Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

Metal organic framework material for tumor microwave thermal-dynamic therapy as well as preparation method and application of metal organic framework material

A metal-organic framework and microwave technology, applied in photodynamic therapy, wave energy or particle radiation treatment materials, anti-tumor drugs, etc. Kill tumors and other problems, achieve good tumor treatment effect, good clinical application value, and uniform size effect

Pending Publication Date: 2022-05-27
TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
View PDF7 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the temperature will drop rapidly at the edge of the tumor far away from the microwave source, resulting in insufficient heat, so it is difficult to completely kill tumor cells
And these tumor cells in a sublethal state may be revived through self-repair, resulting in local lesions remaining in the tumor area after microwave hyperthermia, resulting in local recurrence of the tumor
Therefore, a single microwave-sensitized hyperthermia still cannot meet the needs of the complex and changeable microenvironment of the tumor, and cannot completely kill the tumor.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Metal organic framework material for tumor microwave thermal-dynamic therapy as well as preparation method and application of metal organic framework material
  • Metal organic framework material for tumor microwave thermal-dynamic therapy as well as preparation method and application of metal organic framework material
  • Metal organic framework material for tumor microwave thermal-dynamic therapy as well as preparation method and application of metal organic framework material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] 100 mg of Ni (NO 3 ) 2 ·6H 2 O and 100 mg of Co(NO 3 ) 2 ·6H 2 O was placed in a glass bottle and dispersed with 5 mL of methanol ultrasonically; 400 mg of 2-methylimidazole was placed in a glass bottle, and 5 mL of methanol was also used for ultrasonic dispersion, added to the above solution and mixed, and magnetically stirred at room temperature for 6 hours; then the obtained The product was centrifuged in a centrifuge tube, washed twice with ethanol, and finally the sample was freeze-dried to obtain a powdered product.

[0049] For the transmission electron microscope photo, scanning electron microscope photo, size distribution under the scanning electron microscope photo, and hydrated particle size distribution of the metal-organic framework material prepared in Example 1, please refer to Figure 1-4 . It can be seen from the figure that the diameter of the metal-organic framework material prepared in this example is 40-500nm, preferably in the range of 40-100...

Embodiment 2

[0051] 100 mg of NiCl 2 ·6H 2 O and 100mg CoCl 2 ·6H 2 O was placed in a glass bottle and dispersed with 5 mL of methanol ultrasonically; 400 mg of 2-methylimidazole was placed in a glass bottle, and 5 mL of methanol was also used for ultrasonic dispersion, added to the above solution and mixed, and magnetically stirred at room temperature for 6 hours; then the obtained The product was centrifuged in a centrifuge tube, washed twice with ethanol, and finally the sample was freeze-dried to obtain a powdered product.

[0052] The transmission electron microscope photo of the metal-organic framework material prepared in Example 2 is shown in Figure 8 . It can be seen from the figure that the diameter of the metal-organic framework material prepared in this example is 40-500nm, preferably in the range of 40-100nm particle size, has high specific surface area and porous structure, and has uniform size and monodispersity. it is good.

Embodiment 3

[0054] 100 mg of Ni(CH 3 COO) 2 and 100mg Co(CH 3 COO) 2 Put it in a glass bottle, and ultrasonically disperse it with 5 mL of methanol; put 400 mg of 2-methylimidazole in a glass bottle, also use 5 mL of methanol to ultrasonically disperse it, add it to the above solution and mix well, and stir magnetically for 6 hours at room temperature; then the obtained The product was centrifuged in a centrifuge tube, washed twice with ethanol, and finally the sample was lyophilized to obtain a powdered product.

[0055] The transmission electron microscope photo of the metal-organic framework material prepared in Example 3 is shown in Figure 11 . It can be seen from the figure that the diameter of the metal-organic framework material prepared in this example is 40-500nm, preferably in the range of 40-100nm particle size, has high specific surface area and porous structure, and has uniform size and monodispersity. it is good.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
Diameteraaaaaaaaaa
Login to View More

Abstract

The invention discloses a metal organic framework material for tumor microwave thermal-dynamic therapy as well as a preparation method and application of the metal organic framework material. Central metal ions of the metal organic framework material are nickel ions and cobalt ions. The metal organic framework material can be used for tumor microwave hyperthermia sensitization and microwave power therapy, and a good tumor treatment effect can be achieved.

Description

technical field [0001] The invention relates to the preparation technology of metal-organic framework materials and the field of biological application thereof, in particular to a metal-organic framework material for tumor microwave thermo-dynamic therapy, a preparation method and application thereof. Background technique [0002] Cancer (malignant tumor) has increasingly become one of the major public health problems that seriously threaten human health (CACancer J Clin 2018, 68, 394-424). The latest statistics from the National Cancer Center show that in the past 10 years, the cancer incidence rate has maintained an annual increase of about 3.9%, and the mortality rate has maintained an annual increase of about 2.5% (Chin J Cancer Res 2018, 30(1), 1-12, Chin J Cancer Res 2018, 30(1), 1-12, Chin J Cancer Res 2019, 31(1), 99-116). Residents' deaths caused by cancer account for about 23.91% of all deaths, and in the past ten years, the incidence and deaths of cancer have con...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C08G83/00A61K41/00A61P35/00
CPCC08G83/008A61K41/0052A61K41/0057A61P35/00
Inventor 吴琼孟宪伟谭龙飞任湘菱付长慧
Owner TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com