Modified microorganism, modification method and application thereof, and antitumor drug

Abstract

The invention discloses a modified microorganism, a modification preparation method and application thereof, and an anti-tumor drug, the microorganism in the modified microorganism is specifically modified by a metal organic framework material, and the microorganism is an anaerobic or facultative anaerobic microorganism with anti-tumor activity; the modified microorganism can be used for tumor treatment, can be enriched in tumors, can realize combination of photodynamic therapy and immunotherapy, and is good in tumor treatment effect, low in toxicity and high in safety.

Description

technical field [0001] The invention relates to the technical field of biomedicine, in particular to a modified microorganism, a modification method and application thereof, and an antitumor drug. Background technique [0002] Cancer is a serious threat to human life and health, and there is still no effective treatment method. Colorectal cancer (CRC) is the third most common cancer in the world, with a mortality rate of about 10%. The incidence of CRC is very high in developed countries, especially in Europe, North America, Australia and New Zealand. The progression of this cancer is closely related to dietary habits, living conditions and environmental factors. Although early diagnosis and early treatment reduce the possibility of tumor progression and recurrence, the efficacy of conventional antitumor methods such as chemotherapy, radiotherapy and surgery remains unsatisfactory, especially for malignant metastatic cancers. In order to effectively and long-term eliminat...

AI Technical Summary

Problems solved by technology

However, there are still many drawbacks in drug delivery, such as reduced tumor targeting, low accumulation in the tumor microenvironment (TME), and poor drug release, which hinder the widespread application of traditional nanomaterials in the clinic.

Metal-organic frameworks (MOFs) are porous nanostructures. Existing studies have used MOFs directly for tumor therapy, but they cannot actively target the hypoxic environment of tumors, and there is a problem of poor curative effect.

[0004] Although pathogenic bacteria are harmful to human health, some non-pathogenic strains have unique advantages in cancer treatment and are used in tumor therapy. For example, existing studies can use lactic acid bacteria and E. The effect is not obvious, the tumor disappears slowly and easily recurs

Images