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Uridine derivative-containing nanoparticle, nucleic acid nanocomposite, and preparation method and application thereof

A nucleic acid nano and nano particle technology, applied in the field of biomedicine, can solve the problems of poor bioavailability, non-degradable, poor transfection effect, etc.

Active Publication Date: 2022-06-07
SHENZHEN LONGUIDE BIOPHARMA CORP
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Compared with viral vectors, liposome nanoparticles have the advantages of low production cost, clear chemical structure, convenient quality control, targeted drug delivery through targeted modification, and unlimited loading capacity in theory. Plastid lipid materials are non-degradable and highly toxic, so it is difficult to meet the clinical needs of repeated administration. In addition, there are problems such as poor transfection effect in vivo, nucleic acid is metabolized or cleared in serum, and poor bioavailability.

Method used

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  • Uridine derivative-containing nanoparticle, nucleic acid nanocomposite, and preparation method and application thereof
  • Uridine derivative-containing nanoparticle, nucleic acid nanocomposite, and preparation method and application thereof
  • Uridine derivative-containing nanoparticle, nucleic acid nanocomposite, and preparation method and application thereof

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Embodiment Construction

[0017] To solve the above problems, the present invention provides the following technical solutions.

[0018] In a first aspect, there is provided a compound of formula I or a stereoisomer or tautomer thereof.

[0019] a compound of formula I or a stereoisomer or tautomer thereof,

[0020] ,

[0021] where n is 0, 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10.

[0022] In some embodiments, the compound of formula I comprises a compound selected from the group consisting of: a compound of formula A, a compound of formula B, or a compound of formula C,

[0023] , or

[0024] , where n is 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10.

[0025] In the context of this invention, the NBD004 compound refers to the compound of formula C.

[0026] In a second aspect, a method for preparing a compound of formula I, a compound of formula A, a compound of formula B or a compound of formula C is provided.

[0027] A preparation method of a compound of formula I, comprising:

[0028] ,

[0029] ...

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Abstract

The invention relates to a uridine derivative-containing nanoparticle, a nucleic acid nanocomposite and a preparation method and application thereof, and belongs to the field of biological medicines. The nanoparticle comprises a compound as shown in a formula I and an auxiliary material. The nanoparticles can entrap nucleic acid, and have the advantages of low toxicity, high entrapment efficiency, good transfection effect and good bioavailability. The preparation method is simple to operate, low in cost, environment-friendly and beneficial to industrial production.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a uridine derivative-containing nanoparticle, a nucleic acid nanocomposite and a preparation method and application thereof. Background technique [0002] Gene transfection is a technique of transferring or transporting nucleic acid with biological function into cells and maintaining the biological function of nucleic acid in cells. Gene carrier refers to a tool for introducing exogenous therapeutic genes into biological cells. At present, the gene vectors with industrial transformation potential in the world are mainly viral vectors and non-viral vectors. [0003] Viral vectors are a gene delivery tool that utilizes the ability of viruses to transmit their genomes into other cells for infection. Currently, lentiviruses, adenoviruses, retrovirus vectors and adeno-associated virus vectors have good application prospects. However, viral vectors have serious disadvantages due to their i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H19/067C07H19/06C07H1/00A61K31/7088A61P31/04A61P31/12A61P9/00A61P17/00A61K39/00A61K9/14A61P35/00
CPCC07H19/067C07H19/06C07H1/00A61K31/7088A61P31/04A61P31/12A61P9/00A61P17/00A61K39/00A61K9/146A61P35/00
Inventor 张龙贵刘晨梁梅桂王宇恒
Owner SHENZHEN LONGUIDE BIOPHARMA CORP
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