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Magnetic drive spiral micro-nano motor and preparation method and application thereof

A micro-nano and magnetic nano-technology, applied in the direction of pharmaceutical formula, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of poor application effect, poor stability of micro-nano motors, low production efficiency, etc. , to reduce the effect of cell activity, low cost and good biocompatibility

Active Publication Date: 2022-05-24
SHENZHEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of this application is to provide a magnetic-driven helical micro-nano motor and its preparation method, as well as the application of a magnetic-taxis micro-nano motor. Solve the problems of poor stability, low preparation efficiency and poor application effect in the field of biomedicine of existing micro-nano motors

Method used

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  • Magnetic drive spiral micro-nano motor and preparation method and application thereof
  • Magnetic drive spiral micro-nano motor and preparation method and application thereof
  • Magnetic drive spiral micro-nano motor and preparation method and application thereof

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preparation example Construction

[0032] A first aspect of the embodiments of the present application provides a method for preparing a magnetically driven helical micro-nano motor, comprising the following steps:

[0033] S10. Preparation of helical carbon nanocoils;

[0034] S20. After acidizing the helical carbon nano-coils, loading magnetic nanomaterials on the surface of the acidified helical carbon nano-coils to obtain CNCs / magnetic composite materials;

[0035] S30. Dissolve the anthracycline anticancer agent and the CNCs / magnetic composite material in a buffer solution, and perform a mixing process to bind the anthracycline anticancer agent on the surface of the helical carbon nanocoil to obtain a CNCs / magnetic material@anticancer agent Magnetically driven helical micro-nano motors.

[0036] The first aspect of the embodiments of the present application provides a method for preparing a magnetically driven helical micro-nanomotor, which prepares helical carbon nanocoil CNCs as a carrier for a magnetic...

Embodiment 1

[0068] A CNCs / Fe 3 O 4 @DOX magnetic drive helical micro-nano motor, the schematic diagram of its preparation process is attached figure 2 shown, including steps:

[0069] 1. Preparation of helical carbon nanocoil CNCs

[0070] ①Add 0.5mmol (202mg) of soluble Fe 3+ Salt (Fe(NO) 3 ) 3 ·9H 2 O, 202g / mol) dissolved in (30ml) N,N-dimethylformamide (DMF);

[0071] ②Add soluble Sn to the mixed solution 4+ Salt (SnCl 4 ·5H 2 O, 350.6g / mol), Fe 3+ with Sn 4+ The molar ratio was 10:1. After 30 minutes of ultrasonication, the mixture was transferred to a 100 ml Teflon container and transferred to an ultrasonic-microwave synergistic combination workbench. The ultrasonic frequency was 40KHz, the microwave power was 160W, and the conditions were 150°C. The reaction was carried out for two hours; after the reaction was completed, it was naturally cooled to room temperature; the resulting catalyst solution was subjected to vacuum filtration with a cellulose membrane with a pore ...

Embodiment 2

[0078] A CNCs / Fe 3 O 4 The difference between the preparation steps of @DOX magnetic drive helical micro-nano motor and Example 1 is:

[0079] 3. CNCs / Fe 3 O 4 Synthesis of @DOX Nanomotors

[0080] We removed 2 ml of phosphate-buffered saline (PBS) pH=8, 2 mmol of dopamine PDA; added 0.1 mg of CNCs / Fe 3 O 4 Micro-nano motor, after stirring overnight, add 0.1 mmol DOX doxorubicin, stir for 30 minutes, and refrigerate the mixed solution at 4°C for 2 days. Then, put the solution into a centrifuge tube and centrifuge at 6000r / min for 30 minutes to prepare CNCs / Fe 3 O 4@DOX micro-nano motors.

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Abstract

The invention belongs to the technical field of materials, and particularly relates to a magnetic drive spiral micro-nano motor and a preparation method and application thereof. The preparation method of the magnetic drive spiral micro-nano motor comprises the following steps: preparing a spiral carbon nano coil; the method comprises the following steps: acidizing a spiral carbon nano coil, and loading a magnetic nano material on the surface of the acidized spiral carbon nano coil to obtain a CNCs / magnetic composite material; and dissolving an anthracycline anti-cancer agent and the CNCs / magnetic composite material in a buffer solution, and carrying out mixing treatment to enable the anthracycline anti-cancer agent to be combined on the surface of the spiral carbon nano coil, so as to obtain the magnetically-driven spiral micro-nano motor of the CNCs / magnetic material anti-cancer agent. The preparation method is simple in process, high in efficiency and low in cost, the prepared magnetic drive spiral micro-nano motor is small in size, directional movement of a magnetic substance can be remotely controlled, the magnetic drive spiral micro-nano motor has good cell targeting capacity, target cells can be effectively killed, influences on activity of other cells are reduced, and biocompatibility is good.

Description

technical field [0001] The present application belongs to the technical field of materials, and in particular relates to a magnetic drive helical micro-nano motor and a preparation method thereof, and an application of a magnetotactic micro-nano motor. Background technique [0002] Micro / nanomotors are nanoscale devices that can convert other forms of energy into kinetic energy and move autonomously at the micro / nanoscale. Currently, there are few reported preparation methods for micro / nanomotors, and the fabrication of small-scale micro / nanomotors faces greater challenges. In addition, due to the influence of Brownian motion and fluid disturbance, the small size of the micro-nanomotor, the control of the motion direction of the small-sized nanomotor, biocompatibility, and good photothermal performance, etc. Important problems in the medical field greatly limit the application of nanomotors in the fields of biomedicine and micro-nano manipulation. [0003] Currently, many ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/52A61K47/69A61K41/00A61K31/704A61P35/00
CPCA61K47/52A61K47/6923A61K41/0052A61K31/704A61P35/00A61K2300/00
Inventor 孙燕明潘人杰孙磊汪国平
Owner SHENZHEN UNIV
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