Kit for detecting or assisting in detecting tumor-related gene variation and application thereof

A tumor-related gene and auxiliary detection technology, applied in the field of biomedicine, can solve the problems of low detection sensitivity, missed detection of low-frequency mutations, limited application scope, etc., and achieve the effect of strong exploration ability, high sensitivity and low detection limit.
CN114525344AInactive Publication Date: 2022-05-24普瑞基准科技(北京)有限公司 +2
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
普瑞基准科技(北京)有限公司
Publication Date
2022-05-24
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a kit for detection or auxiliary detection of tumor-related gene variation and application thereof, the kit comprises a set of DNA probes, and the set of DNA probes comprises DNA probes as shown in SEQ ID NO: 1-SEQ ID NO: 320. The invention relates to a kit (Panel product) capable of detecting 80 genes, which can be used for detecting a solid tumor targeted drug or a biomarker corresponding to an immune checkpoint inhibitor approved by the American Food and Drug Administration (FDA) / State Drug Administration (NMPA) at present at one time. A tumor tissue sample and a whole blood sample of a subject are collected, and tumor content evaluation, DNA extraction, library establishment, capture, sequencing, bioinformatics analysis and medical interpretation are carried out, so that a biomarker for guiding precise treatment is found.
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Description

technical field

[0001] The invention relates to the field of biomedicine, in particular to a kit for detecting or assisting the detection of tumor-related gene variation and its application. Background technique

[0002] According to statistics from the National Cancer Center, in 2015, the number of new cancer cases in my country was 1.8639 / 100,000, and the mortality rate was 105.84 / 100,000, which seriously threatens human health. Clinical studies classify tumors as a genetic disease, mainly caused by the activation of proto-oncogenes or the inactivation of inhibitory genes. With the great progress of high-throughput sequencing (NGS) and biotechnology, many driver genes related to the occurrence and development of cancer and biomarkers that can be used to guide tumor treatment have been discovered, and many driver genes and biomarkers have been developed. This type of drug can be used for precise treatment based on detected driver gene mutations or biomarkers in clinical tr...

Claims

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