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Composition for ophthalmology as well as preparation method and application of composition

A composition and ophthalmology technology, applied in the field of medicine, can solve the problems of no antioxidant substances, lack of eye skin and lens damage, etc., achieve low cytotoxicity, improve moisturizing effect, and relieve dry eyes

Pending Publication Date: 2022-06-07
深圳中科欣扬生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Aiming at the existing problems such as adding preservatives to easily produce side effects, no antioxidant substances, lack of scavenging of various free radicals produced by body metabolism and protection of eye skin and lens damage caused by oxidation, the present invention provides an ophthalmic composition

Method used

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  • Composition for ophthalmology as well as preparation method and application of composition
  • Composition for ophthalmology as well as preparation method and application of composition
  • Composition for ophthalmology as well as preparation method and application of composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-5

[0062] Pharmacodynamic experiments of the ophthalmic compositions of Examples 1-5, Comparative Examples 1-4 and the matrix group

[0063] 1. Cytotoxicity test

[0064] Set the concentration to 1 x 10 5 Cells / mL of the corneal stromal cell suspension was added to a 96-well plate at 100 μl / well in 5% CO containing 2 , culture in a 37°C incubator for 24 hours, and aspirate the medium. Then, the above-mentioned ophthalmic composition and serum-free medium were added to a 96-well plate at a ratio of 1:10 (volume ratio), and cultured for 24 hours in an environment containing 5±1% carbon dioxide and a temperature of 37±1°C. Six replicates were set for positive (10% DMSO), negative (complete cell culture) control and ophthalmic composition dilutions. The 96-well plate was removed and 20ul of MTT solution was added to each well. Incubate in an incubator for 3h. After incubation, add 100 μl DMSO, shake for 10 min, measure the absorbance on a microplate reader at a wavelength of 570...

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PUM

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Abstract

The invention discloses an ophthalmic composition containing ectoine, SOD (superoxide dismutase) and ergothioneine as well as a preparation method and application of the ophthalmic composition. The composition for ophthalmology comprises the following components in percentage by mass volume: 0.1%-5% (w / v) of ectoine or a derivative thereof, 0.01%-0.2% of ergothioneine (w / v) and 0.1%-2% of SOD (w / v). The ophthalmic composition of the present invention can be used as a contact lens eye moisturizer. The ophthalmic composition prepared by the invention has the effects of effectively relieving eye dryness and fatigue when a user wears contact lenses, protecting ocular surface cells, resisting free radicals, preventing cataract, improving eyesight and the like.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to an ophthalmic composition containing tetrahydropyrimidine, SOD and ergothioneine without bactericidal preservatives, which can be used to lubricate dry or uncomfortable eyes when wearing contact lenses. Background technique [0002] According to the World Health Organization (WHO) report, 20% of children worldwide need to wear glasses. There are currently three clinically recognized and effective ways of correcting myopia: spectacles, contact lenses, and surgical correction. Contact lenses are also called contact lenses. Compared with frame glasses, they are more beautiful and convenient, and have a wide field of view and realistic vision. Therefore, contact lenses are favored and widely used by patients with myopia. However, contact lenses generally have poor oxygen permeability. Wearing contact lenses for a long time will cause corneal hypoxia, which will lead to the disord...

Claims

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Application Information

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IPC IPC(8): A61K8/66A61K8/49A61Q19/00A61P27/02A61P29/00
CPCA61K8/66A61K8/4946A61K8/4953A61Q19/00A61P27/02A61P29/00A61K2800/592A61K2800/522
Inventor 张山丁利平顾丽红董亮
Owner 深圳中科欣扬生物科技有限公司
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