyhedral frame structure has a unique double-layer structure and more anchor points, so that the DNA polyhedral frame structure has better structural rigidity, and an assembly prepared from the DNA polyhedral frame structure also has better integrity and more complete packaging; and compared with the prior art, the application of the method in various fields also has substantive progress.

Description

technical field [0001] The invention relates to the field of DNA nanotechnology, in particular to a DNA polyhedron frame structure with an icosahedral structure, a preparation method and application thereof. Background technique [0002] Nanomaterials refer to materials that have at least one dimension in a three-dimensional space that is in the nanometer size (1-100nm) or is composed of them as basic units. Among many nanomaterials and related technologies, since the invention of DNA origami in 2006, nucleic acid nanotechnology, with its precise structure editing ability, has shown great advantages in spatial organization and flexible and reliable controllable change ability of various other materials. . DNA molecule is a kind of molecule ubiquitous in nature. It is not just a carrier for organisms to store and transmit genetic information. The predictability and programmability of its complementary pairing make it a very potential nanostructure material. Binding and prec...

Claims

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Application Information

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IPC IPC(8): C12N15/11
CPCC12N15/10C07K14/005C12N2795/00022Y02A50/30
Inventor 杨洋徐芸芸施茜
Owner RENJI HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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