Method for synthesizing levodopa by taking L-tyrosine as substrate
A synthesis method and tyrosine technology, which are applied in the field of levodopa synthesis, can solve the problems of low conversion rate and high separation cost, and achieve the effects of improving conversion rate, raw material cost and product purification cost.
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Embodiment 1
[0022] An electrode system was constructed in an electrochemical reactor (30 mL), including a working electrode, a reference electrode and a counter electrode, the working electrode was a thin-film modified glassy carbon electrode; the reference electrode was silver chloride; the counter electrode is a platinum counter electrode;
[0023] A 7 mg / mL tyrosinase solution was prepared in 0.15 mol / L phosphate buffer (pH 6.5). 7 mg of chitosan was dissolved in 3 mL of 0.2 mol / L acetic acid to prepare a chitosan solution with a concentration of 4 mg / mL. The nickel nanoparticles (particle size: 150 nm) were dispersed in double distilled water for 4 h with ultrasonic waves to obtain a nickel nanoparticle suspension of 2-3 mg / mL. The nickel nanoparticles, chitosan and tyrosinase were thoroughly mixed in a volume ratio of 1:2:3 to obtain a mixed solution, and the mixed solution was adsorbed on the carbon felt, dried for 5 hours, and coated with Nafion solution on the carbon felt , In N...
Embodiment 2
[0027] An electrode system was constructed in an electrochemical reactor (30 mL), including a working electrode, a reference electrode and a counter electrode, the working electrode was a thin-film modified glassy carbon electrode; the reference electrode was silver chloride; the counter electrode is a platinum counter electrode;
[0028] A 6 mg / mL tyrosinase solution was prepared in 0.15 mol / L phosphate buffer (pH 6.5). 6 mg of chitosan was dissolved in 2.5 mL of 0.15 mol / L acetic acid to prepare a chitosan solution with a concentration of 3 mg / mL. The nickel nanoparticles (particle size: 100 nm) were dispersed in double-distilled water for 3 h with ultrasonic waves to obtain a nickel nanoparticle suspension of 2-3 mg / mL. The nickel nanoparticles, chitosan and tyrosinase were thoroughly mixed in a volume ratio of 1:2:2 to obtain a mixed solution, and the mixed solution was adsorbed on the carbon felt, dried for 4 hours, and coated with Nafion solution on the carbon felt , I...
Embodiment 3
[0032] An electrode system was constructed in an electrochemical reactor (30 mL), including a working electrode, a reference electrode and a counter electrode, the working electrode was a thin-film modified glassy carbon electrode; the reference electrode was silver chloride; the counter electrode is a platinum counter electrode;
[0033] A tyrosinase solution at a concentration of 8 mg / mL was prepared in 0.2 mol / L phosphate buffer (pH 6.5). 8 mg of chitosan was dissolved in 4 mL of 3 mol / L acetic acid to prepare a chitosan solution with a concentration of 5 mg / mL. The nickel nanoparticles (particle size: 200 nm) were dispersed in double-distilled water for 5 h with ultrasonic waves to obtain a nickel nanoparticle suspension of 2-3 mg / mL. The nickel nanoparticles, chitosan and tyrosinase were thoroughly mixed in a volume ratio of 1:3:4 to obtain a mixed solution, and the mixed solution was adsorbed on the carbon felt, dried for 6 hours, and coated with Nafion solution on the ...
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