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Bionic system and method for in-vitro regulation and control of inorganic salt crystallization

A bionic system and inorganic salt technology, applied in chemical instruments and methods, separation methods, crystallization separation, etc., to achieve the effect of wide application range, easy operation, and easy construction

Pending Publication Date: 2022-05-13
DALIAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, related bionic systems and research methods that are universal and can precisely regulate the crystallization of inorganic salts in the body have not yet been reported in literature and related patents.

Method used

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  • Bionic system and method for in-vitro regulation and control of inorganic salt crystallization
  • Bionic system and method for in-vitro regulation and control of inorganic salt crystallization
  • Bionic system and method for in-vitro regulation and control of inorganic salt crystallization

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Experimental program
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Effect test

Embodiment 1

[0038] (1) Design and manufacture a membrane module 2 similar in structure to the human knee joint;

[0039] (2) Prepare non-toxic EGDMA-HEMA flat membrane 1 with good biocompatibility and mechanical properties similar to hyaline cartilage, the molar ratio of which is 3:5, and cut it into the size and shape matched with the membrane module 2;

[0040] (3) Assembling the membrane module 2 and the EGDMA-HEMA flat membrane 1 together;

[0041] (4) Prepare 2 bottles of 100mL simulated body fluid with a sodium ion concentration of 140mM and a pH of 7.4, and add 1.5mM uric acid to one of the bottles as a crystallization solution;

[0042] (5) Set the temperature of the environment where the inorganic salt crystallization module III is located, use the constant temperature module I to maintain the temperature at 20°C, and monitor it in real time through the thermometer 8;

[0043] (6) Pass the liquid outlet pipes of the crystallization liquid tank 6 and the simulated body fluid tank...

Embodiment 2

[0048] (1) Design and manufacture a membrane module 2 similar in structure to the human knee joint;

[0049] (2) Prepare non-toxic, good biocompatibility and hyaline cartilage mechanical properties similar to the EGDMA-HEMA-AA flat membrane 1, the molar ratio is 2:5:3, and cut it to match the membrane module 2 size and shape;

[0050] (3) Assembling the membrane module 2 and the EGDMA-HEMA-AA flat membrane 1;

[0051] (4) Prepare 2 bottles of 100mL simulated body fluid with a sodium ion concentration of 140mM and a pH of 7.4, and add 1.5mM uric acid to one of the bottles as a crystallization solution;

[0052] (5) Set the temperature of the environment where the inorganic salt crystallization module III is located, use the constant temperature module I to maintain the temperature at 20°C, and monitor it in real time through the thermometer 8;

[0053] (6) Through the polyvinyl chloride transparent hose, the liquid outlet pipes of the crystallization liquid tank 6 and the sim...

Embodiment 3

[0058] (1) Design and manufacture a membrane module 2 similar in structure to the human knee joint;

[0059] (2) Prepare non-toxic, good biocompatibility and hyaline cartilage mechanical properties similar to the EGDMA-AA flat film 1, the molar ratio of which is 3:5, and cut it into the size and shape matched with the film component 2;

[0060] (3) Assembling the membrane module 2 and the EGDMA-AA flat membrane 1;

[0061] (4) Prepare 2 bottles of 100mL simulated body fluid with a sodium ion concentration of 140mM and a pH of 7.4, and add 1.5mM uric acid to one of the bottles as a crystallization solution;

[0062] (5) Set the temperature of the environment where the inorganic salt crystallization module III is located, use the constant temperature module I to maintain the temperature at 20°C, and monitor it in real time through the thermometer 8;

[0063] (6) Through the polyvinyl chloride transparent hose, the liquid outlet pipes of the crystallization liquid tank 6 and the...

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Abstract

The invention belongs to the technical field of crystallization, and particularly relates to a bionic system and method for in-vitro regulation and control of inorganic salt crystallization. The bionic system for in-vitro regulation and control of inorganic salt crystallization is mainly composed of a constant temperature module I, an ultraviolet sterilization module II, an inorganic salt crystallization module III and a real-time monitoring module IV. According to the invention, body fluid composition, human body temperature, pH, body fluid flow rate, inorganic salt crystallization microenvironment and concentration and the like are simulated, and simulation of the inorganic salt crystallization process in the physiological environment is realized. The crystal similar to the in-vivo inorganic salt in form can be obtained, and the crystallization mechanism of the in-vivo inorganic salt is disclosed. In addition, the crystal growth behavior can be regulated and controlled by functionalizing the flat sheet membrane. The crystallization system is low in cost, easy to build, easy to control, low in requirement for the surrounding environment, suitable for regulation and mechanism exploration of the inorganic salt crystallization process in different physiological environments, and important in research of pathological crystallization diseases.

Description

technical field [0001] The invention belongs to the technical field of crystallization, and in particular relates to a bionic system and method for regulating the crystallization of inorganic salts in vitro. Background technique [0002] Pathological crystallization is a common and frequently-occurring disease, mainly including urolithiasis, vascular calcification, kidney stones and crystal arthritis. relevant. In recent years, the incidence of such diseases has been rising around the world and tends to be younger, which seriously threatens human health and has become one of the research hotspots in the medical field. At present, the treatment of pathological crystalline diseases at home and abroad is mainly based on drugs and surgical removal, which will cause great damage to the human body. In fact, crystal lesions are all manifestations of crystallization caused by inorganic salts (such as calcium oxalate, calcium phosphate, and sodium urate, etc.) reaching supersaturat...

Claims

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Application Information

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IPC IPC(8): B01D9/00G01N25/14G01N21/84
CPCB01D9/0063G01N25/147G01N21/84G01N2021/8411G01N2021/8477
Inventor 姜晓滨孟英爽贺高红李中华肖武李祥村李甜甜吴雪梅
Owner DALIAN UNIV OF TECH
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