Non-steroidal anti-inflammatory drug DCF detection membrane material as well as preparation method and application thereof

A technology for non-steroidal anti-inflammatory drugs and membrane materials, applied in the field of analytical chemistry, can solve problems such as limitations, and achieve the effects of simple operation, good visibility, excellent recyclability and reproducibility

Pending Publication Date: 2022-06-24
ANHUI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, traditional sensing platforms usually focus on crystalline powders or b

Method used

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  • Non-steroidal anti-inflammatory drug DCF detection membrane material as well as preparation method and application thereof
  • Non-steroidal anti-inflammatory drug DCF detection membrane material as well as preparation method and application thereof
  • Non-steroidal anti-inflammatory drug DCF detection membrane material as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0025] Example 1 Preparation of MMMs

[0026] First, prepare 1,3,5-benzenetricarboxylic acid (BTC) as 0.3M ethanol solution, prepare Tb(NO 3 ) 3 ·6H 2 O is 0.3M ethanol solution, then mixed well, ultrasonicated for 30-60 minutes, and finally centrifuged and washed to obtain Tb-MIL-78.

[0027] Polyacrylonitrile (1.5 g) was weighed into DMF (15 ml), stirred and dissolved at room temperature for 12 hours to obtain a solution before spinning.

[0028] Tb-MIL-78 (0.3 g) was added to the pre-spinning solution and stirred until Tb-MIL-78 was uniformly dispersed in the solution. The prepared solution was used for electrospinning (the moving speed of the solvent box was 100 mm / s, and the voltage was 40 KV) to obtain MMMs with a size of about 0.5 m × 0.5 m. figure 1 Fluorescence spectra of MMMs.

Example Embodiment

[0029] Example 2 Preparation of MMMs

[0030] First, prepare 1,3,5-benzenetricarboxylic acid (BTC) as 0.3M ethanol solution, prepare Eu(NO 3 ) 3 ·6H 2 O is 0.3M ethanol solution, then mixed well, ultrasonicated for 30-60 minutes, and finally centrifuged and washed to obtain Eu-MIL-78.

[0031] Polyacrylonitrile (1.5 g) was weighed into DMF (15 ml), stirred and dissolved at room temperature for 12 hours to obtain a solution before spinning.

[0032] Eu-MIL-78 (0.3 g) was added to the pre-spinning solution and stirred until Eu-MIL-78 was uniformly dispersed in the solution. The prepared solution was used for electrospinning (the moving speed of the solvent box was 100 mm / s, and the voltage was 40 KV) to obtain MMMs with a size of about 0.5 m × 0.5 m.

Example Embodiment

[0033] Example 3 Preparation of MMMs

[0034] First, prepare 1,3,5-benzenetricarboxylic acid (BTC) as 0.2M ethanol solution, prepare Tb(NO 3 ) 3 ·6H 2 O is 0.2M ethanol solution, then mixed well, ultrasonicated for 30-60 minutes, and finally centrifuged and washed to obtain Tb-MIL-78.

[0035] Polyacrylonitrile (1.5 g) was weighed into DMF (10 ml), stirred and dissolved at room temperature for 12 hours to obtain a solution before spinning.

[0036] Tb-MIL-78 (0.2 g) was added to the pre-spinning solution and stirred until Tb-MIL-78 was uniformly dispersed in the solution. The prepared solution was used for electrospinning (the moving speed of the solvent box was 200 mm / s, and the voltage was 30 KV) to obtain MMMs with a size of about 0.5 m × 0.5 m.

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Abstract

The invention discloses a non-steroidal anti-inflammatory drug DCF detection membrane material and a preparation method and application thereof, and the preparation method comprises the following steps: preparing 0.2 M-0. 3 M of 1, 3, 5-benzene tricarboxylic acid (BTC) ethanol solution and 0.2 M-0. 3 M of Ln (NO3) 3.6 H2O ethanol solution, then uniformly mixing, finally carrying out ultrasonic treatment for 30-60 minutes, centrifuging, and washing to obtain Ln-MIL-78; polyacrylonitrile is used for preparing a pre-spinning solution with the mass fraction of 8%-12%; adding Ln-MIL-78 into the solution before spinning, and stirring until the Ln-MIL-78 is uniformly dispersed in the solution to obtain a spinning solution; the prepared spinning solution is used for electrostatic spinning, and the non-steroidal anti-inflammatory drug DCF detection membrane material MMMs is obtained; no matter in the presence of a large number of interfering substances or in a complex biological endogenous environment, a sensing platform can still perform specific response on the DCF with excellent accuracy. The light-emitting sensing platform not only has the advantages of simplicity in operation, good visibility and the like, but also can keep good response to an analyte after 20 cycles, and shows excellent recoverability and reproducibility.

Description

technical field [0001] The invention belongs to the field of analytical chemistry, in particular to a non-steroidal anti-inflammatory drug DCF detection membrane material and a preparation method and application thereof. ) and developed it as a sensing platform for the rapid detection of diclofenac (DCF) in serum. Background technique [0002] Diclofenac (DCF) is a synthetic non-steroidal anti-inflammatory drug (NSAID) with analgesic, anti-inflammatory and antipyretic effects in humans. It is mainly eliminated by liver metabolism, so it has obvious side effects on the liver. Long-term or large doses of DCF can cause severe liver and kidney damage, even life-threatening. Therefore, it is very important to determine the concentration of DCF in serum. Currently, DCF detection methods include high performance thin layer chromatography (HPTLC), high pressure liquid chromatography (HPLC), electrophoretic analysis and fluorescence sensing. Among these methods, luminescence anal...

Claims

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Application Information

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IPC IPC(8): G01N21/64
CPCG01N21/6428G01N2021/6432G01N2021/6417
Inventor 牛和林程乐乐廉笑朱良武
Owner ANHUI UNIVERSITY
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